Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in DSGN held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | SR ONE CAPITAL MANAGEMENT, LP | 6.5M | $69.4M | 0.0% | 10.450% | 7.59% |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 3.0M | $31.6M | +103.4% | 4.760% | 0.34% |
| 3 | Point72 Asset Management, L.P. | 2.7M | $29.0M | -49.3% | 4.359% | 0.04% |
| 4 | BAKER BROS. ADVISORS LP | 2.6M | $27.5M | +15.8% | 4.140% | 0.16% |
| 5 | BlackRock, Inc. | 2.1M | $22.7M | +0.8% | 3.416% | 0.00% |
| 6 | Logos Global Management LP | 1.9M | $20.7M | -22.0% | 3.122% | 1.04% |
| 7 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1.7M | $18.6M | +47.9% | 2.794% | 0.14% |
| 8 | Vivo Capital, LLC | 1.6M | $17.2M | 0.0% | 2.582% | 1.43% |
| 9 | Almitas Capital LLC | 1.5M | $16.3M | -0.0% | 2.450% | 3.68% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 1.3M | $14.4M | — | 2.161% | 0.00% |
| 11 | Woodline Partners LP | 962K | $10.2M | +1.8% | 1.540% | 0.04% |
| 12 | Trails Edge Capital Partners, LP | 852K | $9.1M | — | 1.364% | 2.08% |
| 13 | FMR LLC | 798K | $8.5M | +3.5% | 1.278% | 0.00% |
| 14 | Kynam Capital Management, LP | 785K | $8.3M | 0.0% | 1.256% | 0.52% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 693K | $7.4M | +1.9% | 1.109% | 0.00% |
| 16 | STATE STREET CORP | 660K | $7.0M | +1.8% | 1.056% | 0.00% |
| 17 | MORGAN STANLEY | 657K | $7.0M | -6.5% | 1.051% | 0.00% |
| 18 | GOLDMAN SACHS GROUP INC | 505K | $5.4M | +86.5% | 0.808% | 0.00% |
| 19 | D. E. Shaw & Co., Inc. | 470K | $5.0M | +7.1% | 0.753% | 0.00% |
| 20 | DIMENSIONAL FUND ADVISORS LP | 432K | $4.6M | +45.0% | 0.691% | 0.00% |
| 21 | RENAISSANCE TECHNOLOGIES LLC | 408K | $4.3M | +42.2% | 0.654% | 0.01% |
| 22 | NORTHERN TRUST CORP | 300K | $3.2M | +4.8% | 0.481% | 0.00% |
| 23 | JACOBS LEVY EQUITY MANAGEMENT, INC | 289K | $3.1M | +48.7% | 0.463% | 0.01% |
| 24 | KENNEDY CAPITAL MANAGEMENT, INC. | 272K | $2.9M | +442.9% | 0.435% | 0.06% |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 241K | $2.6M | +1.9% | 0.387% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in DSGN — a direct measure of their conviction.
Filings activity in DSGN during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new DSGN position in Q1 2026
Institutions that fully closed their DSGN position in Q1 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 123 | +5.1% | 57.66% | +6.61 pp | $395M | +13% |
| Q4 2025 | 117 | +23% | 51.05% | +13.87 pp | $350M | +37% |
| Q3 2025 | 95 | +1.1% | 37.18% | +20.59 pp | $255M | +124% |
| Q2 2025 | 94 | 4.1% | 16.59% | 1.83 pp | $114M | 9.9% |
| Q1 2025 | 98 | +4.3% | 18.42% | 10.05 pp | $126M | 35% |
| Q4 2024 | 94 | 6.0% | 28.47% | +4.52 pp | $195M | +19% |
| Q3 2024 | 100 | +4.2% | 23.95% | +8.86 pp | $164M | +59% |
| Q2 2024 | 96 | — | 15.09% | — | $103M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying DSGN stock.
Based on Q1 2026 13F filings, institutional ownership of Design Therapeutics, Inc. stands at 57.7%, held across 123 reporting institutions.
SR ONE CAPITAL MANAGEMENT, LP is the largest reported institutional holder of DSGN, with approximately 6,526,476 shares worth $0.07B as of Q1 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of DSGN, including Point72 Asset Management, L.P., RENAISSANCE TECHNOLOGIES LLC.
Our composite Smart Money Score for DSGN is 68 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
21 institutions opened new positions in DSGN during Q1 2026, while 15 fully exited. 80 added to existing positions and 20 trimmed.
DSGN institutional ownership rose by 6.61 percentage points quarter-over-quarter, with a net change of +6 holders.
The top 10 institutions account for 67.7% of all reported 13F value in DSGN, and the top 25 account for 90.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Design Therapeutics, Inc. (DSGN) Institutional Ownership