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ANVSAnnovis Bio, Inc.
$1.27$54M
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ANVS logo

Annovis Bio, Inc.

ANVS
NYSE · Biotechnology
$1.27
At close - Sep 23, 4:00 PM EDT - USD
Market Cap$54M
P/E-0.9x
52W High$5.50
Volume1.14M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Clinical Development Costs Threaten Annovis Bio Liquidity

Annovis Bio remains a high-risk, pre-revenue biotechnology firm entirely dependent on external financing to advance its Buntanetap program. The company faces a critical liquidity inflection point as R&D expenditures surged to $16.7 billion in 2026Q1, significa...

GrowthMixed
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

ANVS price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

6/12 Beats

EPS beat 6 of last 12 quarters

02

Valuation risk

-102% Peers

P/E is 102% below peer median

03

Market leadership

RS 6 · Lag

Laggard (Underperforming 94% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 11

Market performance

Price History →

Trailing total returns as of 9/24/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ANVS-65.21%
S&P 500 (^GSPC)+12.39%
1-Year Return
ANVS-43.05%
S&P 500 (^GSPC)+15.77%
3-Year Return
ANVS-86.72%
S&P 500 (^GSPC)+80.77%
5-Year Return
ANVS-96.42%
S&P 500 (^GSPC)+67.47%

Growth & profitability

Annual revenue & EPS trend
Revenue
-
Net income
-$29M-17.3% YoY
Free cash flow
-$25.62B-17.0% YoY
Operating margin
-
ROIC (TTM)-
Avg ROIC 5Y-
ROE (TTM)-220.6%
Piotroski Score2 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate6/12 (50%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 14, 2026
-$0.40+11.8%
vs -$0.45
—
vs —
Q2 2026
May 15, 2026
-$0.63-59.5%
vs -$0.40
—
vs —
Q2 2026
Mar 16, 2026
-$0.39-26.5%
vs -$0.31
—
vs —
Q4 2025
Nov 12, 2025
-$0.37-2.8%
vs -$0.36
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Zacks Investment Research·Sep 8, 2026
Annovis Bio (ANVS) Loses 26.5% in 4 Weeks, Here's Why a Trend Reversal May be Around the Corner

Annovis Bio (ANVS) has become technically an oversold stock now, which implies exhaustion of the heavy selling pressure on it. This, combined with strong agreement among Wall Street analysts in revising earnings estimates higher, indicates a potential trend reversal for the stock in the near term.

MarketBeat·Sep 3, 2026
Annovis Bio Targets March 2027 Alzheimer's Readout, Prepares Rolling NDA

Annovis Bio NYSE: ANVS said it expects to report top-line results from the six-month portion of its pivotal Phase III Alzheimer's disease trial in March 2027, while preparing a rolling new drug application, or NDA, that management said could begin in May if the study meets its efficacy requirements.

GlobeNewsWire·Aug 25, 2026
Annovis to Host Corporate Update Webinar on September 2, 2026

MALVERN, Pa., Aug. 25, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced it will host a corporate update webinar followed by a live Q&A session.

GlobeNewsWire·Aug 14, 2026
Annovis Provides Corporate Updates and Second Quarter 2026 Financial Results

MALVERN, Pa., Aug. 14, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today provided business updates and reported financial results for the second quarter ended June 30, 2026.

Filtered for Annovis Bio, Inc.More Headlines
04

Compare before deciding

Benchmark ANVS against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Annovis Bio, Inc. (ANVS)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ANVS logoANVSAnnovis Bio, Inc.Current
$1.27$54.03M-0.91——-220.61%—
SAVA logoSAVACassava Sciences, Inc.
$0.94$45.26M-1.80——-95.77%—
PRTA logoPRTAProthena Corporation plc
$8.68$454.43M-1.92-92.84%-80.67%-14.98%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$25.43$4.35B11.1011.87%33.42%32.39%—
AVXL logoAVXLAnavex Life Sciences Corp.
$2.35$217.78M-4.35——-30.07%—
ATHA logoATHAAthira Pharma, Inc.
$4.34$17.12M-0.18——-411.58%—

Compare ANVS vs Peers

Annovis Bio, Inc. (ANVS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SAVA

Most directly comparable listed peer for ANVS.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ANVS against a more recognizable public peer.

Peer Set

Compare Top 5

vs SAVA, PRTA, ACAD, AVXL

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

ANVS SEC Filings & Documents

Annovis Bio, Inc. (ANVS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 14, 2026·SEC

Material company update

Jul 10, 2026·SEC

Material company update

Jun 17, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 13, 2026·SEC

FY 2025

Mar 21, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 14, 2026·SEC

FY 2026

May 15, 2026·SEC

FY 2025

Nov 12, 2025·SEC

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ANVS Frequently Asked Questions

Annovis Bio, Inc. (ANVS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is ANVS profitable?

Annovis Bio, Inc. (ANVS) reported a net loss of $49.5M for fiscal year 2025.

Dividend & Returns
What is ANVS's return on equity?

Annovis Bio, Inc. (ANVS) has a return on equity (ROE) of -220.6%. Negative ROE indicates the company is unprofitable.

What is Annovis Bio, Inc.'s free cash flow?

Annovis Bio, Inc. (ANVS) had negative free cash flow of $43.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ANVS back in 2017?

Total return calculator · dividends reinvested · 9+ years of data

See returns →