Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in ENTA held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON GROUP PLC | 3.8M | $47.7M | +1.5% | 16.299% | 0.02% |
| 2 | BlackRock, Inc. | 3.1M | $39.2M | +0.9% | 13.369% | 0.00% |
| 3 | FARALLON CAPITAL MANAGEMENT LLC | 2.9M | $36.3M | +3.6% | 12.370% | 0.24% |
| 4 | Deep Track Capital, LP | 2.0M | $24.7M | 0.0% | 8.429% | 0.51% |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $14.9M | β | 5.074% | 0.00% |
| 6 | VANGUARD PORTFOLIO MANAGEMENT LLC | 949K | $12.0M | β | 4.087% | 0.00% |
| 7 | Spruce Street Capital LP | 933K | $11.8M | +139.3% | 4.017% | 2.83% |
| 8 | MILLENNIUM MANAGEMENT LLC | 882K | $11.1M | +31.6% | 3.799% | 0.01% |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 725K | $9.2M | +12.3% | 3.123% | 0.00% |
| 10 | RENAISSANCE TECHNOLOGIES LLC | 665K | $8.4M | +3.6% | 2.865% | 0.01% |
| 11 | STATE STREET CORP | 562K | $7.1M | +7.3% | 2.421% | 0.00% |
| 12 | Hillsdale Investment Management Inc. | 436K | $5.5M | +3.1% | 1.876% | 0.15% |
| 13 | AQR CAPITAL MANAGEMENT LLC | 313K | $4.0M | +33.4% | 1.349% | 0.00% |
| 14 | MORGAN STANLEY | 310K | $3.9M | -8.9% | 1.333% | 0.00% |
| 15 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 295K | $3.7M | +34.9% | 1.270% | 0.00% |
| 16 | CITADEL ADVISORS LLC | 293K | $3.7M | +163.3% | 1.263% | 0.00% |
| 17 | TWO SIGMA INVESTMENTS, LP | 267K | $3.4M | -6.3% | 1.152% | 0.00% |
| 18 | GOLDMAN SACHS GROUP INC | 265K | $3.3M | +21.1% | 1.142% | 0.00% |
| 19 | NORTHERN TRUST CORP | 241K | $3.0M | +4.8% | 1.038% | 0.00% |
| 20 | MARSHALL WACE, LLP | 210K | $2.7M | -45.5% | 0.905% | 0.00% |
| 21 | DIMENSIONAL FUND ADVISORS LP | 203K | $2.6M | -4.0% | 0.876% | 0.00% |
| 22 | Invesco Ltd. | 182K | $2.3M | -28.3% | 0.784% | 0.00% |
| 23 | VANGUARD FIDUCIARY TRUST CO | 176K | $2.2M | β | 0.758% | 0.00% |
| 24 | EverSource Wealth Advisors, LLC | 55K | $1.6M | +4655.0% | 0.235% | 0.05% |
| 25 | Connor, Clark & Lunn Investment Management Ltd. | 126K | $1.6M | +21.0% | 0.542% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in ENTA β a direct measure of their conviction.
Filings activity in ENTA during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new ENTA position in Q1 2026
Institutions that fully closed their ENTA position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 130 | 0.8% | 105.42% | 24.65 pp | $291M | 19% |
| Q4 2025 | 131 | +14% | 130.07% | +65.37 pp | $359M | +101% |
| Q3 2025 | 115 | +11% | 64.70% | +27.10 pp | $179M | +72% |
| Q2 2025 | 104 | 4.6% | 37.60% | +6.90 pp | $104M | +22% |
| Q1 2025 | 109 | +1.9% | 30.70% | 3.91 pp | $85M | 11% |
| Q4 2024 | 107 | 2.7% | 34.61% | 33.65 pp | $96M | 49% |
| Q3 2024 | 110 | +10% | 68.26% | 22.93 pp | $189M | 25% |
| Q2 2024 | 100 | β | 91.19% | β | $252M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying ENTA stock.
Based on Q1 2026 13F filings, institutional ownership of Enanta Pharmaceuticals, Inc. stands at 105.4%, held across 130 reporting institutions.
JANUS HENDERSON GROUP PLC is the largest reported institutional holder of ENTA, with approximately 3,784,055 shares worth $0.05B as of Q1 2026.
Yes β 4 widely-followed marquee investors appear among the top 25 institutional holders of ENTA, including MILLENNIUM MANAGEMENT LLC, RENAISSANCE TECHNOLOGIES LLC, CITADEL ADVISORS LLC, TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for ENTA is 47 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
24 institutions opened new positions in ENTA during Q1 2026, while 25 fully exited. 24 added to existing positions and 80 trimmed.
ENTA institutional ownership fell by 24.65 percentage points quarter-over-quarter, with a net change of -1 holders.
The top 10 institutions account for 73.9% of all reported 13F value in ENTA, and the top 25 account for 91.3%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Enanta Pharmaceuticals, Inc. (ENTA) Institutional Ownership