Latest Ratios: P/E Ratio 41.2x · EV/EBITDA 35.8x · ROE 18.9%. (2016–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $8.9B | $7.4B | $4.7B | $3.4B | $2.0B | $1.6B | $1.1B | $881M | $233M | $56M | — |
| Enterprise Value | $8.4B | $6.9B | $4.3B | $3.1B | $1.9B | $1.2B | $871M | $696M | $129M | $7M | — |
| P/E Ratio → | 41.21 | 36.04 | 52.22 | 318.10 | — | — | — | — | — | — | — |
| P/S Ratio | 18.87 | 18.98 | 16.04 | 67.91 | — | — | — | — | 226.68 | — | — |
| P/B Ratio | 7.39 | 6.05 | 4.92 | 4.42 | 3.87 | 2.62 | 3.86 | 4.34 | 2.06 | 1.14 | — |
| P/FCF | 28.61 | 39.09 | 39.09 | — | — | — | — | — | — | — | — |
| P/OCF | 44.16 | 36.76 | 37.75 | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 17.72 | 14.88 | 61.00 | — | — | — | — | 125.74 | — | — |
| EV / EBITDA | 35.76 | 41.09 | 59.68 | — | — | — | — | — | — | — | — |
| EV / EBIT | 51.97 | 36.40 | 41.88 | — | — | — | — | — | — | — | — |
| EV / FCF | — | 36.51 | 36.26 | — | — | — | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 92.6% | 92.6% | 93.1% | 93.9% | — | — | — | — | 86.3% | — | — |
| Operating Margin | 41.5% | 41.5% | 22.6% | -216.4% | — | — | — | — | -1160.3% | — | — |
| Net Profit Margin | 52.6% | 52.6% | 30.7% | 21.6% | — | — | — | — | -1060.3% | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | 18.9% | 18.9% | 10.3% | 1.7% | -25.1% | -15.7% | -13.0% | -12.1% | -13.4% | -31.8% | -397.9% |
| ROA | 17.1% | 17.1% | 9.5% | 1.6% | -23.6% | -14.8% | -12.4% | -11.7% | -13.1% | -30.3% | -52.7% |
| ROIC | 18.0% | 18.0% | 9.5% | -20.6% | -34.6% | -34.6% | -91.6% | -117.4% | -189.4% | -7780.4% | — |
| ROCE | 14.8% | 14.8% | 7.6% | -16.7% | -25.7% | -15.2% | -13.2% | -13.8% | -14.6% | -18.5% | -53.4% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | — | — | 6.38 |
| Debt / EBITDA | 0.06 | 0.06 | 0.10 | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.40 | -0.36 | -0.45 | -0.29 | -0.56 | -0.88 | -0.91 | -0.92 | -1.00 | -0.28 |
| Net Debt / EBITDA | -2.90 | -2.90 | -4.66 | — | — | — | — | — | — | — | — |
| Debt / FCF | — | -2.58 | -2.83 | — | — | — | — | — | — | — | — |
| Interest Coverage | — | — | — | — | — | -45.63 | — | — | -10.60 | -1.48 | -163.29 |
Net cash position: cash ($496M) exceeds total debt ($9M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 9.95 | 9.95 | 7.28 | 17.76 | 13.30 | 17.18 | 17.80 | 58.88 | 43.39 | 77.99 | 50.44 |
| Quick Ratio | 9.56 | 9.56 | 7.02 | 17.55 | 13.30 | 17.18 | 17.80 | 58.88 | 43.39 | 77.99 | 50.44 |
| Cash Ratio | 8.04 | 8.04 | 5.86 | 16.08 | 13.14 | 17.02 | 17.56 | 58.22 | 43.05 | 77.49 | 44.72 |
| Asset Turnover | — | 0.29 | 0.28 | 0.06 | — | — | — | — | 0.01 | — | — |
| Inventory Turnover | 0.71 | 0.71 | 0.76 | 0.44 | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | 119.52 | 131.60 | 302.66 | — | — | — | — | — | — | — |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | 2.4% | 2.8% | 1.9% | 0.3% | — | — | — | — | — | — | — |
| FCF Yield | 3.5% | 2.6% | 2.6% | — | — | — | — | — | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — |
| Shares Outstanding | — | $30M | $30M | $28M | $25M | $22M | $19M | $16M | $11M | $5M | $4M |
Includes 30+ ratios · 10 years · Updated daily
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10-year return with dividends reinvested.
Compare growth, multiples, and margins vs sector.
Quick answers to the most common questions about buying KRYS stock.
Krystal Biotech, Inc.'s current P/E ratio is 41.2x. The historical average is 44.1x. This places it at the 50th percentile of its historical range.
Krystal Biotech, Inc.'s current EV/EBITDA is 35.8x. This enterprise value multiple compares the company's total value (equity + debt - cash) to its EBITDA. The historical average is 50.4x.
Krystal Biotech, Inc.'s return on equity (ROE) is 18.9%. The historical average is -47.8%.
Based on historical data, Krystal Biotech, Inc. is trading at a P/E of 41.2x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.
Krystal Biotech, Inc. has 92.6% gross margin and 41.5% operating margin. Operating margin above 20% indicates strong pricing power and cost efficiency.
Krystal Biotech, Inc.'s Debt/EBITDA ratio is 0.1x, indicating low leverage. A ratio below 2x is generally considered financially healthy.
Key Metrics
Top Statement Risk
Single-product revenue concentration
Metrics are mathematically derived from official filings.
Premium Multiples Price in Platform Optionality
Based on reported figures, KRYS trades at 43.90x trailing earnings and 22.75x sales, a premium that suggests investors are capitalizing growth well beyond the current single-product revenue base today.
The forward P/E of 40.98x and forward EV/EBITDA of 28.99x compress only modestly from trailing levels, implying the market expects earnings to rise steadily rather than step-change higher. Against a P/B of 7.37x, the valuation appears to rest on the STAR-D platform's future pipeline value rather than on tangible book assets. Investors should monitor whether revenue growth, now decelerating from 94.9% to 30.2%, can sustain a multiple this elevated.
Operating Margins Expanded Sharply Off a Low Base
According to recent SEC filings, KRYS's operating margin climbed from 12.2% in 2024Q2 to 55.9% in 2026Q3, while gross margin held near 94%, indicating strong operating leverage on incremental revenue overall.
Stable R&D and SG&A spending against rising commercial volume drove most of this expansion, which suggests the cost base is largely fixed rather than scaling with sales. Net margin of 49.5% in the latest quarter, though below the 81.2% spike in 2025Q3, may indicate non-operating items distorted prior periods. Earning power is better reflected by operating margin than by volatile net income.
Returns Remain Thin Despite Expanding Margins
Based on KRYS's reported figures, ROIC of 5.6% and ROE of 4.5% in 2026Q3 remain low relative to the company's margin profile, reflecting a large equity base built largely from retained cash.
ROIC has only drifted from 1.4% to 5.6% over ten quarters, meaning the rapid rise in operating margin has not yet translated into proportionate capital efficiency. The growing asset base of roughly $1.6B, much of it idle cash, appears to dilute returns. This suggests the return profile will depend on whether management deploys the cash productively.
Working Capital Cycle Stretched by Payables
As reported in financial statements, KRYS's cash conversion cycle of 604 days in 2026Q3 is driven largely by inventory days near 587 and payables near 81, a structure that warrants scrutiny going forward.
Days inventory outstanding far exceeds receivable collection of roughly 98 days, which may reflect the specialized biologic production cycle rather than operational slack. Asset turnover of 0.08x confirms the asset base is heavy relative to revenue, consistent with cash accumulation. Investors should watch whether the inventory build reflects prudent supply planning or slowing demand.
Liquidity Position Exceeds Any Plausible Stress
According to reported figures, KRYS's current ratio of 7.89 and quick ratio of 7.53 in 2026Q3 indicate liquidity far exceeds short-term obligations, providing a substantial buffer under severe stress scenarios.
Near-identical current and quick ratios show that inventory contributes little to the liquidity cushion, so the position rests on cash rather than inventory conversion. Total debt of roughly $8.6M against a debt-to-EBITDA of 0.12x suggests no meaningful refinancing pressure. The primary liquidity question is deployment, not solvency.
Single-Product Dependence Could Cap Multiples
Based on reported figures, KRYS's revenue rests entirely on VYJUVEK, and growth slowing to 30.2% from 94.9% may suggest the initial patient backlog is narrowing faster than pipeline revenue can replace it.
If the current 43.90x trailing P/E assumes sustained high growth, a continued deceleration could compress the multiple even if margins hold near current levels. The ratio most often misapplied here is price-to-book, since KRYS's 7.37x P/B largely reflects accumulated cash rather than productive operating assets, making it a weak anchor for value. Free cash flow yield on sustainable maintenance revenue would be a more informative alternative measure.