Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in SMMT held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 36.4M | $690.0M | 0.0% | 4.693% | 3.96% |
| 2 | FMR LLC | 10.9M | $205.8M | -18.8% | 1.400% | 0.01% |
| 3 | BlackRock, Inc. | 9.7M | $183.0M | +3.1% | 1.245% | 0.00% |
| 4 | STATE STREET CORP | 7.0M | $133.3M | +5.9% | 0.906% | 0.00% |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 5.7M | $108.3M | β | 0.737% | 0.00% |
| 6 | VANGUARD PORTFOLIO MANAGEMENT LLC | 5.2M | $99.2M | β | 0.675% | 0.01% |
| 7 | UBS Group AG | 3.7M | $70.2M | +325.0% | 0.477% | 0.01% |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | 3.3M | $62.9M | +5.3% | 0.428% | 0.00% |
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2.4M | $45.7M | β | 0.311% | 0.01% |
| 10 | D. E. Shaw & Co., Inc. | 2.2M | $42.5M | +439.9% | 0.289% | 0.04% |
| 11 | MORGAN STANLEY | 1.7M | $31.3M | +78.1% | 0.213% | 0.00% |
| 12 | APEIRON CAPITAL Ltd | 1.3M | $24.8M | -0.0% | 0.169% | 23.22% |
| 13 | Pictet Asset Management Holding SA | 1.3M | $24.0M | -4.4% | 0.171% | 0.03% |
| 14 | CITADEL ADVISORS LLC | 1.1M | $20.1M | -67.0% | 0.137% | 0.01% |
| 15 | TWO SIGMA INVESTMENTS, LP | 981K | $18.6M | +69.7% | 0.127% | 0.02% |
| 16 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 961K | $18.2M | +7.6% | 0.124% | 0.00% |
| 17 | TD ASSET MANAGEMENT INC | 957K | $18.1M | -20.6% | 0.123% | 0.01% |
| 18 | VANGUARD FIDUCIARY TRUST CO | 934K | $17.7M | β | 0.120% | 0.00% |
| 19 | SUPERSTRING CAPITAL MANAGEMENT LP | 893K | $16.9M | β | 0.115% | 12.09% |
| 20 | Point72 Asset Management, L.P. | 801K | $15.2M | β | 0.103% | 0.02% |
| 21 | Rock Springs Capital Management LP | 710K | $13.5M | 0.0% | 0.092% | 0.79% |
| 22 | LMR Partners LLP | 685K | $13.0M | β | 0.088% | 0.10% |
| 23 | abrdn plc | 665K | $12.6M | -28.2% | 0.086% | 0.02% |
| 24 | Squarepoint Ops LLC | 614K | $11.6M | -14.2% | 0.079% | 0.01% |
| 25 | BANK OF AMERICA CORP /DE/ | 599K | $11.4M | +25.4% | 0.077% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in SMMT β a direct measure of their conviction.
Filings activity in SMMT during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new SMMT position in Q1 2026
Institutions that fully closed their SMMT position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 220 | +7.8% | 19.84% | +2.25 pp | $2.16B | +13% |
| Q4 2025 | 204 | 9.7% | 17.59% | 2.04 pp | $1.91B | 10% |
| Q3 2025 | 226 | 3.0% | 19.63% | +0.55 pp | $2.13B | +2.9% |
| Q2 2025 | 233 | +15% | 19.08% | +3.45 pp | $2.07B | +22% |
| Q1 2025 | 203 | +1.5% | 15.63% | +1.91 pp | $1.70B | +14% |
| Q4 2024 | 200 | +27% | 13.72% | 2.43 pp | $1.49B | 15% |
| Q3 2024 | 158 | +31% | 16.15% | +11.13 pp | $1.75B | +222% |
| Q2 2024 | 121 | β | 5.02% | β | $545M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Latest Form 4 transactions by company officers and directors. Insider buys are widely viewed as the highest-conviction signal because executives are risking personal capital.
| Date | Insider | Action | Shares | Price | Value |
|---|---|---|---|---|---|
| Jun 12, 2026 | Zanganeh Mahkam | Buy | 3.8M | $13.12 | $50.0M |
| Jun 4, 2026 | Soni Manmeet Singh | Buy | 25K | $14.46 | $362K |
| Jun 4, 2026 | Zanganeh Mahkam | Buy | 100K | $14.60 | $1.5M |
Quick answers to the most common questions about buying SMMT stock.
Based on Q1 2026 13F filings, institutional ownership of Summit Therapeutics Inc. stands at 19.8%, held across 220 reporting institutions.
BAKER BROS. ADVISORS LP is the largest reported institutional holder of SMMT, with approximately 36,391,063 shares worth $0.69B as of Q1 2026.
Yes β 4 widely-followed marquee investors appear among the top 25 institutional holders of SMMT, including SUSQUEHANNA INTERNATIONAL GROUP, LLP, CITADEL ADVISORS LLC, TWO SIGMA INVESTMENTS, LP, Point72 Asset Management, L.P..
Our composite Smart Money Score for SMMT is 73 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
61 institutions opened new positions in SMMT during Q1 2026, while 45 fully exited. 121 added to existing positions and 37 trimmed.
SMMT institutional ownership rose by 2.25 percentage points quarter-over-quarter, with a net change of +16 holders.
The top 10 institutions account for 76.1% of all reported 13F value in SMMT, and the top 25 account for 88.5%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Summit Therapeutics Inc. (SMMT) Institutional Ownership