Talphera, Inc. (TLPH) Financial Ratios
18 years of historical data (2008–2025) · Healthcare · Drug Manufacturers - Specialty & Generic
EV/EBITDA
N/A
—
5yr avg: N/A
P/FCF
N/A
—
5yr avg: N/A
P/B Ratio
↑
2.71
↑+80% vs avg
5yr avg: 1.51
30Y Low0.7·High31.7
ROE
↓
-114.2%
↑-228% vs avg
5yr avg: -34.8%
30Y Low-311%·High195%
Debt/EBITDA
N/A
—
5yr avg: N/A
Percentile shows where the current value sits in 30-year historical distribution. Sparklines show 5-year trend.
TLPH Valuation Multiples
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
Talphera, Inc. currently has a negative P/E ratio, indicating the company is operating at a loss on a trailing-twelve-month basis.
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $46M | $48M | $14M | $11M | $17M | $67M | $106M | $167M | $135M | $95M | $118M |
| Enterprise Value | $47M | $49M | $11M | $5M | $11M | $78M | $104M | $274M | $153M | $145M | $132M |
| P/E Ratio → | -3.21 | — | — | — | 0.40 | — | — | — | — | — | — |
| P/S Ratio | 1650.99 | 1726.72 | — | 16.21 | — | 177.57 | 19.52 | 72.99 | 62.73 | 11.90 | 6.79 |
| P/B Ratio | 2.71 | 2.84 | 1.69 | 0.75 | 0.77 | — | — | — | 31.72 | — | — |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — |
| P/OCF | — | — | — | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
TLPH EV Ratios
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 1748.33 | — | 7.43 | — | 206.56 | 19.21 | 119.78 | 70.95 | 18.13 | 7.61 |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | 0.19 | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | — | — | — | — | — |
TLPH Profitability
Margins and return-on-capital ratios measuring operating efficiency
Talphera, Inc. earns an operating margin of -48157.1%. Operating margins have compressed from -2594.3% to -48157.1% over the past 3 years, signaling potential cost pressures or competitive headwinds. A negative ROE of -114.2% indicates the company is currently destroying shareholder equity.
Margins
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | 100.0% | — | -751.9% | — | -695.2% | -11.4% | -197.3% | -84.8% | -33.3% | 29.0% |
| Operating Margin | -48157.1% | -48157.1% | — | -2594.3% | — | -4792.6% | -756.3% | -2368.1% | -1660.9% | -483.8% | -184.1% |
| Net Profit Margin | -51035.7% | -51035.7% | — | -2826.0% | — | -9285.4% | -745.6% | -2325.9% | -2192.0% | -644.3% | -248.6% |
Return on Capital
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -114.2% | -114.2% | -117.7% | -102.4% | 194.9% | — | — | — | -1108.6% | — | -310.8% |
| ROA | -59.6% | -59.6% | -67.3% | -54.2% | 67.8% | -48.7% | -51.2% | -50.3% | -48.1% | -58.7% | -37.9% |
| ROIC | -86.8% | -86.8% | -162.8% | -101.6% | -92.2% | — | -743.4% | -92.8% | -152.2% | -261.8% | -257.5% |
| ROCE | -65.0% | -65.0% | -96.9% | -68.1% | -43.7% | -33.5% | -64.8% | -59.5% | -42.9% | -51.0% | -31.2% |
TLPH Leverage & Debt
Solvency and debt-coverage ratios — lower is generally safer
Net debt stands at $605000 ($6M total debt minus $6M cash).
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.38 | 0.38 | 0.82 | — | 0.46 | — | — | — | 24.85 | — | — |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | 0.04 | -0.29 | -0.41 | -0.24 | — | — | — | 4.16 | — | — |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | — | — | — | — | — |
| Interest Coverage | — | — | -38.71 | -126.04 | 53.99 | -7.91 | -11.22 | -20.00 | -2.75 | -2.72 | -2.55 |
TLPH Liquidity & Efficiency
Short-term solvency ratios and asset-utilisation metrics
Talphera, Inc.'s current ratio of 5.49x is well above the 1.0 safety threshold, indicating strong short-term liquidity with ample room to cover current liabilities. The current ratio has improved from 2.56x to 5.49x over the past 3 years.
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.49 | 5.49 | 3.56 | 2.56 | 1.78 | 2.73 | 2.66 | 5.27 | 6.78 | 4.64 | 8.74 |
| Quick Ratio | 5.49 | 5.49 | 3.56 | 2.56 | 1.70 | 2.67 | 2.56 | 5.02 | 6.73 | 4.57 | 8.53 |
| Cash Ratio | 5.35 | 5.35 | 3.35 | 2.08 | 1.15 | 2.52 | 2.43 | 4.86 | 6.64 | 4.43 | 7.88 |
| Asset Turnover | — | 0.00 | — | 0.03 | — | 0.00 | 0.08 | 0.03 | 0.02 | 0.11 | 0.17 |
| Inventory Turnover | — | — | — | — | 1.40 | 2.71 | 3.71 | 2.07 | 4.66 | 11.15 | 5.72 |
| Days Sales Outstanding | — | — | — | — | — | 154.50 | 42.79 | 68.89 | 68.05 | 69.99 | 122.66 |
TLPH Shareholder Yields
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Talphera, Inc. does not currently pay a dividend and has no material buyback yield, reinvesting earnings back into the business.
Dividends
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
Total Shareholder Return Metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | 253.1% | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | — | — | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $42M | $26M | $14M | $7M | $6M | $4M | $4M | $3M | $2M | $2M |
Peer Comparison
Compare TLPH with 10 similar companies in its peer group
| Company | Market Cap | P/E | EV/EBITDA | P/FCF | Gross Margin | Op Margin | ROE | ROIC | Debt/EBITDA |
|---|---|---|---|---|---|---|---|---|---|
 TLPHYou | $46M | -3.2 | — | — | 100.0% | -48157.1% | -114.2% | -86.8% | — |
 PRGO | $1B | -1.0 | 7.1 | 9.8 | 35.1% | 8.1% | -39.3% | 3.7% | 5.8 |
 HALO | $8B | 26.8 | 11.2 | 12.6 | 78.1% | 58.4% | 153.6% | 32.1% | 2.4 |
 NKTR | $1B | -6.3 | — | — | 100.0% | -236.8% | -217.9% | -57.2% | — |
 PCRX | $878M | 139.6 | 9.4 | 6.4 | 79.4% | 4.6% | 1.0% | 2.3% | 3.7 |
 INVA | $2B | 6.8 | 6.8 | 8.5 | 72.3% | 38.5% | 29.1% | 14.2% | 1.3 |
 MCK | $90B | 19.6 | 13.2 | 15.8 | 3.6% | 1.6% | — | 254.1% | 1.2 |
 CAH | $52B | 34.4 | 18.8 | 28.2 | 3.7% | 1.0% | — | 3378.7% | 3.0 |
 XTLB | $279464 | -0.3 | — | — | 0.7% | -481.6% | -26.8% | -54.1% | — |
 SPRO | $132M | 15.2 | — | — | 100.0% | -0.0% | 16.3% | -0.2% | — |
 LQDA | $6B | -88.8 | — | — | 91.6% | -32.5% | -113.0% | -102.5% | — |
| Healthcare Median | — | 22.1 | 14.2 | 18.5 | 63.9% | -4.3% | -32.6% | -11.6% | 3.2 |
Peer selection based on competitive and market overlap. Compare multiple stocks →
Download Financial Ratios Data
Includes 30+ ratios · 18 years · Updated daily
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TLPH — Frequently Asked Questions
Quick answers to the most common questions about buying TLPH stock.
What is Talphera, Inc.'s P/E ratio?
Talphera, Inc.'s current P/E ratio is -3.2x. The historical average is 0.4x.
What is Talphera, Inc.'s ROE?
Talphera, Inc.'s return on equity (ROE) is -114.2%. The historical average is -85.6%.
Is TLPH stock overvalued?
Based on historical data, Talphera, Inc. is trading at a P/E of -3.2x. Compare with industry peers and growth rates for a complete picture.
What are Talphera, Inc.'s profit margins?
Talphera, Inc. has 100.0% gross margin and -48157.1% operating margin.