Agenus Inc. (AGEN) P/E Ratio History
Deep ValueTrading at -894.1x · 0th percentile of 5-year range · Significant discount to historical valuation · Data 2022–2026
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P/E Ratio Analysis
As of June 22, 2026, Agenus Inc. (AGEN) trades at a price-to-earnings ratio of -894.1x, with a stock price of $3.04 and trailing twelve-month earnings per share of $1.69.
The current P/E is 3470% below its 5-year average of 26.5x. Over the past five years, AGEN's P/E has ranged from a low of 2.0x to a high of 51.1x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 22.1x, AGEN trades at a 4142% discount to its sector peers. The sector includes 233 companies with P/E ratios ranging from 0.0x to 194.5x.
Relative to the broader market, AGEN trades at a notable discount to the S&P 500 median P/E of 24.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our AGEN DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
AGEN Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
AGEN P/E vs Peers
Oncology Therapeutics Developers peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $21B | 16.2Lowest | - | +4173%Best | |
| $13B | 18.5 | 0.36Best | +58% | |
| $8B | 32.2 | - | -34% | |
| $8B | 19.6 | - | +1747% |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
AGEN Historical P/E Data (2022–2026)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2026 Q1 | - | $3.34 | $1.66 | 2.0x | -92% |
| FY2022 Q2 | - | $38.80 | $0.76 | 51.1x | +92% |
Average P/E for displayed period: 26.5x
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
4+ years return with dividends reinvested.
DCA Calculator
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Peer Comparison
Compare growth, multiples, and margins vs sector.
AGEN — Frequently Asked Questions
Quick answers to the most common questions about buying AGEN stock.
What is AGEN's P/E ratio?
Agenus Inc. (AGEN) trailing twelve-month P/E ratio is -894.1x, based on TTM diluted EPS of $1.69. The 5-year average P/E is 26.5x and the historical range spans 2.0x to 51.1x.
Is AGEN stock overvalued or undervalued?
AGEN trades at -894.1x P/E, below its 5-year average of 26.5x. At the 0th percentile of its historical range (2.0x–51.1x), the stock is priced at a discount to its own history.
Is AGEN stock expensive?
No, AGEN is not expensive on a historical basis. The current P/E of -894.1x is below the 5-year average of 26.5x and sits at the 0th percentile of its valuation range.
What is AGEN's historical P/E range?
Over the past 5 years, AGEN's P/E ratio has ranged from 2.0x to 51.1x, with a median of 51.1x and an average of 26.5x. The current P/E of -894.1x places the stock at the 0th percentile of this range. Full historical data spans 2022–2026.
How does AGEN's P/E compare to the S&P 500?
AGEN trades at -894.1x P/E versus the S&P 500 median of 24.3x. The 3779% discount to the market suggests lower growth expectations or perceived higher risk.
How does AGEN's valuation compare to Healthcare peers?
Agenus Inc. P/E of -894.1x compares to the Healthcare sector median of 22.1x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is AGEN's PEG ratio?
AGEN PEG ratio is N/A, based on a P/E of -894.1x and EPS growth of 100.0%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is AGEN's earnings yield?
AGEN earnings yield is N/A, the inverse of its -894.1x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.