Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in PRME held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Alphabet Inc. | 16.6M | $57.6M | 0.0% | 9.170% | 1.44% |
| 2 | BlackRock, Inc. | 8.5M | $29.6M | +2.8% | 4.707% | 0.00% |
| 3 | STATE STREET CORP | 6.3M | $22.1M | +24.5% | 3.513% | 0.00% |
| 4 | ARK Investment Management LLC | 6.2M | $21.7M | +16.4% | 3.459% | 0.17% |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 4.5M | $15.6M | β | 2.477% | 0.00% |
| 6 | BALYASNY ASSET MANAGEMENT LLC | 4.1M | $14.3M | +32.0% | 2.283% | 0.05% |
| 7 | Casdin Capital, LLC | 3.2M | $11.0M | 0.0% | 1.753% | 0.83% |
| 8 | Woodline Partners LP | 3.0M | $10.5M | +0.0% | 1.663% | 0.04% |
| 9 | Sumitomo Mitsui Trust Holdings, Inc. | 2.9M | $10.2M | -9.4% | 1.628% | 0.01% |
| 10 | Nikko Asset Management Americas, Inc. | 2.9M | $10.2M | -9.4% | 1.628% | 0.14% |
| 11 | UBS Group AG | 2.9M | $10.1M | +18.4% | 1.599% | 0.00% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 2.7M | $9.6M | +4.4% | 1.519% | 0.00% |
| 13 | ADAR1 Capital Management, LLC | 2.0M | $6.9M | β | 1.093% | 0.43% |
| 14 | FMR LLC | 1.8M | $6.2M | -18.7% | 0.980% | 0.00% |
| 15 | Redmile Group, LLC | 1.6M | $5.5M | β | 0.881% | 0.37% |
| 16 | TWO SIGMA INVESTMENTS, LP | 1.6M | $5.5M | -3.5% | 0.871% | 0.00% |
| 17 | D. E. Shaw & Co., Inc. | 1.4M | $4.8M | -10.2% | 0.772% | 0.00% |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.3M | $4.7M | -21.2% | 0.747% | 0.00% |
| 19 | FARALLON CAPITAL MANAGEMENT LLC | 1.2M | $4.3M | 0.0% | 0.687% | 0.03% |
| 20 | GOLDMAN SACHS GROUP INC | 970K | $3.4M | -44.7% | 0.537% | 0.00% |
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 917K | $3.2M | -2.1% | 0.508% | 0.00% |
| 22 | NORTHERN TRUST CORP | 887K | $3.1M | +5.3% | 0.491% | 0.00% |
| 23 | VANGUARD PORTFOLIO MANAGEMENT LLC | 862K | $3.0M | β | 0.477% | 0.00% |
| 24 | RENAISSANCE TECHNOLOGIES LLC | 741K | $2.6M | -35.5% | 0.410% | 0.00% |
| 25 | VANGUARD FIDUCIARY TRUST CO | 717K | $2.5M | β | 0.397% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in PRME β a direct measure of their conviction.
Filings activity in PRME during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new PRME position in Q1 2026
Institutions that fully closed their PRME position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 187 | +3.9% | 62.95% | +1.13 pp | $316M | +1.8% |
| Q4 2025 | 180 | +13% | 61.82% | 30.16 pp | $310M | 33% |
| Q3 2025 | 160 | +32% | 91.98% | +66.89 pp | $461M | +267% |
| Q2 2025 | 121 | 1.6% | 25.09% | +3.92 pp | $126M | +19% |
| Q1 2025 | 123 | 5.4% | 21.17% | 12.28 pp | $106M | 37% |
| Q4 2024 | 130 | +13% | 33.45% | 14.65 pp | $168M | 30% |
| Q3 2024 | 115 | 4.2% | 48.10% | 15.92 pp | $241M | 25% |
| Q2 2024 | 120 | β | 64.02% | β | $321M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying PRME stock.
Based on Q1 2026 13F filings, institutional ownership of Prime Medicine, Inc. stands at 62.9%, held across 187 reporting institutions.
Alphabet Inc. is the largest reported institutional holder of PRME, with approximately 16,562,498 shares worth $0.06B as of Q1 2026.
Yes β 4 widely-followed marquee investors appear among the top 25 institutional holders of PRME, including ARK Investment Management LLC, TWO SIGMA INVESTMENTS, LP, SUSQUEHANNA INTERNATIONAL GROUP, LLP, RENAISSANCE TECHNOLOGIES LLC.
Our composite Smart Money Score for PRME is 72 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
39 institutions opened new positions in PRME during Q1 2026, while 32 fully exited. 94 added to existing positions and 49 trimmed.
PRME institutional ownership rose by 1.13 percentage points quarter-over-quarter, with a net change of +7 holders.
The top 10 institutions account for 64.3% of all reported 13F value in PRME, and the top 25 account for 88.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Prime Medicine, Inc. (PRME) Institutional Ownership