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DYAI vs CDXS vs GEVO vs BEAM vs TWST

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
DYAI
Dyadic International, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$27M
5Y Perf.-87.8%
CDXS
Codexis, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$234M
5Y Perf.-79.2%
GEVO
Gevo, Inc.

Chemicals - Specialty

Basic MaterialsNASDAQ • US
Market Cap$493M
5Y Perf.+57.4%
BEAM
Beam Therapeutics Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$3.23B
5Y Perf.+23.2%
TWST
Twist Bioscience Corporation

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$3.65B
5Y Perf.+54.3%

DYAI vs CDXS vs GEVO vs BEAM vs TWST — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
DYAI logoDYAI
CDXS logoCDXS
GEVO logoGEVO
BEAM logoBEAM
TWST logoTWST
IndustryBiotechnologyBiotechnologyChemicals - SpecialtyBiotechnologyMedical - Diagnostics & Research
Market Cap$27M$234M$493M$3.23B$3.65B
Revenue (TTM)$3M$70M$174M$132M$409M
Net Income (TTM)$-7M$-44M$-11M$-65M$-81M
Gross Margin42.2%79.5%23.4%-64.2%52.1%
Operating Margin-273.4%-54.5%-4.6%-281.0%-33.9%
Total Debt$5M$73M$168M$294M$137M
Cash & Equiv.$7M$51M$1M$295M$183M

DYAI vs CDXS vs GEVO vs BEAM vs TWSTLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

DYAI
CDXS
GEVO
BEAM
TWST
StockMay 20May 26Return
Dyadic Internationa… (DYAI)10012.2-87.8%
Codexis, Inc. (CDXS)10020.8-79.2%
Gevo, Inc. (GEVO)100157.4+57.4%
Beam Therapeutics I… (BEAM)100123.2+23.2%
Twist Bioscience Co… (TWST)100154.3+54.3%

Price return only. Dividends and distributions are not included.

Quick Verdict: DYAI vs CDXS vs GEVO vs BEAM vs TWST

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: GEVO leads in 3 of 6 categories (5-stock set), making it the strongest pick for growth and revenue expansion and profitability and margin quality. Dyadic International, Inc. is the stronger pick specifically for capital preservation and lower volatility. BEAM also leads in specific categories worth noting. This set spans 2 sectors — these stocks serve different portfolio roles, not just different price points.
DYAI
Dyadic International, Inc.
The Income Pick

DYAI is the #2 pick in this set and the best alternative if income & stability and defensive is your priority.

  • beta 0.98
  • Beta 0.98, current ratio 4.01x
  • Beta 0.98 vs TWST's 2.47
Best for: income & stability and defensive
CDXS
Codexis, Inc.
The Healthcare Pick

CDXS lags the leaders in this set but could rank higher in a more targeted comparison.

Best for: healthcare exposure
GEVO
Gevo, Inc.
The Growth Play

GEVO carries the broadest edge in this set and is the clearest fit for growth exposure.

  • Rev growth 8.5%, EPS growth 58.8%, 3Y rev CAGR 415.1%
  • 8.5% revenue growth vs CDXS's 18.6%
  • -6.6% margin vs DYAI's -279.6%
  • -1.7% ROA vs DYAI's -63.0%, ROIC -2.8% vs -16.7%
Best for: growth exposure
BEAM
Beam Therapeutics Inc.
The Defensive Pick

BEAM ranks third and is worth considering specifically for sleep-well-at-night.

  • Lower volatility, beta 2.14, Low D/E 23.7%, current ratio 13.09x
  • +93.9% vs DYAI's -31.7%
Best for: sleep-well-at-night
TWST
Twist Bioscience Corporation
The Long-Run Compounder

TWST is the clearest fit if your priority is long-term compounding.

  • 318.1% 10Y total return vs BEAM's 67.8%
Best for: long-term compounding
See the full category breakdown
CategoryWinnerWhy
GrowthGEVO logoGEVO8.5% revenue growth vs CDXS's 18.6%
Quality / MarginsGEVO logoGEVO-6.6% margin vs DYAI's -279.6%
Stability / SafetyDYAI logoDYAIBeta 0.98 vs TWST's 2.47
DividendsTieNone of these 5 stocks pay a meaningful dividend
Momentum (1Y)BEAM logoBEAM+93.9% vs DYAI's -31.7%
Efficiency (ROA)GEVO logoGEVO-1.7% ROA vs DYAI's -63.0%, ROIC -2.8% vs -16.7%

DYAI vs CDXS vs GEVO vs BEAM vs TWST — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

DYAIDyadic International, Inc.
FY 2024
License
54.1%$2M
Research and Development
45.9%$2M
CDXSCodexis, Inc.
FY 2025
Research And Development Revenue
63.0%$44M
Product
37.0%$26M
GEVOGevo, Inc.
FY 2025
Ethanol
95.6%$105M
Hydrocarbon
4.4%$5M
BEAMBeam Therapeutics Inc.

Segment breakdown not available.

TWSTTwist Bioscience Corporation
FY 2025
Ngs Tools
55.3%$208M
Synthetic Genes
30.2%$114M
Antibody Discovery
6.2%$23M
Oligo Pools
5.4%$20M
Dna And Biopharma Libraries
3.0%$11M

DYAI vs CDXS vs GEVO vs BEAM vs TWST — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLGEVOLAGGINGBEAM

Income & Cash Flow (Last 12 Months)

Evenly matched — CDXS and GEVO each lead in 3 of 6 comparable metrics.

TWST is the larger business by revenue, generating $409M annually — 155.8x DYAI's $3M. Profitability is closely matched — net margins range from -6.6% (GEVO) to -2.8% (DYAI). On growth, CDXS holds the edge at +81.3% YoY revenue growth, suggesting stronger near-term business momentum.

MetricDYAI logoDYAIDyadic Internatio…CDXS logoCDXSCodexis, Inc.GEVO logoGEVOGevo, Inc.BEAM logoBEAMBeam Therapeutics…TWST logoTWSTTwist Bioscience …
RevenueTrailing 12 months$3M$70M$174M$132M$409M
EBITDAEarnings before interest/tax-$7M-$30M$18M-$355M-$115M
Net IncomeAfter-tax profit-$7M-$44M-$11M-$65M-$81M
Free Cash FlowCash after capex-$5M-$24M-$35M-$384M-$95M
Gross MarginGross profit ÷ Revenue+42.2%+79.5%+23.4%-64.2%+52.1%
Operating MarginEBIT ÷ Revenue-2.7%-54.5%-4.6%-2.8%-33.9%
Net MarginNet income ÷ Revenue-2.8%-62.5%-6.6%-49.2%-19.8%
FCF MarginFCF ÷ Revenue-176.1%-33.9%-19.9%-2.9%-23.2%
Rev. Growth (YoY)Latest quarter vs prior year-40.5%+81.3%+47.5%-100.0%+19.3%
EPS Growth (YoY)Latest quarter vs prior year+184.6%+3.8%+26.6%-7.6%
Evenly matched — CDXS and GEVO each lead in 3 of 6 comparable metrics.

Valuation Metrics

GEVO leads this category, winning 2 of 3 comparable metrics.
MetricDYAI logoDYAIDyadic Internatio…CDXS logoCDXSCodexis, Inc.GEVO logoGEVOGevo, Inc.BEAM logoBEAMBeam Therapeutics…TWST logoTWSTTwist Bioscience …
Market CapShares × price$27M$234M$493M$3.2B$3.6B
Enterprise ValueMkt cap + debt − cash$26M$257M$659M$3.2B$3.6B
Trailing P/EPrice ÷ TTM EPS-3.73x-5.16x-14.50x-38.85x-45.03x
Forward P/EPrice ÷ next-FY EPS est.
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple102.12x
Price / SalesMarket cap ÷ Revenue7.71x3.33x3.07x23.14x9.68x
Price / BookPrice ÷ Book value/share8.84x4.45x1.01x2.51x7.40x
Price / FCFMarket cap ÷ FCF
GEVO leads this category, winning 2 of 3 comparable metrics.

Profitability & Efficiency

GEVO leads this category, winning 5 of 9 comparable metrics.

GEVO delivers a -2.4% return on equity — every $100 of shareholder capital generates $-2 in annual profit, vs $-3 for DYAI. BEAM carries lower financial leverage with a 0.24x debt-to-equity ratio, signaling a more conservative balance sheet compared to DYAI's 2.05x. On the Piotroski fundamental quality scale (0–9), CDXS scores 4/9 vs DYAI's 3/9, reflecting mixed financial health.

MetricDYAI logoDYAIDyadic Internatio…CDXS logoCDXSCodexis, Inc.GEVO logoGEVOGevo, Inc.BEAM logoBEAMBeam Therapeutics…TWST logoTWSTTwist Bioscience …
ROE (TTM)Return on equity-2.8%-90.5%-2.4%-5.9%-17.5%
ROA (TTM)Return on assets-63.0%-32.6%-1.7%-4.6%-12.5%
ROICReturn on invested capital-16.7%-31.9%-2.8%-31.1%-26.9%
ROCEReturn on capital employed-87.7%-30.9%-3.1%-33.3%-24.9%
Piotroski ScoreFundamental quality 0–934444
Debt / EquityFinancial leverage2.05x1.45x0.36x0.24x0.29x
Net DebtTotal debt minus cash-$1M$22M$166M-$1M-$46M
Cash & Equiv.Liquid assets$7M$51M$1M$295M$183M
Total DebtShort + long-term debt$5M$73M$168M$294M$137M
Interest CoverageEBIT ÷ Interest expense-15.72x-7.96x-0.04x1.08x
GEVO leads this category, winning 5 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

TWST leads this category, winning 5 of 6 comparable metrics.

A $10,000 investment in TWST five years ago would be worth $5,015 today (with dividends reinvested), compared to $1,334 for CDXS. Over the past 12 months, BEAM leads with a +93.9% total return vs DYAI's -31.7%. The 3-year compound annual growth rate (CAGR) favors TWST at 63.5% vs DYAI's -24.7% — a key indicator of consistent wealth creation.

MetricDYAI logoDYAIDyadic Internatio…CDXS logoCDXSCodexis, Inc.GEVO logoGEVOGevo, Inc.BEAM logoBEAMBeam Therapeutics…TWST logoTWSTTwist Bioscience …
YTD ReturnYear-to-date-20.7%+60.2%-1.5%+16.0%+80.7%
1-Year ReturnPast 12 months-31.7%+13.2%+88.0%+93.9%+78.6%
3-Year ReturnCumulative with dividends-57.4%-24.3%+65.0%-5.6%+336.9%
5-Year ReturnCumulative with dividends-82.1%-86.7%-65.2%-55.6%-49.9%
10-Year ReturnCumulative with dividends-56.4%-19.6%-98.6%+67.8%+318.1%
CAGR (3Y)Annualised 3-year return-24.7%-8.9%+18.2%-1.9%+63.5%
TWST leads this category, winning 5 of 6 comparable metrics.

Risk & Volatility

Evenly matched — DYAI and TWST each lead in 1 of 2 comparable metrics.

DYAI is the less volatile stock with a 0.98 beta — it tends to amplify market swings less than TWST's 2.47 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. TWST currently trades 88.7% from its 52-week high vs DYAI's 55.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricDYAI logoDYAIDyadic Internatio…CDXS logoCDXSCodexis, Inc.GEVO logoGEVOGevo, Inc.BEAM logoBEAMBeam Therapeutics…TWST logoTWSTTwist Bioscience …
Beta (5Y)Sensitivity to S&P 5000.98x2.31x1.64x2.14x2.47x
52-Week HighHighest price in past year$1.35$3.87$2.97$36.44$66.00
52-Week LowLowest price in past year$0.66$0.96$1.01$15.35$23.30
% of 52W HighCurrent price vs 52-week peak+55.2%+66.7%+68.4%+86.4%+88.7%
RSI (14)Momentum oscillator 0–10041.460.453.560.957.0
Avg Volume (50D)Average daily shares traded75K2.4M4.5M2.0M1.2M
Evenly matched — DYAI and TWST each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: CDXS as "Buy", GEVO as "Buy", BEAM as "Buy", TWST as "Buy". Consensus price targets imply 93.8% upside for CDXS (target: $5) vs -15.4% for TWST (target: $50).

MetricDYAI logoDYAIDyadic Internatio…CDXS logoCDXSCodexis, Inc.GEVO logoGEVOGevo, Inc.BEAM logoBEAMBeam Therapeutics…TWST logoTWSTTwist Bioscience …
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuy
Price TargetConsensus 12-month target$5.00$3.50$40.83$49.50
# AnalystsCovering analysts14142713
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%0.0%+0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

GEVO leads in 2 of 6 categories (Valuation Metrics, Profitability & Efficiency). TWST leads in 1 (Total Returns). 2 tied.

Best OverallGevo, Inc. (GEVO)Leads 2 of 6 categories
Loading custom metrics...

DYAI vs CDXS vs GEVO vs BEAM vs TWST: Key Questions Answered

8 questions · data-driven answers · updated daily

01

Is DYAI or CDXS or GEVO or BEAM or TWST a better buy right now?

For growth investors, Gevo, Inc.

(GEVO) is the stronger pick with 849. 3% revenue growth year-over-year, versus 18. 6% for Codexis, Inc. (CDXS). Analysts rate Codexis, Inc. (CDXS) a "Buy" — based on 14 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — DYAI or CDXS or GEVO or BEAM or TWST?

Over the past 5 years, Twist Bioscience Corporation (TWST) delivered a total return of -49.

9%, compared to -86. 7% for Codexis, Inc. (CDXS). Over 10 years, the gap is even starker: TWST returned +318. 1% versus GEVO's -98. 6%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — DYAI or CDXS or GEVO or BEAM or TWST?

By beta (market sensitivity over 5 years), Dyadic International, Inc.

(DYAI) is the lower-risk stock at 0. 98β versus Twist Bioscience Corporation's 2. 47β — meaning TWST is approximately 152% more volatile than DYAI relative to the S&P 500. On balance sheet safety, Beam Therapeutics Inc. (BEAM) carries a lower debt/equity ratio of 24% versus 2% for Dyadic International, Inc. — giving it more financial flexibility in a downturn.

04

Which is growing faster — DYAI or CDXS or GEVO or BEAM or TWST?

By revenue growth (latest reported year), Gevo, Inc.

(GEVO) is pulling ahead at 849. 3% versus 18. 6% for Codexis, Inc. (CDXS). On earnings-per-share growth, the picture is similar: Beam Therapeutics Inc. grew EPS 82. 3% year-over-year, compared to 16. 7% for Dyadic International, Inc.. Over a 3-year CAGR, GEVO leads at 415. 1% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — DYAI or CDXS or GEVO or BEAM or TWST?

Twist Bioscience Corporation (TWST) is the more profitable company, earning -20.

6% net margin versus -166. 2% for Dyadic International, Inc. — meaning it keeps -20. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: GEVO leads at -11. 7% versus -274. 6% for BEAM. At the gross margin level — before operating expenses — BEAM leads at 84. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Which pays a better dividend — DYAI or CDXS or GEVO or BEAM or TWST?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

07

Is DYAI or CDXS or GEVO or BEAM or TWST better for a retirement portfolio?

For long-horizon retirement investors, Dyadic International, Inc.

(DYAI) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 98)). Codexis, Inc. (CDXS) carries a higher beta of 2. 31 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (DYAI: -56. 4%, CDXS: -19. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

08

What are the main differences between DYAI and CDXS and GEVO and BEAM and TWST?

These companies operate in different sectors (DYAI (Healthcare) and CDXS (Healthcare) and GEVO (Basic Materials) and BEAM (Healthcare) and TWST (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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