Spyre Therapeutics, Inc. (SYRE) Stock Price History
Historical prices from 2016 to 2026
- 1M
- +29.3%
- 3M
- +2.1%
- YTD
- +240.1%
- 1Y
- +359.6%
- 3Y
- +117.0%
- 5Y
- -10.4%
Loading 10-year price history...
SYRE Historical Performance
SYRE Annual Returns
Year-by-year price performance · 2016–2026
- 2016 annual price return
- -55.5%
- 2017 annual price return
- +18.4%
- 2018 annual price return
- +39.2%
- 2019 annual price return
- -5.0%
- 2020 annual price return
- +1.5%
- 2021 annual price return
- -44.5%
- 2022 annual price return
- -90.6%
- 2023 annual price return
- +104.4%
- 2024 annual price return
- +8.8%
- 2025 annual price return
- +37.4%
- 2026 annual price return
- +180.2%
SYRE Stock Price Trajectory (2016–2026)
As of November 14, 2026, Spyre Therapeutics, Inc. (SYRE) trades at $104.00, representing a +359.6% return over the past year. The stock has delivered a -42.1% total return over five years (-10.4% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $318.75 on April 8, 2016. From this peak, SYRE has corrected -67.4%, currently trading 36% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers ARRY (-36.3% 1Y), PRTA (-19.8% 1Y), and TRMB (-27.8% 1Y), SYRE has outperformed the peer group average. Compare SYRE vs ARRY →
SYRE Historical Price Data · from 2016
Rows 1–50 of 2,668| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-11-13 | 101.96 | 104.50 | 100.49 | 104.00 | 744K | +1.06% |
| 2026-11-12 | 104.80 | 105.28 | 101.40 | 102.91 | 986K | -3.66% |
| 2026-11-11 | 104.21 | 107.87 | 103.72 | 106.82 | 895K | +2.24% |
| 2026-11-10 | 107.07 | 109.15 | 103.19 | 104.48 | 1.00M | -4.15% |
| 2026-11-09 | 105.59 | 110.64 | 104.41 | 109.00 | 1.39M | +4.95% |
| 2026-11-06 | 98.35 | 104.30 | 97.29 | 103.86 | 1.64M | +7.53% |
| 2026-11-05 | 98.38 | 98.75 | 93.83 | 96.59 | 1.16M | -2.47% |
| 2026-11-04 | 99.00 | 100.00 | 92.77 | 99.04 | 1.50M | -0.23% |
| 2026-11-03 | 97.04 | 100.00 | 96.51 | 99.27 | 905K | +3.94% |
| 2026-11-02 | 97.11 | 98.13 | 93.82 | 95.51 | 752K | -1.09% |
| 2026-10-30 | 96.78 | 98.96 | 94.68 | 96.56 | 661K | -2.43% |
| 2026-10-29 | 99.71 | 100.42 | 97.95 | 98.96 | 568K | -0.79% |
| 2026-10-28 | 98.39 | 100.14 | 97.55 | 99.75 | 725K | +0.71% |
| 2026-10-27 | 93.00 | 99.24 | 92.37 | 99.05 | 945K | +6.61% |
| 2026-10-26 | 91.54 | 94.19 | 90.35 | 92.91 | 637K | +2.86% |
| 2026-10-23 | 90.71 | 91.90 | 88.69 | 90.33 | 503K | -2.17% |
| 2026-10-22 | 92.95 | 94.57 | 91.27 | 92.33 | 803K | -0.67% |
| 2026-10-21 | 92.78 | 95.17 | 92.32 | 92.95 | 1.15M | +1.70% |
| 2026-10-20 | 85.12 | 93.22 | 85.08 | 91.40 | 1.71M | +7.88% |
| 2026-10-19 | 82.29 | 86.05 | 80.94 | 84.72 | 1.27M | +6.03% |
| 2026-10-16 | 80.21 | 80.52 | 78.13 | 79.90 | 1.27M | -0.25% |
| 2026-10-15 | 76.87 | 80.88 | 76.87 | 80.10 | 1.15M | +1.87% |
| 2026-10-14 | 80.13 | 82.45 | 77.95 | 78.63 | 1.62M | -2.26% |
| 2026-10-13 | 85.12 | 85.32 | 80.45 | 80.45 | 1.44M | -6.34% |
| 2026-10-12 | 86.30 | 86.62 | 84.21 | 85.90 | 874K | +0.25% |
| 2026-10-09 | 79.90 | 86.22 | 78.73 | 85.69 | 1.12M | +7.25% |
| 2026-10-08 | 79.58 | 80.91 | 77.05 | 79.90 | 2.33M | -1.18% |
| 2026-10-07 | 78.91 | 82.22 | 78.00 | 80.85 | 2.72M | +0.92% |
| 2026-10-06 | 92.08 | 92.08 | 79.36 | 80.11 | 4.25M | -13.60% |
| 2026-10-05 | 93.02 | 95.01 | 89.49 | 92.72 | 643K | -0.50% |
| 2026-10-02 | 91.16 | 95.27 | 90.48 | 93.19 | 1.24M | +3.63% |
| 2026-10-01 | 89.13 | 94.06 | 87.25 | 89.93 | 1.66M | +1.01% |
| 2026-09-30 | 88.64 | 95.08 | 88.00 | 89.03 | 2.10M | +5.09% |
| 2026-09-29 | 85.09 | 86.64 | 83.26 | 84.72 | 1.05M | -1.25% |
| 2026-09-28 | 84.72 | 87.12 | 84.00 | 85.79 | 1.05M | +0.12% |
| 2026-09-25 | 88.10 | 88.10 | 85.63 | 85.69 | 560K | -1.61% |
| 2026-09-24 | 87.46 | 87.46 | 82.93 | 87.09 | 1.73M | -1.22% |
| 2026-09-23 | 91.56 | 91.56 | 86.30 | 88.17 | 919K | -4.13% |
| 2026-09-22 | 91.53 | 93.58 | 89.90 | 91.97 | 1.22M | -0.07% |
| 2026-09-21 | 91.07 | 94.06 | 89.65 | 92.03 | 1.45M | +1.97% |
| 2026-09-18 | 92.82 | 93.34 | 89.85 | 90.25 | 3.36M | -2.62% |
| 2026-09-17 | 92.86 | 95.19 | 91.14 | 92.68 | 1.44M | +1.66% |
| 2026-09-16 | 91.38 | 93.07 | 90.48 | 91.17 | 1.26M | +0.24% |
| 2026-09-15 | 90.82 | 91.07 | 88.47 | 90.95 | 859K | +0.17% |
| 2026-09-14 | 90.21 | 91.40 | 89.43 | 90.80 | 1.10M | +0.22% |
| 2026-09-11 | 90.00 | 91.41 | 87.89 | 90.60 | 886K | +2.13% |
| 2026-09-10 | 85.56 | 88.72 | 85.26 | 88.71 | 902K | +2.05% |
| 2026-09-09 | 88.07 | 89.57 | 86.85 | 86.93 | 1.01M | -4.25% |
| 2026-09-08 | 85.00 | 92.10 | 85.00 | 90.79 | 1.25M | +2.03% |
| 2026-09-04 | 86.45 | 89.18 | 84.68 | 88.98 | 804K | +1.98% |
SYRE Chart Terminal
Live VCP patterns, Cup & Handle overlays, support/resistance, and AI trade plans.
Live Breakouts Feed
High-probability breakout stocks crossing their pivot across 5 pattern engines.
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
Peer Comparison
Compare growth, multiples, and margins vs sector.
SYRE — Frequently Asked Questions
Quick answers to the most common questions about buying SYRE stock.
How has SYRE stock performed recently?
SYRE returned +359.6% over the past year, beating its 5-year annualized CAGR of -10.4%. The stock trades above its 200-day moving average, confirming the uptrend.
What is SYRE's all-time high price?
Spyre Therapeutics, Inc. reached $318.75 on 2016-04-08. The 52-week high is $110.64. Current 1-year return of +359.6% places the stock closer to historical peaks.
Where can I download SYRE historical price data?
This page provides SYRE daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2016-2026, downloadable in CSV format.