Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in ANAB held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 7.9M | $437.0M | 0.0% | 18.274% | 18.55% |
| 2 | BlackRock, Inc. | 1.7M | $93.2M | -3.1% | 3.899% | 0.00% |
| 3 | TANG CAPITAL MANAGEMENT LLC | 1.3M | $73.8M | -0.1% | 3.086% | 3.75% |
| 4 | MORGAN STANLEY | 994K | $55.1M | -3.9% | 2.305% | 0.00% |
| 5 | STATE STREET CORP | 992K | $55.0M | -5.8% | 2.301% | 0.00% |
| 6 | Affinity Asset Advisors, LLC | 940K | $52.1M | +111.4% | 2.180% | 3.03% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 853K | $47.3M | β | 1.978% | 0.00% |
| 8 | Palo Alto Investors LP | 638K | $35.4M | -7.5% | 1.480% | 5.41% |
| 9 | 683 Capital Management, LLC | 625K | $34.7M | -3.6% | 1.449% | 2.68% |
| 10 | D. E. Shaw & Co., Inc. | 579K | $32.1M | -13.6% | 1.343% | 0.03% |
| 11 | First Light Asset Management, LLC | 565K | $31.4M | -12.5% | 1.311% | 2.81% |
| 12 | Sanofi | 822K | $30.4M | 0.0% | 1.906% | 9.04% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 520K | $28.9M | +10.8% | 1.206% | 0.00% |
| 14 | VANGUARD PORTFOLIO MANAGEMENT LLC | 520K | $28.8M | β | 1.206% | 0.00% |
| 15 | BANK OF AMERICA CORP /DE/ | 501K | $27.8M | +283.2% | 1.162% | 0.00% |
| 16 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 492K | $27.3M | -12.1% | 1.141% | 0.01% |
| 17 | MILLENNIUM MANAGEMENT LLC | 476K | $26.4M | -41.5% | 1.103% | 0.02% |
| 18 | FMR LLC | 473K | $26.2M | +1643.8% | 1.096% | 0.00% |
| 19 | TWO SIGMA INVESTMENTS, LP | 465K | $25.8M | +81.2% | 1.079% | 0.02% |
| 20 | FEDERATED HERMES, INC. | 364K | $20.2M | +21.6% | 0.844% | 0.03% |
| 21 | Woodline Partners LP | 344K | $19.1M | -31.3% | 0.798% | 0.07% |
| 22 | GOLDMAN SACHS GROUP INC | 333K | $18.5M | -16.6% | 0.772% | 0.00% |
| 23 | Synergy Financial Management, LLC | 317K | $17.6M | β | 0.735% | 1.87% |
| 24 | Nuveen, LLC | 316K | $17.5M | -0.2% | 0.733% | 0.00% |
| 25 | Squarepoint Ops LLC | 268K | $14.8M | +66.5% | 0.621% | 0.02% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in ANAB β a direct measure of their conviction.
Filings activity in ANAB during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new ANAB position in Q1 2026
Institutions that fully closed their ANAB position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 199 | +12% | 63.38% | +4.57 pp | $1.53B | +7.8% |
| Q4 2025 | 177 | +9.9% | 58.81% | +19.92 pp | $1.42B | +51% |
| Q3 2025 | 161 | +8.1% | 38.89% | +5.64 pp | $940M | +17% |
| Q2 2025 | 149 | 2.6% | 33.25% | +3.48 pp | $804M | +12% |
| Q1 2025 | 153 | +13% | 29.77% | +10.99 pp | $720M | +59% |
| Q4 2024 | 136 | 14% | 18.78% | 45.64 pp | $454M | 71% |
| Q3 2024 | 159 | +19% | 64.42% | +34.61 pp | $1.56B | +116% |
| Q2 2024 | 134 | β | 29.81% | β | $721M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying ANAB stock.
Based on Q1 2026 13F filings, institutional ownership of AnaptysBio, Inc. stands at 63.4%, held across 199 reporting institutions.
EcoR1 Capital, LLC is the largest reported institutional holder of ANAB, with approximately 7,880,094 shares worth $0.44B as of Q1 2026.
Yes β 2 widely-followed marquee investors appear among the top 25 institutional holders of ANAB, including MILLENNIUM MANAGEMENT LLC, TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for ANAB is 69 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
49 institutions opened new positions in ANAB during Q1 2026, while 27 fully exited. 112 added to existing positions and 37 trimmed.
ANAB institutional ownership rose by 4.57 percentage points quarter-over-quarter, with a net change of +22 holders.
The top 10 institutions account for 59.8% of all reported 13F value in ANAB, and the top 25 account for 83.3%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
AnaptysBio, Inc. (ANAB) Institutional Ownership