Spyre Therapeutics, Inc. (SYRE) Stock Price History
Historical prices from 2016 to 2026
- 1M
- +19.4%
- 3M
- +85.0%
- YTD
- +187.4%
- 1Y
- +448.6%
- 3Y
- +110.1%
- 5Y
- -13.9%
Loading 10-year price history...
SYRE Historical Performance
SYRE Annual Returns
Year-by-year price performance · 2016–2026
- 2016 annual price return
- -55.5%
- 2017 annual price return
- +18.4%
- 2018 annual price return
- +39.2%
- 2019 annual price return
- -5.0%
- 2020 annual price return
- +1.5%
- 2021 annual price return
- -44.5%
- 2022 annual price return
- -90.6%
- 2023 annual price return
- +104.4%
- 2024 annual price return
- +8.8%
- 2025 annual price return
- +37.4%
- 2026 annual price return
- +40.6%
SYRE Stock Price Trajectory (2016–2026)
As of June 28, 2026, Spyre Therapeutics, Inc. (SYRE) trades at $87.89, representing a +448.6% return over the past year. The stock has delivered a -51.1% total return over five years (-13.9% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $318.75 on April 8, 2016. From this peak, SYRE has corrected -72.4%, currently trading 106% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers ARRY (+9.5% 1Y), PRTA (+62.1% 1Y), and TRMB (-32.4% 1Y), SYRE has underperformed the peer group average. Compare SYRE vs ARRY →
SYRE Historical Price Data · from 2016
Rows 1–50 of 2,571| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-06-26 | 88.44 | 89.88 | 85.97 | 87.89 | 0 | -0.88% |
| 2026-06-25 | 86.46 | 89.67 | 84.96 | 88.67 | 1.86M | +2.91% |
| 2026-06-24 | 83.22 | 88.05 | 81.65 | 86.16 | 4.03M | -11.22% |
| 2026-06-23 | 97.92 | 102.06 | 95.31 | 97.05 | 2.54M | -3.26% |
| 2026-06-22 | 95.00 | 101.70 | 95.00 | 100.32 | 2.77M | +13.56% |
| 2026-06-18 | 89.55 | 90.99 | 86.22 | 88.34 | 1.97M | +0.97% |
| 2026-06-17 | 84.73 | 88.03 | 83.17 | 87.49 | 1.50M | +4.90% |
| 2026-06-16 | 83.54 | 84.92 | 81.70 | 83.40 | 1.04M | -0.22% |
| 2026-06-15 | 81.57 | 84.69 | 80.79 | 83.58 | 203K | +3.45% |
| 2026-06-12 | 81.09 | 84.43 | 80.71 | 80.79 | 787K | +0.02% |
| 2026-06-11 | 75.74 | 81.62 | 75.35 | 80.77 | 1.25M | +7.58% |
| 2026-06-10 | 75.91 | 79.52 | 74.79 | 75.08 | 954K | -1.78% |
| 2026-06-09 | 72.97 | 77.11 | 70.89 | 76.44 | 1.53M | +6.17% |
| 2026-06-08 | 75.53 | 76.31 | 71.11 | 72.00 | 946K | -2.24% |
| 2026-06-05 | 77.92 | 78.90 | 73.06 | 73.65 | 946K | -6.08% |
| 2026-06-04 | 73.57 | 79.54 | 73.30 | 78.42 | 951K | +6.91% |
| 2026-06-03 | 70.05 | 76.11 | 69.81 | 73.35 | 1.58M | +6.06% |
| 2026-06-02 | 69.99 | 70.50 | 68.56 | 69.16 | 795K | -1.96% |
| 2026-06-01 | 73.05 | 73.05 | 68.97 | 70.54 | 895K | -4.03% |
| 2026-05-29 | 72.42 | 74.00 | 71.52 | 73.50 | 879K | +1.93% |
| 2026-05-28 | 72.01 | 73.33 | 71.08 | 72.11 | 421K | -0.55% |
| 2026-05-27 | 73.93 | 74.35 | 72.24 | 72.51 | 550K | -1.49% |
| 2026-05-26 | 74.87 | 75.81 | 72.11 | 73.61 | 470K | -0.59% |
| 2026-05-22 | 75.34 | 75.63 | 74.00 | 74.05 | 550K | -0.36% |
| 2026-05-21 | 70.89 | 74.43 | 70.55 | 74.32 | 680K | +3.44% |
| 2026-05-20 | 68.64 | 72.47 | 67.88 | 71.85 | 1.04M | +7.85% |
| 2026-05-19 | 67.60 | 69.54 | 64.75 | 66.62 | 1.35M | -4.94% |
| 2026-05-18 | 75.09 | 75.60 | 69.01 | 70.08 | 1.06M | -6.51% |
| 2026-05-15 | 77.08 | 77.08 | 72.54 | 74.96 | 1.32M | -0.91% |
| 2026-05-14 | 77.76 | 77.76 | 74.49 | 75.65 | 369K | -0.86% |
| 2026-05-13 | 75.55 | 78.00 | 73.48 | 76.31 | 752K | +1.69% |
| 2026-05-12 | 75.87 | 76.94 | 73.22 | 75.04 | 998K | -1.82% |
| 2026-05-11 | 75.15 | 78.80 | 74.39 | 76.43 | 1.31M | +1.85% |
| 2026-05-08 | 73.10 | 75.91 | 72.40 | 75.05 | 833K | +2.66% |
| 2026-05-07 | 73.99 | 74.50 | 71.13 | 73.10 | 915K | +0.14% |
| 2026-05-06 | 72.01 | 73.45 | 70.11 | 73.00 | 664K | +2.90% |
| 2026-05-05 | 70.64 | 73.22 | 70.21 | 70.94 | 1.67M | +2.62% |
| 2026-05-04 | 68.26 | 71.67 | 67.18 | 69.13 | 698K | -0.42% |
| 2026-05-01 | 74.09 | 76.00 | 69.23 | 69.42 | 1.43M | -6.76% |
| 2026-04-30 | 72.33 | 75.00 | 72.08 | 74.45 | 918K | +3.56% |
| 2026-04-29 | 67.99 | 73.61 | 67.50 | 71.89 | 1.69M | +4.75% |
| 2026-04-28 | 72.29 | 73.95 | 68.20 | 68.63 | 1.01M | -4.55% |
| 2026-04-27 | 71.25 | 72.30 | 69.53 | 71.90 | 605K | +3.20% |
| 2026-04-24 | 69.83 | 70.23 | 68.43 | 69.67 | 500K | +0.62% |
| 2026-04-23 | 73.02 | 73.73 | 68.33 | 69.24 | 646K | -5.15% |
| 2026-04-22 | 72.96 | 74.35 | 71.71 | 73.00 | 1.02M | +2.43% |
| 2026-04-21 | 73.39 | 74.61 | 69.95 | 71.27 | 1.27M | -2.89% |
| 2026-04-20 | 72.20 | 74.68 | 72.03 | 73.39 | 874K | +0.52% |
| 2026-04-17 | 70.32 | 74.60 | 70.21 | 73.01 | 1.85M | +4.75% |
| 2026-04-16 | 68.94 | 70.30 | 66.88 | 69.70 | 2.19M | +1.03% |
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
DCA Calculator
See how regular investing compounds over time.
Peer Comparison
Compare growth, multiples, and margins vs sector.
SYRE — Frequently Asked Questions
Quick answers to the most common questions about buying SYRE stock.
How has SYRE stock performed recently?
SYRE returned +448.6% over the past year, beating its 5-year annualized CAGR of -13.9%. The stock trades above its 200-day moving average, confirming the uptrend.
What is SYRE's all-time high price?
Spyre Therapeutics, Inc. reached $318.75 on 2016-04-08. The 52-week high is $102.06. Current 1-year return of +448.6% places the stock closer to historical peaks.
Where can I download SYRE historical price data?
This page provides SYRE daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2016-2026, downloadable in CSV format.