Talphera, Inc. (TLPH) P/E Ratio History
Deep ValueTrading at -3.0x · 0th percentile of 5-year range · Significant discount to historical valuation · Data 2022–2023
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P/E Ratio Analysis
As of June 29, 2026, Talphera, Inc. (TLPH) trades at a price-to-earnings ratio of -3.0x, with a stock price of $1.03 and trailing twelve-month earnings per share of $-0.34.
The current P/E is 724% below its 5-year average of 0.5x. Over the past five years, TLPH's P/E has ranged from a low of 0.1x to a high of 0.8x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.0x, TLPH trades at a 113% discount to its sector peers. The sector includes 231 companies with P/E ratios ranging from 0.0x to 191.4x.
Relative to the broader market, TLPH trades at a notable discount to the S&P 500 median P/E of 25.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our TLPH DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
TLPH Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
TLPH P/E vs Peers
Complex generics and injectables peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $9B | 29.3 | 1.27 | -25% | |
| $993M | 157.8 | - | +107% | |
| $2B | 7.1Lowest | 0.69Best | +817%Best | |
| $92B | 19.9 | - | +49% | |
| $56B | 36.9 | - | +87% | |
| $131M | 15.1 | - | +112% |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
TLPH Historical P/E Data (2022–2023)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2023 Q1 | Mar 31 2023 | $0.66 | $7.67 | 0.1x | -82% |
| FY2022 Q4 | Dec 31 2022 | $2.26 | $6.47 | 0.3x | -28% |
| FY2022 Q3 | Sep 30 2022 | $4.20 | $6.23 | 0.7x | +39% |
| FY2022 Q2 | - | $4.80 | $5.77 | 0.8x | +71% |
Average P/E for displayed period: 0.5x
Intrinsic Valuation
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Historical Returns
4+ years return with dividends reinvested.
DCA Calculator
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Peer Comparison
Compare growth, multiples, and margins vs sector.
TLPH — Frequently Asked Questions
Quick answers to the most common questions about buying TLPH stock.
What is TLPH's P/E ratio?
Talphera, Inc. (TLPH) trailing twelve-month P/E ratio is -3.0x, based on TTM diluted EPS of $-0.34. The 5-year average P/E is 0.5x and the historical range spans 0.1x to 0.8x.
Is TLPH stock overvalued or undervalued?
TLPH trades at -3.0x P/E, below its 5-year average of 0.5x. At the 0th percentile of its historical range (0.1x–0.8x), the stock is priced at a discount to its own history.
Is TLPH stock expensive?
No, TLPH is not expensive on a historical basis. The current P/E of -3.0x is below the 5-year average of 0.5x and sits at the 0th percentile of its valuation range.
What is TLPH's historical P/E range?
Over the past 5 years, TLPH's P/E ratio has ranged from 0.1x to 0.8x, with a median of 0.7x and an average of 0.5x. The current P/E of -3.0x places the stock at the 0th percentile of this range. Full historical data spans 2022–2023.
How does TLPH's P/E compare to the S&P 500?
TLPH trades at -3.0x P/E versus the S&P 500 median of 25.3x. The 112% discount to the market suggests lower growth expectations or perceived higher risk.
How does TLPH's valuation compare to Healthcare peers?
Talphera, Inc. P/E of -3.0x compares to the Healthcare sector median of 23.0x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is TLPH's PEG ratio?
TLPH PEG ratio is N/A, based on a P/E of -3.0x and EPS growth of 32.0%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is TLPH's earnings yield?
TLPH earnings yield is N/A, the inverse of its -3.0x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.