Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in PTGX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BlackRock, Inc. | 9.8M | $1.03B | +0.7% | 15.206% | 0.02% |
| 2 | FARALLON CAPITAL MANAGEMENT LLC | 6.3M | $669.2M | +3.3% | 9.872% | 4.36% |
| 3 | UBS Group AG | 5.2M | $545.7M | +86.9% | 8.051% | 0.08% |
| 4 | RTW INVESTMENTS, LP | 5.1M | $533.2M | 0.0% | 7.867% | 5.31% |
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 3.6M | $379.4M | +13.5% | 5.597% | 0.07% |
| 6 | STATE STREET CORP | 3.1M | $328.5M | -2.6% | 4.846% | 0.01% |
| 7 | JANUS HENDERSON GROUP PLC | 2.9M | $304.9M | +9.1% | 4.496% | 0.15% |
| 8 | JOHNSON & JOHNSON | 2.4M | $258.1M | 0.0% | 3.808% | 39.57% |
| 9 | Invesco Ltd. | 2.2M | $228.2M | +38.1% | 3.366% | 0.03% |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 1.7M | $176.0M | +14.9% | 2.596% | 0.01% |
| 11 | CITADEL ADVISORS LLC | 1.6M | $169.1M | +31.3% | 2.495% | 0.08% |
| 12 | Woodline Partners LP | 1.4M | $149.1M | +0.4% | 2.199% | 0.56% |
| 13 | BANK OF AMERICA CORP /DE/ | 1.3M | $136.5M | +49.3% | 2.014% | 0.01% |
| 14 | PERCEPTIVE ADVISORS LLC | 1.2M | $129.7M | -8.8% | 1.914% | 2.57% |
| 15 | JENNISON ASSOCIATES LLC | 1.1M | $113.0M | +223.7% | 1.667% | 0.08% |
| 16 | MORGAN STANLEY | 1.0M | $107.3M | +15.8% | 1.583% | 0.01% |
| 17 | ADAR1 Capital Management, LLC | 994K | $104.8M | -5.3% | 1.546% | 6.55% |
| 18 | Hood River Capital Management LLC | 829K | $87.4M | — | 1.290% | 0.88% |
| 19 | GOLDMAN SACHS GROUP INC | 779K | $82.1M | -19.0% | 1.211% | 0.01% |
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 721K | $76.0M | -34.4% | 1.121% | 0.56% |
| 21 | FMR LLC | 662K | $69.8M | +22.6% | 1.029% | 0.00% |
| 22 | MARSHALL WACE, LLP | 628K | $66.2M | -38.7% | 0.977% | 0.07% |
| 23 | Clearbridge Investments, LLC | 622K | $65.5M | +26.9% | 0.967% | 0.06% |
| 24 | Alyeska Investment Group, L.P. | 593K | $62.5M | +197.3% | 0.922% | 0.18% |
| 25 | NORTHERN TRUST CORP | 588K | $62.0M | +2.2% | 0.914% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in PTGX — a direct measure of their conviction.
Filings activity in PTGX during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 304 | 2.3% | 103.63% | +18.15 pp | $7.32B | +21% |
| Q4 2025 | 311 | +15% | 85.48% | +21.06 pp | $6.03B | +33% |
| Q3 2025 | 270 | 0.4% | 64.42% | +10.17 pp | $4.55B | +19% |
| Q2 2025 | 271 | +2.7% | 54.25% | +11.26 pp | $3.83B | +26% |
| Q1 2025 | 264 | +11% | 42.99% | +9.52 pp | $3.03B | +28% |
| Q4 2024 | 238 | +1.7% | 33.47% | 4.28 pp | $2.36B | 11% |
| Q3 2024 | 234 | +26% | 37.75% | +9.48 pp | $2.67B | +34% |
| Q2 2024 | 186 | — | 28.27% | — | $2.00B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying PTGX stock.
Based on Q1 2026 13F filings, institutional ownership of Protagonist Therapeutics, Inc. stands at 103.6%, held across 304 reporting institutions.
BlackRock, Inc. is the largest reported institutional holder of PTGX, with approximately 9,779,369 shares worth $1.03B as of Q1 2026.
Yes — 1 widely-followed marquee investor appear among the top 25 institutional holders of PTGX, including CITADEL ADVISORS LLC.
Our composite Smart Money Score for PTGX is 54 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
51 institutions opened new positions in PTGX during Q1 2026, while 58 fully exited. 210 added to existing positions and 41 trimmed.
PTGX institutional ownership rose by 18.15 percentage points quarter-over-quarter, with a net change of -7 holders.
The top 10 institutions account for 60.9% of all reported 13F value in PTGX, and the top 25 account for 81.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Protagonist Therapeutics, Inc. (PTGX) Institutional Ownership