Protagonist Therapeutics, Inc. (PTGX) Revenue History
Annual and quarterly revenue from 2014 to present
PTGX Revenue Over Time (2014–2025)
PTGX Revenue Growth History
4 of 8 years with positive growth- FY2014 revenue growth
- N/A
- FY2015 revenue growth
- N/A
- FY2016 revenue growth
- N/A
- FY2017 revenue growth
- N/A
- FY2018 revenue growth
- +54.1%
- FY2019 revenue growth
- -99.3%
- FY2020 revenue growth
- +12293.1%
- FY2021 revenue growth
- -4.4%
- FY2022 revenue growth
- -2.8%
- FY2023 revenue growth
- +125.7%
- FY2024 revenue growth
- +624.1%
- FY2025 revenue growth
- -89.4%
| Quarter | Revenue | YoY |
|---|---|---|
| Q1 2026 | $0 | -100.0% |
| Q4 2025 | $7.4M | -95.6% |
| Q3 2025 | $4.7M | +0.8% |
| Q2 2025 | $5.5M | +33.1% |
| Q1 2025 | $28.3M | -88.9% |
| Q4 2024 | $170.6M | +184.4% |
| Q3 2024 | $4.7M | — |
| Q2 2024 | $4.2M | — |
Multi-year avg. share of annual revenue by fiscal quarter
Revenue Breakdown (FY 2024)
PTGX's revenue distribution by segment and geography for fiscal year 2024
By Product/Segment
PTGX Revenue Analysis (2014–2025)
Current Revenue & Growth
As of June 22, 2026, Protagonist Therapeutics, Inc. (PTGX) generated trailing twelve-month (TTM) revenue of $17.7 million, reflecting significant decline in growth of -100.0% year-over-year. The most recent quarter (Q1 2026) recorded $0 in revenue, down 100.0% sequentially.
Historical Growth Trajectory
PTGX's 5-year compound annual growth rate (CAGR) stands at +10.0%, indicating steady revenue expansion. The 3-year CAGR of +20.1% exceeds the 5-year average, indicating an acceleration in the most recent period. Protagonist Therapeutics, Inc.'s highest annual revenue of $434.4 million was recorded in 2024.
Revenue by Segment
PTGX's revenue is primarily driven by Development Services (100%). With over half of revenue concentrated in Development Services, the company has a focused business model while developing other growth vectors.
Peer Comparison
Compared to Healthcare sector peers — including KYMR (-12.6% YoY), PRTA (-58.0% YoY), and ACRS (-52.9% YoY) — PTGX has underperformed the peer group in revenue growth. Compare PTGX vs KYMR →
PTGX Revenue vs Peers
Revenue metrics vs comparable public companies
| Company | TTM Revenue | YoY Growth | 5Y CAGR | Op. Margin | Compare |
|---|---|---|---|---|---|
| PTGXCurrent | $18M | -100.0% | +10.0% | -343.6% | |
 KYMR | $39M | -12.6% | +2.9% | -891.3% | |
 PRTA | $10M | -58.0% | +62.6% | -1905.8% | |
 ACRS | $8M | -52.9% | +3.8% | -975.9% | |
 ARDX | $407M | +18.2% | +121.9% | -10.1% |
PTGX Historical Revenue Data (2014–2025)
| Year | Revenue | YoY % | Gross Profit | Gross Margin | Op. Income | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | $46.0M | -89.4% | $44.8M | 97.3% | $-158,127,000 | -343.6% |
| 2024 | $434.4M | +624.1% | $434.4M | 100.0% | $252.8M | 58.2% |
| 2023 | $60.0M | +125.7% | $60.0M | 100.0% | $-93,652,000 | -156.1% |
| 2022 | $26.6M | -2.8% | $26.6M | 100.0% | $-131,373,000 | -494.2% |
| 2021 | $27.4M | -4.4% | $27.4M | 100.0% | $-125,845,000 | -460.0% |
| 2020 | $28.6M | +12293.1% | $28.6M | 100.0% | $-64,516,000 | -225.4% |
| 2019 | $231K | -99.3% | $231K | 100.0% | $-80,521,000 | -34857.6% |
| 2018 | $30.9M | +54.1% | $30.9M | 100.0% | $-42,269,000 | -136.7% |
| 2017 | $20.1M | - | $20.1M | 100.0% | $-37,897,000 | -188.9% |
| 2016 | $0 | - | $-317,000 | - | $-32,666,000 | - |
| 2015 | $0 | - | $-247,000 | - | $-14,794,000 | - |
| 2014 | $0 | - | $0 | - | $-9,319,000 | - |
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
12+ years return with dividends reinvested.
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Peer Comparison
Compare growth, multiples, and margins vs sector.
PTGX — Frequently Asked Questions
Quick answers to the most common questions about buying PTGX stock.
Is PTGX's revenue growth accelerating or slowing?
PTGX revenue is declining -100.0% year-over-year. TTM revenue fell to $18M, contrasting with the 5-year CAGR of +10.0%. The reversal reflects either macro headwinds or company-specific challenges.
What is PTGX's revenue history from 2014 to 2026?
Protagonist Therapeutics, Inc. (PTGX) revenue history spans 2014 to 2026. TTM revenue as of 2026 is $18M, growing at -100.0% YoY. The 5-year CAGR is +10.0%. Complete annual and quarterly revenue figures are available on this page, including gross profit, operating income, and margin trends.
What is PTGX's long-term revenue growth rate (CAGR)?
Protagonist Therapeutics, Inc.'s 5-year revenue CAGR of +10.0% reflects the variable nature of its business expansion. As of 2026, the current YoY growth rate of -100.0% is below this long-term average. CAGR is the most reliable measure of sustained revenue momentum for PTGX.
Why does PTGX's quarterly revenue fluctuate?
PTGX quarterly revenue can fluctuate significantly between periods. A quarter-over-quarter (QoQ) change does not always indicate a trend; comparing the same quarter year-over-year (YoY) is a more reliable signal for underlying growth. Protagonist Therapeutics, Inc.'s revenue data from 2014 to 2026 shows full historical quarterly detail on this page.
How is PTGX's revenue distributed by segment?
PTGX reports revenue broken down by product line and geographic region. The segment breakdown on this page shows which business units contribute the most to total revenue as of the latest fiscal year. Concentration in a single segment above 50% indicates category dependence, while a diversified mix signals more resilient revenue streams.
How does PTGX's revenue compare to industry peers?
Protagonist Therapeutics, Inc. (PTGX) with TTM revenue of $18M and -100.0% YoY growth can be benchmarked against sector peers using the comparison table on this page. Revenue growth relative to peers indicates market share gains or losses. The peer section shows TTM revenue, YoY growth, and operating margin for direct comparisons.