Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in GPCR held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7.8M | $419.2M | -7.1% | 13.567% | 0.02% |
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 7.4M | $396.1M | +1.6% | 12.819% | 0.07% |
| 3 | Avoro Capital Advisors LLC | 6.6M | $351.8M | 0.0% | 11.388% | 3.16% |
| 4 | Jupiter Topco LLC | 5.2M | $279.3M | — | 9.040% | 0.11% |
| 5 | Deep Track Capital, LP | 4.7M | $254.4M | +10.8% | 8.234% | 3.70% |
| 6 | BVF INC/IL | 3.4M | $180.7M | -2.7% | 5.849% | 4.62% |
| 7 | MORGAN STANLEY | 2.8M | $150.6M | +21.7% | 4.875% | 0.01% |
| 8 | ORBIMED ADVISORS LLC | 2.2M | $118.6M | +49.8% | 3.838% | 2.20% |
| 9 | PRINCIPAL FINANCIAL GROUP INC | 1.8M | $94.1M | -0.1% | 3.045% | 0.05% |
| 10 | AMERICAN CENTURY COMPANIES INC | 1.7M | $90.3M | +17.0% | 2.922% | 0.04% |
| 11 | RTW INVESTMENTS, LP | 1.6M | $86.3M | — | 2.792% | 0.74% |
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1.6M | $83.4M | -1.5% | 2.698% | 0.48% |
| 13 | BAKER BROS. ADVISORS LP | 1.4M | $76.9M | 0.0% | 2.489% | 0.39% |
| 14 | Casdin Capital, LLC | 1.2M | $63.1M | 0.0% | 2.041% | 3.16% |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1.1M | $58.3M | +41.4% | 1.887% | 0.61% |
| 16 | CAPITOLIS LIQUID GLOBAL MARKETS LLC | 1.0M | $55.9M | -9.6% | 1.808% | 0.24% |
| 17 | Siren, L.L.C. | 873K | $46.9M | -34.3% | 1.516% | 0.95% |
| 18 | PACIFIC HEIGHTS ASSET MANAGEMENT LLC | 800K | $42.9M | +6.7% | 1.390% | 1.36% |
| 19 | Rock Springs Capital Management LP | 640K | $34.4M | +0.0% | 1.112% | 1.68% |
| 20 | Aberdeen Group plc | 640K | $34.3M | +63.3% | 1.112% | 0.05% |
| 21 | FRANKLIN RESOURCES INC | 579K | $31.1M | +8.9% | 1.006% | 0.01% |
| 22 | BANK OF AMERICA CORP /DE/ | 563K | $30.2M | +148.1% | 0.979% | 0.00% |
| 23 | ALLIANCEBERNSTEIN L.P. | 612K | $29.5M | -4.2% | 1.063% | 0.01% |
| 24 | BlackRock, Inc. | 511K | $27.4M | +15.7% | 0.888% | 0.00% |
| 25 | Logos Global Management LP | 500K | $26.8M | 0.0% | 0.869% | 1.16% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in GPCR — a direct measure of their conviction.
Filings activity in GPCR during Q2 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 194 | 1.0% | 118.28% | +0.70 pp | $3.60B | +14% |
| Q1 2026 | 196 | +0.5% | 117.58% | +1.62 pp | $3.16B | 30% |
| Q4 2025 | 195 | +23% | 115.96% | +14.36 pp | $4.53B | +181% |
| Q3 2025 | 158 | 6.5% | 101.60% | 16.83 pp | $1.61B | +43% |
| Q2 2025 | 169 | +15% | 118.43% | +22.02 pp | $1.13B | +18% |
| Q1 2025 | 147 | 7.0% | 96.41% | 33.31 pp | $952M | 40% |
| Q4 2024 | 158 | +1.3% | 129.72% | +27.57 pp | $1.57B | 36% |
| Q3 2024 | 156 | — | 102.15% | — | $2.44B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying GPCR stock.
Based on Q2 2026 13F filings, institutional ownership of Structure Therapeutics Inc. stands at 118.3%, held across 194 reporting institutions.
FMR LLC is the largest reported institutional holder of GPCR, with approximately 7,810,306 shares worth $0.42B as of Q2 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of GPCR.
Our composite Smart Money Score for GPCR is 39 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
27 institutions opened new positions in GPCR during Q2 2026, while 28 fully exited. 123 added to existing positions and 42 trimmed.
GPCR institutional ownership rose by 0.70 percentage points quarter-over-quarter, with a net change of -2 holders.
The top 10 institutions account for 64.8% of all reported 13F value in GPCR, and the top 25 account for 85.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Structure Therapeutics Inc. (GPCR) Institutional Ownership