Lyra Therapeutics, Inc. (LYRA)
Valuation Overview•Is Lyra Therapeutics, Inc. Overvalued or Undervalued?
Popular:
Weak fundamentals — significant concerns
Total return, benchmark alpha, and annual history in one section.
3Y, 5Y, and 10Y use CAGR when available.
| Period | Return | vs S&P | Dividends |
|---|---|---|---|
| YTD | -86.1% | -93.2% | — |
| 1Y | -91.6% | -122.0% | — |
| 3YCAGR | -85.0% | -106.0% | — |
| 5YCAGR | -74.6% | -86.3% | — |
| 10YCAGR | -53.5% | -67.0% | — |
Year-by-year total return versus SPY, including dividend contribution.
| Year | Stock Return | SPY Return | Alpha | Dividends |
|---|---|---|---|---|
| 2026YTD | -68.0% | +0.4% | -68.5% | — |
| 2025 | -71.5% | +16.6% | -88.1% | — |
| 2024Worst | -96.0% | +24.0% | -120.0% | — |
| 2023Best | +69.6% | +24.8% | +44.8% | — |
| 2022 | -32.9% | -19.9% | -13.0% | — |
| 2021 | -61.2% | +28.8% | -90.0% | — |
| 2020 | -38.6% | +15.1% | -53.7% | — |
Based on our multi-model analysis of Lyra Therapeutics, Inc. (LYRA) at $0.44: Fundamental quality score: 33/100 (below average). This is a quantitative summary combining DCF intrinsic value, peer-based relative valuation, quality scoring, and analyst consensus — not a buy/sell recommendation. Always consult a qualified financial advisor before investing.
Fair value data is not yet available for LYRA.
Lyra Therapeutics, Inc.'s financial health as measured by our composite scoring: Overall quality score: 33/100. Piotroski F-Score: 2/9 (weak fundamentals). Altman Z-Score: -13.5 (distress zone — elevated risk). Return on invested capital: -145.5%. Cash conversion (OCF/NI): 0.75x (earnings exceed cash generation). The quality score blends profitability (ROIC, ROE, margins), solvency (leverage, coverage, Z-Score), and growth trajectory into a single 0–100 framework updated end-of-day.
Lyra Therapeutics, Inc.'s performance profile: 1-year total return: -91.6%. 1-year alpha vs S&P 500: -122.0% (underperforming the benchmark). 5-year CAGR: -74.6%. Maximum drawdown (1Y): -98.4%. Relative Strength rating: 1/99 (weak momentum). Beta: 0.65 (less volatile than the market). Total returns include reinvested dividends. Alpha is calculated against the S&P 500 Total Return Index over matching periods.
Lyra Therapeutics, Inc. does not currently pay a dividend or conduct significant share buybacks. The company is retaining capital for reinvestment.
No analyst coverage data available for LYRA.
Key risks identified for Lyra Therapeutics, Inc.: Drawdown risk: The stock experienced a -98.4% max drawdown in the past year. Solvency risk: Altman Z-Score (-13.5) is in the distress zone, indicating elevated bankruptcy risk. Note: This model does not capture regulatory changes, management decisions, competitive disruption, or geopolitical events. Macro and qualitative risks remain material and should be assessed independently.
No. This overview dashboard aggregates data from our DCF intrinsic value model, relative peer multiples model, proprietary estimates engine, and third-party analyst consensus feeds. It is strictly for educational and informational purposes. The operator of this platform is not a registered investment advisor (RIA), broker-dealer, or financial planner. All model outputs, fair value estimates, quality scores, and signals are automated quantitative computations and should not be construed as investment recommendations. Consult a qualified, licensed financial advisor before making any investment decisions. Past model performance does not guarantee future results.