Last 43 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -0.31 | — | — | 12.11 | — | — | 2.34 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 877.42 | — | — | — | — | — | — | 678.60 | 2.96 | 8.40 | 215.67 | 62.72 | 126.69 |
| — | — | — | — | — | — | — | +982.0% | -97.7% | -66.7% | +58.2% | -64.5% | +72.4% | |
| P/B Ratio | 0.57 | 1.99 | 1.24 | 1.17 | 1.28 | 1.39 | 1.16 | 1.63 | 0.77 | 0.30 | 0.55 | 0.64 | 0.65 |
| — | +43.4% | +6.8% | -28.0% | +67.0% | +356.7% | +111.1% | +156.5% | +18.3% | -55.4% | -21.9% | -51.3% | -45.0% | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | -1.51 | — | — | -0.11 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | -1.51 | — | — | -0.11 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | — | — | — | — | — | — | -16087.5% | 54.1% | -226.7% | -3771.4% | -696.0% | -1234.9% |
| — | — | — | — | — | — | — | -2211.5% | +104.4% | -326.7% | -344.7% | -796.0% | -1334.9% | |
| Operating Margin | -511875.0% | — | — | — | — | — | — | -131950.0% | -384.3% | -3212.0% | -44725.7% | -9335.1% | -16323.6% |
| — | — | — | — | — | — | — | -1313.5% | +97.6% | -18.8% | -324.4% | -44.5% | -538.1% | |
| Net Margin | -291987.5% | — | — | — | — | — | — | -394550.0% | -524.9% | -3073.3% | -42994.3% | -8978.2% | -15750.9% |
| — | — | — | — | — | — | — | -4294.6% | +96.7% | -16.3% | -312.5% | -40.2% | -518.0% |
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -84.3% | -20.1% | -4.1% | 2.5% | -5.5% | -0.8% | 21.0% | -112.8% | -33.8% | -24.6% | -24.4% | -20.6% | -18.2% |
| — | -2396.3% | -119.6% | +102.2% | +83.7% | +96.7% | +186.2% | -446.2% | -85.1% | -49.6% | -92.0% | -84.7% | -86.7% | |
| ROA | -49.0% | -13.6% | -3.0% | 1.7% | -3.5% | -0.6% | 10.7% | -56.6% | -20.5% | -16.6% | -17.4% | -15.3% | -14.0% |
| — | -2357.5% | -128.1% | +103.0% | +82.8% | +96.7% | +161.2% | -269.9% | -46.8% | -25.9% | -66.5% | -63.4% | -69.0% | |
| ROIC | -205.7% | — | — | — | — | — | — | -40.7% | -21.9% | -29.2% | -26.0% | -16.3% | -13.5% |
| — | — | — | — | — | — | — | -149.6% | -61.8% | -126.2% | -160.9% | -96.0% | -61.3% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | — | — | — | — | — | — | 1.09 | 0.40 | 0.42 | 0.35 | 0.28 | 0.25 |
| — | — | — | — | — | — | — | +286.4% | +64.8% | +106.9% | +93.4% | +71.9% | +75.7% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 2.80 | 2.65 | 3.63 | 3.68 | 2.80 | 2.71 | 3.82 | 3.19 | 2.45 | 4.13 | 5.15 | 6.40 | 6.58 |
| — | -2.2% | -5.0% | +15.1% | +14.3% | -34.5% | -25.8% | -50.1% | -62.8% | -50.8% | -58.8% | -50.3% | -50.2% | |
| Quick Ratio | 2.80 | 2.65 | 3.63 | 3.68 | 2.80 | 2.71 | 3.82 | 3.19 | 2.45 | 4.13 | 5.15 | 6.40 | 6.58 |
| — | -2.2% | -5.0% | +15.1% | +14.3% | -34.5% | -25.8% | -50.1% | -62.8% | -50.8% | -58.8% | -50.3% | -50.2% | |
| Interest Coverage | — | — | — | — | — | — | — | — | — | — | — | -16243.00 | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 43 years · Updated daily
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Start ComparisonSynlogic, Inc.'s current P/E is -0.3x. The average P/E over the last 1 quarters is 12.1x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Synlogic, Inc.'s current operating margin is -511875.0%. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Synlogic, Inc.'s business trajectory between earnings reports.