Free cash flow remains highly inconsistent, oscillating between a positive $98.0 million in 2025Q4 and a negative $40.3 million in 2025Q2, reflecting the erratic timing of milestone-related cash inflows.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|
| Cash from Operations | 4.48M | 19.7M | -135.34M | -120.8M | -73.59M | -45.92M | -14.16M | -69.52M | -48.51M | -19.44M | -9.03M | -9.67M | 14.6M | -5.8M |
| Operating CF Margin % | - | 8.4% | -148.27% | -704.09% | -715.4% | -72.69% | -18.88% | -868.96% | -970.12% | -194.38% | -54.12% | -55.03% | 92.2% | -105.71% |
| Operating CF Growth % | -155.11% | 114.55% | -12.03% | -64.15% | -60.26% | -224.36% | 79.64% | -43.32% | -149.54% | -115.26% | 6.61% | -166.21% | 351.95% | - |
| Net Income | -26.79M | 49.61M | -145.23M | -163.62M | -128.72M | -57.8M | -19.93M | -97.34M | -61.66M | -30.07M | -4.26M | -5.41M | 3.53M | -5.54M |
| Depreciation & Amortization | 2.43M | 2.42M | 2.4M | 2.38M | 2.33M | 2.09M | 559K | 514K | 315K | 183K | 233K | 274K | 308K | 580K |
| Stock-Based Compensation | 41.12M | 36.07M | 34.05M | 33.2M | 27.36M | 15.35M | 11.5M | 12.41M | 9.96M | 4.38M | 1.16M | 604K | 160K | 151K |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1.23M | 1.38M | 757K | 1.28M | 62K | -621K |
| Other Non-Cash Items | 78.61M | 12.31M | 39.77M | 7.56M | 18.6M | 1.93M | 487K | -1.96M | 646K | 619K | 105K | 110K | 1.27M | 886K |
| Working Capital Changes | -90.89M | -80.72M | -66.33M | -324K | 6.84M | -7.49M | -6.77M | 16.85M | 3.46M | 4.08M | -7.03M | -6.53M | 9.27M | -1.25M |
| Change in Receivables | -7.86M | 6.92M | -33.91M | 0 | -543K | -876K | 0 | 174K | 1.43M | 1.23M | 1K | 229K | -1.46M | 268K |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -237.97M | -5.34M | 343K | -489K | 132K |
| Change in Payables | -81.11M | -87.33M | -33.84M | 10.94M | 9.7M | -4.74M | 0 | 0 | 7.08M | 2.22M | 1.25M | 1.95M | 482K | -255K |
| Cash from Investing | 248.17M | 228.03M | 95.4M | 144.75M | -394.85M | 38.84M | 94.47M | 131.43M | -142.45M | -243.06M | -50K | -238K | -140K | -37K |
| Capital Expenditures | -69K | -87K | -358K | -807K | -358K | -1.37M | -569K | -805K | -1.06M | -290K | -50K | -238K | -145K | -37K |
| CapEx % of Revenue | 0.03% | 0.04% | 0.39% | 4.7% | 3.48% | 2.16% | 0.76% | 10.06% | 21.26% | 2.9% | 0.3% | 1.35% | 0.92% | 0.67% |
| Acquisitions | 0 | 0 | 0 | 0 | 394.49M | 0 | 0 | 0 | 347.54M | 290.9M | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | 0 | 0 | 0 | -394.49M | 15K | 0 | 0 | -347.54M | -290.9M | 0 | 0 | 5K | 0 |
| Cash from Financing | -102.81M | -132.61M | 127.05M | -59.3M | 44.02M | 252.3M | -879K | -4.49M | 223.36M | 292.45M | 8.63M | 39.4M | 4.92M | 1.96M |
| Debt Issued (Net) | -66.6M | -76.8M | 34.77M | -11.73M | 0 | 0 | -1.38M | -7.5M | -6.88M | 0 | 10M | 0 | 5M | 1.96M |
| Equity Issued (Net) | -36.21M | -54.37M | 100.39M | -47.53M | 11.83M | 2.55M | 496K | 3.01M | 227.48M | 292.54M | -1K | 40.85M | 0 | 4K |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | -64.2M | -68.63M | -456K | -50M | 0 | 0 | 0 | 0 | 0 | 0 | -1K | 0 | 0 | 0 |
| Other Financing | 0 | -1.45M | -8.1M | -43K | 32.19M | 249.75M | 0 | 0 | 2.76M | -84K | -1.37M | -1.45M | -85K | 0 |
| Net Change in Cash | 149.83M | 115.12M | 87.11M | -35.34M | -424.42M | 245.21M | 79.44M | 57.42M | 32.41M | 29.96M | -452K | 29.5M | 19.38M | -3.87M |
| Free Cash Flow | 4.41M | 19.61M | -135.69M | -121.61M | -73.95M | -47.29M | -14.73M | -70.32M | -49.57M | -19.73M | -9.08M | -9.91M | 14.46M | -5.83M |
| FCF Margin % | 1.9% | 8.36% | -148.66% | -708.79% | -718.88% | -74.85% | -19.63% | -879.03% | -991.38% | -197.28% | -54.42% | -56.38% | 91.29% | -106.38% |
| FCF Growth % | 104.04% | 114.45% | -11.58% | -64.44% | -56.39% | -221.11% | 79.06% | -41.87% | -151.26% | -117.27% | 8.35% | -168.52% | 347.87% | - |
| FCF per Share | 0.15 | 0.63 | -4.78 | -4.52 | -2.63 | -1.72 | -0.54 | -2.60 | -2.01 | -1.00 | -3.44 | -3.88 | 5.83 | -5.24 |
| FCF Conversion (FCF/Net Income) | -0.16x | -1.49x | 0.93x | 0.74x | 0.57x | 0.79x | 0.71x | 0.71x | 0.79x | 0.65x | 2.12x | 1.79x | 62.94x | 1.05x |
| Interest Paid | 20.83M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 79K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical Pipeline Execution Risk
According to recent SEC filings, the relationship between net income and operating cash flow is highly volatile, with OCF/NI ratios swinging from 3.06 in 2024Q4 to -1.81 in 2025Q3, reflecting the erratic timing of milestone-driven revenue recognition versus actual cash inflows.
The wide divergence between accounting earnings and cash generation suggests that reported net income is a poor proxy for the company's underlying liquidity health. Investors should monitor whether future cash flows can decouple from lumpy milestone events to provide a more consistent funding source for ongoing R&D.
As reported in financial statements, free cash flow remains deeply inconsistent, oscillating between a positive $98.0 million in 2025Q4 and a negative $40.3 million in 2025Q2, highlighting the company's persistent struggle to maintain self-sustaining operations outside of sporadic, non-recurring partnership payments.
The inability to generate positive free cash flow on a consistent basis implies that the company remains fundamentally dependent on external capital or intermittent licensing windfalls. This trajectory warrants caution, as the current cash burn rate could accelerate if clinical trial costs for the internal pipeline continue to escalate.
Based on ANAB's reported figures, working capital changes have been a primary driver of cash flow variance, notably with a $73.6 million outflow in 2025Q3 followed by a $19.9 million inflow in 2025Q4, indicating significant sensitivity to the timing of milestone-related receivables.
These dramatic fluctuations in working capital suggest that the company's cash position is highly susceptible to the administrative and contractual timing of partner payments. Analysts should interpret these swings as evidence of a business model that lacks the operational maturity to smooth out its cash conversion cycle.
Data from financial disclosures reveals that despite persistent operating cash outflows, the company utilized $51.1 million for share repurchases in 2025Q2, a move that appears aggressive given the ongoing need to fund high-cost clinical development programs through non-dilutive milestone capital.
The decision to return capital to shareholders while the core business remains in a cash-burning phase may indicate management's confidence in the royalty floor, yet it simultaneously reduces the liquidity buffer available for pipeline setbacks. Investors should scrutinize whether this capital allocation strategy aligns with the long-term objective of achieving commercial-stage independence.
Quick answers to the most common questions about buying ANAB stock.
AnaptysBio, Inc. (ANAB) generated $19.7M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
AnaptysBio, Inc. (ANAB) generated $19.6M in free cash flow in 2025. Free cash flow is the cash left over after capital expenditures, which can be used to pay dividends, repurchase shares, or pay down debt.
AnaptysBio, Inc. (ANAB) spent $0.1M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
In 2025, AnaptysBio, Inc. (ANAB) spent $68.6M on share repurchases. This shows the company's commitment to returning capital to its equity investors.