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MNPRMonopar Therapeutics Inc.
$67.47$452M
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MNPR logoMonopar Therapeutics Inc.(MNPR)Earnings, Financials & Key Ratios

MNPR•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutMonopar Therapeutics Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutics for the treatment of cancer in the United States. Its lead product candidate in development is Validive, a clonidine hydrochloride mucobuccal tablet that is in Phase 2b/3 clinical trial for the prevention of chemoradiotherapy induced severe oral mucositis in patients with oropharyngeal cancer. The company also engages in developing Camsirubicin, an analog of doxorubicin, which is in Phase 1b clinical trial for the treatment of advanced soft tissue sarcoma; MNPR-101, a urokinase plasminogen activator receptor targeted antibody for the treatment of various cancers; MNPR-101 RIT, a radioimmunotherapeutic based on MNPR-101 for the potential treatment of cancer and severe COVID-19; and MNPR-202, an analog of camsirubicin to potentially treat doxorubicin-and camsirubicin-resistant cancers. Monopar Therapeutics Inc. has collaborations with the Grupo Español de Investigación en Sarcomas for the development of camsirubicin in patients with advanced soft tissue sarcoma; NorthStar Medical Radioisotopes, LLC to develop radio-immuno-therapeutics targeting severe COVID-19; and the Cancer Science Institute of Singapore to evaluate the activity of MNPR-202 and related analogs in various types of cancer. The company was incorporated in 2014 and is headquartered in Wilmette, Illinois.Show more
  • Revenue$0
  • EBITDA-$17M-3.4%
  • Net Income-$14M+12.0%
  • EPS (Diluted)-1.85-36.0%
  • ROE-14.22%+72.3%

MNPR Key Insights

Monopar Therapeutics Inc. (MNPR) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Share count reduced 35.5% through buybacks

✗Weaknesses

  • ✗Profits declining 16.8% over 5 years
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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MNPR Price & Volume

Monopar Therapeutics Inc. (MNPR) stock price & volume — 10-year historical chart

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MNPR Growth Metrics

Monopar Therapeutics Inc. (MNPR) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM9.57%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-30.19%

Return on Capital

10 Years-74.93%
5 Years-61.7%
3 Years-61.08%
Last Year-17.31%

MNPR Recent Earnings

Monopar Therapeutics Inc. (MNPR) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)
Q2 2026Latest
May 14, 2026
Metric
Actual
Est
EPS
$0.46+56.6%
$1.06
Rev
—
—
Q2 2026
Mar 27, 2026
Metric
Actual
Est
EPS
$0.61-19.1%
$0.51
Rev
—
—
Q4 2025
Nov 13, 2025
Metric
Actual
Est
EPS
$0.48-4.3%
$0.46
Rev
—
—
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.35+25.5%
$0.47
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 14, 2026
$0.46vs $1.06+56.6%
—
Q2 2026Mar 27, 2026
$0.61vs $0.51-19.1%
—
Q4 2025Nov 13, 2025
$0.48vs $0.46-4.3%
—
Q3 2025Aug 12, 2025
$0.35vs $0.47+25.5%
—
Based on last 12 quarters of dataView full earnings history →

MNPR Peer Comparison

Monopar Therapeutics Inc. (MNPR) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
CLDX logoCLDXCelldex Therapeutics, Inc.Direct Competitor2.16B32.43-8.32-78.63%-345.96%-50.72%0.00
IMVT logoIMVTImmunovant, Inc.Direct Competitor7.26B35.34-12.76-68.16%0.00
TPVG logoTPVGTriplePoint Venture Growth BDC Corp.Direct Competitor202.99M5.004.1036.55%-19.55%-3.39%1.33
NKTR logoNKTRNektar TherapeuticsDirect Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
ADXN logoADXNAddex Therapeutics LtdDirect Competitor4.47M6.20-0.72-92.58%-101.41%-102.59%0.01
CASI logoCASICASI Pharmaceuticals, Inc.Product Competitor2.33M0.15-0.06-15.77%-183.93%-301.8%11.96
AGEN logoAGENAgenus Inc.Product Competitor124.93M3.00-882.3510.37%52.16%
SNDX logoSNDXSyndax Pharmaceuticals, Inc.Product Competitor1.68B19.00-5.786.28%-112.01%-256.66%5.36

Compare MNPR vs Peers

Monopar Therapeutics Inc. (MNPR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CLDX

Most directly comparable listed peer for MNPR.

Scale Benchmark

vs RVMD

Larger-name benchmark to compare MNPR against a more recognizable public peer.

Peer Set

Compare Top 5

vs CLDX, IMVT, TPVG, NKTR

MNPR Income Statement

Monopar Therapeutics Inc. (MNPR) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
0000000000
Revenue Growth %
----------
Cost of Goods Sold
0000000000
COGS % of Revenue
----------
Gross Profit
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
Gross Margin %
----------
Gross Profit Growth %
----------
Operating Expenses
16.6M3.4M4.32M6.51M9.13M10.54M8.83M16.16M16.7M18.71M
OpEx % of Revenue
----------
Selling, General & Admin
1.17M1.63M2.36M2.44M2.63M2.95M3.23M3.16M6.8B1.74B
SG&A % of Revenue
----------
Research & Development
935.32K1.77M1.97M4.07M6.49M7.59M5.6M13.01M9.9B11.75M
R&D % of Revenue
----------
Other Operating Expenses
14.5M0000000-16.69B-1M
Operating Income
-16.6M▲ 0%
-3.4M▲ 79.5%
-4.32M▼ 27.1%
-6.51M▼ 50.5%
-9.13M▼ 40.2%
-10.54M▼ 15.4%
-8.83M▲ 16.2%
-16.16M▼ 83.0%
-16.7M▼ 3.4%
-18.71M▲ 0%
Operating Margin %
----------
Operating Income Growth %
-1291.9%79.5%-27.06%-50.54%-40.23%-15.44%16.19%-83.01%-3.36%-
EBITDA
-14.5M-72K-4.22M0-9.13M-10.54M-8.83M-16.16M-16.7M-17.93M
EBITDA Margin %
----------
EBITDA Growth %
-99.5%-5767.88%100%--15.44%16.19%-83.01%-3.36%-3.98%
D&A (Non-Cash Add-back)
2.1M3.33M06.51M000000
EBIT
-16.55M-3.33M-4.22M-6.51M-9.13M-10.54M-8.83M-16.16M-16.7M-17.93M
Net Interest Income
0098.89K81.9K24.02K21.24K429.04K404.02K2.99M3.72M
Interest Income
48.26K103.22K98.89K81.9K24.02K21.24K429.04K404.02K2.99M3.72M
Interest Expense
48.26K103.22K00000000
Other Income/Expense
48.26K31.15K98.89K204.3K24.02K21.24K429.04K575.3K2.99M3.72M
Pretax Income
-16.55M▲ 0%
-3.3M▲ 80.1%
-4.22M▼ 28.0%
-6.3M▼ 49.2%
-9.1M▼ 44.4%
-10.52M▼ 15.5%
-8.4M▲ 20.1%
-15.59M▼ 85.5%
-13.72M▲ 12.0%
-14.98M▲ 0%
Pretax Margin %
----------
Income Tax
0-71.61K00000000
Effective Tax Rate %
0%2.17%0%0%0%0%0%0%0%0%
Net Income
-16.55M▲ 0%
-3.23M▲ 80.5%
-4.22M▼ 30.9%
-6.3M▼ 49.2%
-9.1M▼ 44.4%
-10.52M▼ 15.5%
-8.4M▲ 20.1%
-15.59M▼ 85.5%
-13.72M▲ 12.0%
-14.98M▲ 0%
Net Margin %
----------
Net Income Growth %
-1296.34%80.5%-30.88%-49.23%-44.39%-15.52%20.1%-85.5%11.99%9.57%
Net Income (Continuing)
-16.55M-3.23M-4.22M-6.3M-9.1M-10.52M-8.4M-15.59M-13.72M-14.98M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.59▲ 0%
-0.31▲ 80.5%
-0.40▼ 29.0%
-0.58▼ 45.0%
-0.73▼ 25.9%
-0.83▼ 13.7%
-0.58▲ 30.1%
-1.36▼ 134.5%
-1.85▼ 36.0%
-1.76▲ 0%
EPS Growth %
-1225%80.5%-29.03%-45%-25.86%-13.7%30.12%-134.48%-36.03%-30.19%
EPS (Basic)
-1.59-0.31-0.40-0.58-0.73-0.83-0.58-1.36-1.85-
Diluted Shares Outstanding
10.42M10.42M10.59M10.96M12.47M12.72M14.51M11.48M7.41M8.54M
Basic Shares Outstanding
10.42M10.42M10.59M10.96M12.47M12.72M14.51M11.44M7.41M8.54M
Dividend Payout Ratio
----------

MNPR Balance Sheet

Monopar Therapeutics Inc. (MNPR) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
9.13M7.32M13.23M16.8M20.52M13.17M7.33M60.29M140.46M137.74M
Cash & Short-Term Investments
8.98M6.89M13.21M16.74M20.3M13.12M7.27M60.21M140.4M137.49M
Cash Only
8.98M6.89M13.21M16.74M20.3M8.19M7.27M45.82M61.83M52.54M
Short-Term Investments
000004.93M014.4M78.57M84.95M
Accounts Receivable
0000000000
Days Sales Outstanding
----------
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
0015.71K62.69K217.75K45.98K66.43K78.87K63.74K250.9K
Total Non-Current Assets
800.03K410.67K122.38K68.86K061.23K12.65K0254.92K239.88K
Property, Plant & Equipment
0000061.23K12.65K0254.92K239.88K
Fixed Asset Turnover
---------0.00x
Goodwill
0000000000
Intangible Assets
730.65M000000000
Long-Term Investments
0000000000
Other Non-Current Assets
-729.85M410.67K122.38K68.86K000000
Total Assets
9.93M▲ 0%
7.32M▼ 26.3%
13.35M▲ 82.5%
16.87M▲ 26.3%
20.52M▲ 21.7%
13.23M▼ 35.5%
7.35M▼ 44.5%
60.29M▲ 720.8%
140.72M▲ 133.4%
137.98M▲ 0%
Asset Turnover
---------0.00x
Asset Growth %
242.98%-26.31%82.46%26.34%21.66%-35.55%-44.47%720.83%133.4%3209.84%
Total Current Liabilities
311.87K399.55K724.16K1.18M1.58M3.13M1.76M5.25M2.74M2.46M
Accounts Payable
311.87K399.55K724.16K1.18M1.58M3.13M1.76M2.25M2.74M2.46M
Days Payables Outstanding
----------
Short-Term Debt
0000000000
Deferred Revenue (Current)
0000000000
Other Current Liabilities
0000000000
Current Ratio
29.28x18.32x18.27x14.28x12.98x4.21x4.17x11.47x51.35x56.04x
Quick Ratio
29.28x18.32x18.27x14.28x12.98x4.21x4.17x11.47x51.35x56.04x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
000008.41K00154.92K131.56K
Long-Term Debt
0000000000
Capital Lease Obligations
000008.41K00154.92K437.73K
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
0000000000
Total Liabilities
311.87K399.55K724.16K1.18M1.58M3.14M1.76M5.25M2.89M2.59M
Total Debt
000008.41K00154.92K131.56K
Net Debt
-8.98M-6.89M-13.21M-16.74M-20.3M-8.18M-7.27M-45.82M-61.68M-52.41M
Debt / Equity
-----0.00x--0.00x0.00x
Debt / EBITDA
----------0.01x
Net Debt / EBITDA
---------2.92x
Interest Coverage
-343.07x-32.27x--------
Total Equity
9.62M▲ 0%
6.92M▼ 28.1%
12.63M▲ 82.5%
15.69M▲ 24.3%
18.94M▲ 20.7%
10.09M▼ 46.7%
5.59M▼ 44.6%
55.04M▲ 885.0%
137.83M▲ 150.4%
135.39M▲ 0%
Equity Growth %
239.78%-28.08%82.53%24.26%20.71%-46.73%-44.62%884.95%150.43%3821.78%
Book Value per Share
0.920.661.191.431.520.790.394.7918.6015.86
Total Shareholders' Equity
9.62M6.92M12.63M15.69M18.94M10.09M5.59M55.04M137.83M135.39M
Common Stock
9.29K9.29K10.59K11.45K12.6K12.95K14.9K6.1K6.69K6.7K
Retained Earnings
-18.43M-21.66M-25.88M-32.19M-41.29M-51.8M-60.21M-75.79M-89.51M-93.4M
Treasury Stock
0000000000
Accumulated OCI
0-2.4K-10.97K-7.87K-3.16K8.94K-14.13K35.99K131.39K98.52K
Minority Interest
0000000000

MNPR Cash Flow Statement

Monopar Therapeutics Inc. (MNPR) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-2.63M-2.89M-3.02M-4.66M-7.32M-7.23M-7.86M-6.4M-12.2M-10.01M
Operating CF Margin %
----------
Operating CF Growth %
-119.94%-9.87%-4.54%-54.5%-56.95%1.21%-8.71%18.5%-90.52%-88.97%
Net Income
-16.55M-3.23M-4.22M-6.3M-9.1M-10.52M-8.4M-15.59M-13.72M-14.98M
Depreciation & Amortization
0000000000
Stock-Based Compensation
305.2K529.33K1.01M1.32M1.47M1.64M1.9M1.14M02.38M
Deferred Taxes
0000000000
Other Non-Cash Items
13.5M441.65K0-122.4K0004.55M4.12M1.28M
Working Capital Changes
120.58K-188.16K196.02K443.81K317.77K1.65M-1.35M3.49M-2.61M1.31M
Change in Receivables
0000000000
Change in Inventory
0000000000
Change in Payables
247.36K87.68K243.53K447.6K403.97K1.48M-1.33M506.79K388.22K872.05K
Cash from Investing
00000-4.92M4.93M-14.34M-63.45M-68.71M
Capital Expenditures
0000000000
CapEx % of Revenue
----------
Acquisitions
0000000000
Investments
----------
Other Investing
0000000000
Cash from Financing
9.54M-206.27K9.35M8.18M10.88M32.87K2.03M59.29M91.57M91.49M
Debt Issued (Net)
000122.4K000000
Equity Issued (Net)
4.71M010.22M8.18M10.93M109.34K2.07M59.4M92.71M92.69M
Dividends Paid
0000000000
Share Repurchases
00000000-35M-35M
Other Financing
4.83M-206.27K-874.81K-115.57K-45.77K-76.46K-46.97K-104.14K-1.13M-1.2M
Net Change in Cash
6.91M▲ 0%
-2.89M▼ 141.8%
6.32M▲ 318.8%
3.52M▼ 44.3%
3.57M▲ 1.2%
-12.12M▼ 439.7%
-920.11K▲ 92.4%
38.55M▲ 4289.7%
16.02M▼ 58.5%
12.83M▲ 0%
Free Cash Flow
-2.63M▲ 0%
-2.89M▼ 9.9%
-3.02M▼ 4.5%
-4.66M▼ 54.5%
-7.32M▼ 56.9%
-7.23M▲ 1.2%
-7.86M▼ 8.7%
-6.4M▲ 18.5%
-12.2M▼ 90.5%
-10.01M▲ 0%
FCF Margin %
----------
FCF Growth %
-119.94%-9.87%-4.54%-54.5%-56.95%1.21%-8.71%18.5%-90.52%3.84%
FCF per Share
-0.25-0.28-0.29-0.43-0.59-0.57-0.54-0.56-1.65-1.17
FCF Conversion (FCF/Net Income)
0.16x0.89x0.71x0.74x0.80x0.69x0.94x0.41x0.89x0.67x
Interest Paid
0000000000
Taxes Paid
0000000000

MNPR Key Ratios

Monopar Therapeutics Inc. (MNPR) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-265.93%-39.04%-43.23%-44.52%-52.57%-72.44%-107.19%-51.42%-14.22%-12.84%
Return on Invested Capital (ROIC)
-1784.05%-769.75%----2878.57%-5671.91%-321.43%-29.35%-30.19%
Debt / Equity
-----0.00x--0.00x0.00x
Interest Coverage
-343.07x-32.27x--------
FCF Conversion
0.16x0.89x0.71x0.74x0.80x0.69x0.94x0.41x0.89x0.67x
Related:MNPR Dividend History·MNPR Revenue History·MNPR Price History·MNPR P/E History·MNPR Financial Ratios·MNPR Institutional Holders

MNPR SEC Filings & Documents

Monopar Therapeutics Inc. (MNPR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 19, 2026·SEC

Material company update

May 14, 2026·SEC

Material company update

Apr 20, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 27, 2026·SEC

FY 2025

Mar 31, 2025·SEC

FY 2024

Mar 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 14, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 12, 2025·SEC

MNPR Frequently Asked Questions

Monopar Therapeutics Inc. (MNPR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Monopar Therapeutics Inc. (MNPR) grew revenue by 0.0% over the past year. Growth has been modest.

Monopar Therapeutics Inc. (MNPR) reported a net loss of $15.0M for fiscal year 2025.

Dividend & Returns

Monopar Therapeutics Inc. (MNPR) has a return on equity (ROE) of -14.2%. Negative ROE indicates the company is unprofitable.

Monopar Therapeutics Inc. (MNPR) had negative free cash flow of $10.0M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in MNPR back in 2015?

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