Spyre Therapeutics, Inc. (SYRE) Stock Price History
Historical prices from 2016 to 2026
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SYRE Historical Performance
Short-Term Returns
SYRE Stock Price Trajectory (2016–2026)
As of May 8, 2026, Spyre Therapeutics, Inc. (SYRE) trades at $73.10, representing a +475.1% return over the past year. The stock has delivered a -59.6% total return over five years (-16.6% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $318.75 on April 8, 2016. From this peak, SYRE has corrected -77.1%, currently trading 126% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers ARRY (+62.7% 1Y), PRTA (+44.4% 1Y), and TRMB (-6.7% 1Y), SYRE has underperformed the peer group average. Compare SYRE vs ARRY →
SYRE Historical Price Data (2025–2026)
Showing 30 of 2,537 recordsLoading full history…
| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-05-07 | 73.99 | 74.50 | 71.13 | 73.10 | 915K | +0.14% |
| 2026-05-06 | 72.01 | 73.45 | 70.11 | 73.00 | 664K | +2.90% |
| 2026-05-05 | 70.64 | 73.22 | 70.21 | 70.94 | 1.67M | +2.62% |
| 2026-05-04 | 68.26 | 71.67 | 67.18 | 69.13 | 698K | -0.42% |
| 2026-05-01 | 74.09 | 76.00 | 69.23 | 69.42 | 1.43M | -6.76% |
| 2026-04-30 | 72.33 | 75.00 | 72.08 | 74.45 | 918K | +3.56% |
| 2026-04-29 | 67.99 | 73.61 | 67.50 | 71.89 | 1.69M | +4.75% |
| 2026-04-28 | 72.29 | 73.95 | 68.20 | 68.63 | 1.01M | -4.55% |
| 2026-04-27 | 71.25 | 72.30 | 69.53 | 71.90 | 605K | +3.20% |
| 2026-04-24 | 69.83 | 70.23 | 68.43 | 69.67 | 500K | +0.62% |
| 2026-04-23 | 73.02 | 73.73 | 68.33 | 69.24 | 646K | -5.15% |
| 2026-04-22 | 72.96 | 74.35 | 71.71 | 73.00 | 1.02M | +2.43% |
| 2026-04-21 | 73.39 | 74.61 | 69.95 | 71.27 | 1.27M | -2.89% |
| 2026-04-20 | 72.20 | 74.68 | 72.03 | 73.39 | 874K | +0.52% |
| 2026-04-17 | 70.32 | 74.60 | 70.21 | 73.01 | 1.85M | +4.75% |
| 2026-04-16 | 68.94 | 70.30 | 66.88 | 69.70 | 2.19M | +1.03% |
| 2026-04-15 | 67.75 | 69.45 | 64.60 | 68.99 | 4.04M | +7.78% |
| 2026-04-14 | 67.68 | 67.68 | 60.75 | 64.01 | 1.64M | +1.17% |
| 2026-04-13 | 66.55 | 75.00 | 59.02 | 63.27 | 5.28M | +23.36% |
| 2026-04-10 | 51.40 | 52.98 | 50.85 | 51.29 | 476K | -0.93% |
| 2026-04-09 | 51.75 | 52.73 | 51.25 | 51.77 | 559K | -0.40% |
| 2026-04-08 | 53.03 | 54.49 | 50.39 | 51.98 | 986K | +1.52% |
| 2026-04-07 | 48.97 | 51.24 | 48.83 | 51.20 | 799K | +4.53% |
| 2026-04-06 | 47.58 | 49.85 | 46.79 | 48.98 | 715K | +2.94% |
| 2026-04-02 | 47.17 | 48.40 | 46.27 | 47.58 | 432K | -2.70% |
| 2026-04-01 | 50.45 | 51.00 | 48.64 | 48.90 | 582K | -3.05% |
| 2026-03-31 | 46.28 | 51.06 | 46.28 | 50.44 | 1.06M | +11.05% |
| 2026-03-30 | 47.75 | 48.47 | 44.80 | 45.42 | 705K | -3.99% |
| 2026-03-27 | 47.24 | 47.95 | 46.70 | 47.31 | 815K | -0.44% |
| 2026-03-26 | 45.39 | 49.30 | 45.23 | 47.52 | 1.06M | +4.03% |
Full SYRE Stock Analysis
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View ValuationCompare SYRE vs DBVT
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Start ComparisonSYRE — Frequently Asked Questions
Quick answers to the most common questions about buying SYRE stock.
How has SYRE stock performed recently?
SYRE returned +475.1% over the past year, beating its 5-year annualized CAGR of -16.6%. The stock trades above its 200-day moving average, confirming the uptrend.
What is SYRE's all-time high price?
Spyre Therapeutics, Inc. reached $318.75 on 2016-04-08. The 52-week high is $76.00. Current 1-year return of +475.1% places the stock closer to historical peaks.
Where can I download SYRE historical price data?
This page provides SYRE daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2016-2026, downloadable in CSV format.