Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in TYRA held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 12.2M | $467.2M | 0.0% | 20.512% | 4.95% |
| 2 | FMR LLC | 7.7M | $296.7M | +61570.4% | 13.028% | 0.02% |
| 3 | Nextech Invest, Ltd. | 4.1M | $155.3M | 0.0% | 6.820% | 10.93% |
| 4 | JANUS HENDERSON GROUP PLC | 3.9M | $148.9M | +32.5% | 6.542% | 0.07% |
| 5 | Alta Partners Management Company, L.P. | 3.8M | $146.4M | 0.0% | 6.429% | 96.97% |
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 3.6M | $137.1M | +73.3% | 6.021% | 0.89% |
| 7 | TCG Crossover Management, LLC | 3.2M | $124.4M | +12.1% | 5.463% | 3.56% |
| 8 | COMMODORE CAPITAL LP | 2.5M | $94.8M | -26.7% | 4.162% | 5.48% |
| 9 | BlackRock, Inc. | 2.2M | $84.9M | +6.3% | 3.730% | 0.00% |
| 10 | Paradigm Biocapital Advisors LP | 2.1M | $78.7M | β | 3.456% | 1.61% |
| 11 | BVF INC/IL | 2.0M | $75.7M | -7.1% | 3.323% | 2.41% |
| 12 | Caligan Partners LP | 1.3M | $48.9M | +35.2% | 2.147% | 3.40% |
| 13 | STATE STREET CORP | 1.2M | $46.6M | +62.3% | 2.045% | 0.00% |
| 14 | VANGUARD CAPITAL MANAGEMENT LLC | 1.1M | $43.1M | β | 1.893% | 0.00% |
| 15 | 5AM Venture Management, LLC | 1.0M | $39.4M | 0.0% | 1.731% | 10.94% |
| 16 | Logos Global Management LP | 850K | $32.6M | +304.8% | 1.429% | 1.63% |
| 17 | BARCLAYS PLC | 833K | $31.9M | +992.1% | 1.401% | 0.01% |
| 18 | Canaan Partners XI LLC | 750K | $28.7M | -77.8% | 1.261% | 37.76% |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 658K | $25.2M | +0.1% | 1.107% | 0.00% |
| 20 | JENNISON ASSOCIATES LLC | 632K | $24.2M | β | 1.064% | 0.02% |
| 21 | Sio Capital Management, LLC | 605K | $23.2M | +15.1% | 1.018% | 3.34% |
| 22 | GOLDMAN SACHS GROUP INC | 550K | $21.1M | +201.7% | 0.925% | 0.00% |
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 549K | $21.0M | β | 0.923% | 0.25% |
| 24 | BALYASNY ASSET MANAGEMENT LLC | 351K | $13.5M | -57.0% | 0.591% | 0.05% |
| 25 | Elmind Capital, LP | 350K | $13.4M | 0.0% | 0.588% | 3.81% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in TYRA β a direct measure of their conviction.
Filings activity in TYRA during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new TYRA position in Q1 2026
Institutions that fully closed their TYRA position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 160 | +20% | 154.46% | +61.70 pp | $2.48B | +67% |
| Q4 2025 | 133 | +17% | 92.76% | +44.38 pp | $1.49B | +92% |
| Q3 2025 | 114 | 6.6% | 48.38% | +14.73 pp | $776M | +44% |
| Q2 2025 | 122 | +3.4% | 33.65% | +2.63 pp | $540M | +8.5% |
| Q1 2025 | 118 | +4.4% | 31.02% | 10.98 pp | $498M | 26% |
| Q4 2024 | 113 | +19% | 42.00% | 26.81 pp | $674M | 39% |
| Q3 2024 | 95 | +19% | 68.81% | +22.38 pp | $1.10B | +48% |
| Q2 2024 | 80 | β | 46.43% | β | $745M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying TYRA stock.
Based on Q1 2026 13F filings, institutional ownership of Tyra Biosciences, Inc. stands at 154.5%, held across 160 reporting institutions.
RA CAPITAL MANAGEMENT, L.P. is the largest reported institutional holder of TYRA, with approximately 12,198,625 shares worth $0.47B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of TYRA.
Our composite Smart Money Score for TYRA is 58 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
43 institutions opened new positions in TYRA during Q1 2026, while 16 fully exited. 99 added to existing positions and 16 trimmed.
TYRA institutional ownership rose by 61.70 percentage points quarter-over-quarter, with a net change of +27 holders.
The top 10 institutions account for 70.0% of all reported 13F value in TYRA, and the top 25 account for 89.7%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Tyra Biosciences, Inc. (TYRA) Institutional Ownership