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ANVS
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ANVSAnnovis Bio, Inc.
$0.84$36M
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ANVS logo

Annovis Bio, Inc.

ANVS
NYSE · Neuroscience Biotech
$0.84
At close - Nov 6, 4:00 PM EST - USD
Market Cap$36M
P/E-0.6x
52W High$5.50
Volume11.27M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Clinical Development Costs Threaten Annovis Bio Liquidity

Annovis Bio remains a high-risk, pre-revenue biotechnology firm entirely dependent on external financing to advance its Buntanetap program. The company faces a critical liquidity inflection point as R&D expenditures surged to $16.7 billion in 2026Q1, significantly outpacing historical averages.

GrowthMixed
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

ANVS price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

6/12 Beats

EPS beat 6 of last 12 quarters

02

Valuation risk

-102% Peers

P/E is 102% below peer median

03

Market leadership

RS 10 · Lag

Laggard (Underperforming 90% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 11

Market performance

Price History →

Trailing total returns as of 11/8/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ANVS-77.34%
S&P 500 (^GSPC)+7.63%
1-Year Return
ANVS-58.44%
S&P 500 (^GSPC)+9.69%
3-Year Return
ANVS-86.85%
S&P 500 (^GSPC)+83.97%
5-Year Return
ANVS-97.80%
S&P 500 (^GSPC)+71.18%

Growth & profitability

Annual revenue & EPS trend
Revenue FY25
-
Net income FY25
-$29M-17.3% YoY
Free cash flow FY25
-$26M-17.0% YoY
Operating margin FY25
-
ROIC (FY25)-
Avg ROIC 5Y-
ROE (TTM)-686%
Piotroski Score3 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate6/12 (50%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 14, 2026
-$0.40+11.8%
vs -$0.45
—
vs —
Q2 2026
May 15, 2026
-$0.63-59.5%
vs -$0.40
—
vs —
Q2 2026
Mar 16, 2026
-$0.39-26.5%
vs -$0.31
—
vs —
Q4 2025
Nov 12, 2025
-$0.37-2.8%
vs -$0.36
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

4 Stories
GlobeNewsWire·3d ago
Annovis Announces Pricing of $21.0 Million Public Offering

MALVERN, Pa., Nov. 05, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced the pricing of an underwritten public offering of (i) 19,000,000 shares of its common stock and, in lieu of common stock to certain investors that so chose, pre-funded warrants (the “Pre-Funded Warrants”) to purchase up to 2,000,000 shares of its common stock, and (ii) accompanying warrants to purchase up to 21,000,000 shares of common stock.

GlobeNewsWire·4d ago
Annovis Announces Launch of Proposed Public Offering

MALVERN, Pa., Nov. 04, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced a proposed underwritten public offering in which it intends to offer and sell (i) shares of its common stock or, in lieu of common stock to certain investors that so choose, pre-funded warrants to purchase shares of its common stock, and (ii) accompanying warrants to purchase shares of common stock. The shares of common stock (or pre-funded warrants in lieu thereof) and the accompanying warrants will be issued separately but can only be purchased together in the proposed offering. All of the securities in the proposed offering will be offered by Annovis. The proposed offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

GlobeNewsWire·Oct 30, 2026
Annovis Bio, Inc. Receives Continued Listing Standard Notice from the NYSE

MALVERN, Pa., Oct. 30, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced that on October 29, 2026, it received notice (the “Notice”) from the New York Stock Exchange (NYSE) that it is no longer in compliance with the NYSE continued listing standards set forth in Section 802.01B of the NYSE's Listed Company Manual due to the fact that the Company's average market capitalization over a consecutive 30 trading-day period was less than $50 million while its stockholders' equity was less than $50 million.

GlobeNewsWire·Oct 29, 2026
Annovis to Participate in U.S. Biotech Day 2026 and Pharma Partnering Summit 2026

MALVERN, Pa., Oct. 29, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced that Maria Maccecchini, PhD, Founder, President and CEO of Annovis, will participate and present in two industry events in November.

Filtered for Annovis Bio, Inc.More Headlines
04

Compare before deciding

Benchmark ANVS against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Annovis Bio, Inc. (ANVS)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ANVS logoANVSAnnovis Bio, Inc.Current
$0.84$35.94M-0.64——-685.96%—
PRTA logoPRTAProthena Corporation plc
$7.97$417.26M-17.11-92.84%-45.43%-8.34%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$21.23$3.64B10.2811.87%30.13%28.03%—
AVXL logoAVXLAnavex Life Sciences Corp.
$1.15$106.57M-4.37——-21.11%—
BIIB logoBIIBBiogen Inc.
$248.35$36.69B105.481.39%3.38%1.86%—
LLY logoLLYEli Lilly and Company
$1354.00$1.28T43.8644.7%31.9%83.65%0.44%

Compare ANVS vs Peers

Annovis Bio, Inc. (ANVS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PRTA

Most directly comparable listed peer for ANVS.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ANVS against a more recognizable public peer.

Peer Set

Compare Top 5

vs PRTA, ACAD, AVXL, BIIB

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

ANVS SEC Filings & Documents

Annovis Bio, Inc. (ANVS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 14, 2026·SEC

Material company update

Jul 10, 2026·SEC

Material company update

Jun 17, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 13, 2026·SEC

FY 2025

Mar 21, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 14, 2026·SEC

FY 2026

May 15, 2026·SEC

FY 2025

Nov 12, 2025·SEC

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ANVS Frequently Asked Questions

Annovis Bio, Inc. (ANVS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is ANVS profitable?

No. Annovis Bio, Inc. (ANVS) reported a net loss of $49.5M over the trailing twelve months.

Dividend & Returns
What is ANVS's return on equity?

Annovis Bio, Inc. (ANVS) had a return on equity (ROE) of -686.0% over the trailing twelve months. A negative ROE means the company lost money over the period.

What is Annovis Bio, Inc.'s free cash flow?

Annovis Bio, Inc. (ANVS) had negative free cash flow of $43.3M over the trailing twelve months.

What if you invested $1,000 in ANVS back in 2017?

Total return calculator · dividends reinvested · 9+ years of data

See returns →