| 4 | VANGUARD PORTFOLIO MANAGEMENT LLC | 3.6M | $444.9M | +4.3% | 5.643% | 0.02% |
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 3.4M | $418.8M | -5.1% | 5.313% | 0.07% |
| 6 | UBS Group AG | 3.4M | $416.7M | -34.4% | 5.286% | 0.05% |
| 7 | STATE STREET CORP | 3.3M | $407.2M | +6.6% | 5.165% | 0.01% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2.9M | $349.8M | +1.7% | 4.437% | 0.01% |
| 9 | JOHNSON & JOHNSON | 2.4M | $300.2M | 0.0% | 3.808% | 37.59% |
| 10 | Invesco Ltd. | 2.3M | $286.9M | +8.1% | 3.640% | 0.02% |
| 11 | Jupiter Topco LLC | 2.1M | $261.0M | — | 3.312% | 0.11% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 1.7M | $213.5M | +4.3% | 2.708% | 0.01% |
| 13 | Woodline Partners LP | 1.4M | $173.3M | 0.0% | 2.199% | 0.54% |
| 14 | BANK OF AMERICA CORP /DE/ | 1.3M | $162.4M | +2.2% | 2.059% | 0.01% |
| 15 | JENNISON ASSOCIATES LLC | 1.2M | $141.2M | +7.4% | 1.791% | 0.08% |
| 16 | PERCEPTIVE ADVISORS LLC | 982K | $120.4M | -20.2% | 1.527% | 1.81% |
| 17 | ADAR1 Capital Management, LLC | 961K | $117.8M | -3.4% | 1.494% | 5.39% |
| 18 | MORGAN STANLEY | 906K | $111.1M | -11.0% | 1.409% | 0.01% |
| 19 | Alyeska Investment Group, L.P. | 889K | $109.0M | +49.9% | 1.383% | 0.28% |
| 20 | Hood River Capital Management LLC | 883K | $108.2M | +6.5% | 1.373% | 0.78% |
| 21 | GOLDMAN SACHS GROUP INC | 813K | $99.6M | +4.3% | 1.264% | 0.01% |
| 22 | DRIEHAUS CAPITAL MANAGEMENT LLC | 731K | $89.6M | +1.4% | 1.137% | 0.52% |
| 23 | Clearbridge Investments, LLC | 725K | $88.9M | +16.7% | 1.128% | 0.07% |
| 24 | FMR LLC | 672K | $82.4M | +1.5% | 1.045% | 0.00% |
| 25 | NORTHERN TRUST CORP | 666K | $81.7M | +13.3% | 1.036% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in PTGX — a direct measure of their conviction.
| 106.29% |
| +2.12 pp |
| $3.03B |
| +28% |
| Q4 2024 | 238 | +1.7% | 104.17% | +0.50 pp | $2.36B | 11% |
| Q3 2024 | 234 | — | 103.67% | — | $2.67B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
56 institutions opened new positions in PTGX during Q2 2026, while 33 fully exited. 241 added to existing positions and 39 trimmed.
PTGX institutional ownership fell by 5.00 percentage points quarter-over-quarter, with a net change of +27 holders.
The top 10 institutions account for 58.8% of all reported 13F value in PTGX, and the top 25 account for 80.7%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Protagonist Therapeutics, Inc. (PTGX) Institutional Ownership