| 4 |
| Alta Partners Management Company, L.P. |
| 3.8M |
| $122.1M |
| 0.0% |
| 6.408% |
| 95.92% |
| 5 | Nextech Invest Ltd. | 3.6M | $113.5M | -12.4% | 5.956% | 5.39% |
| 6 | TCG Crossover Management, LLC | 3.2M | $103.8M | 0.0% | 5.446% | 2.49% |
| 7 | BlackRock, Inc. | 3.0M | $96.8M | +36.7% | 5.082% | 0.00% |
| 8 | STATE STREET CORP | 2.1M | $68.4M | +76.0% | 3.587% | 0.00% |
| 9 | Commodore Capital LP | 1.9M | $59.9M | -24.2% | 3.143% | 3.57% |
| 10 | Paradigm Biocapital Advisors LP | 1.8M | $58.4M | -11.0% | 3.065% | 1.09% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1.5M | $48.2M | +34.0% | 2.528% | 0.00% |
| 12 | BVF INC/IL | 1.5M | $47.1M | -25.3% | 2.474% | 1.21% |
| 13 | 5AM Venture Management, LLC | 1.0M | $32.9M | 0.0% | 1.725% | 11.42% |
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1.0M | $32.5M | +85.3% | 1.705% | 0.34% |
| 15 | Hood River Capital Management LLC | 1.0M | $32.5M | — | 1.704% | 0.24% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 971K | $31.0M | +47.4% | 1.627% | 0.00% |
| 17 | Caligan Partners LP | 807K | $25.8M | -36.8% | 1.353% | 1.21% |
| 18 | Canaan Partners XI LLC | 750K | $24.0M | 0.0% | 1.257% | 18.82% |
| 19 | Siren, L.L.C. | 725K | $23.2M | — | 1.215% | 0.47% |
| 20 | Sio Capital Management, LLC | 695K | $22.2M | +14.8% | 1.165% | 3.68% |
| 21 | STEMPOINT CAPITAL LP | 633K | $20.2M | +115.8% | 1.060% | 3.48% |
| 22 | MARSHALL WACE, LLP | 583K | $18.6M | +194.9% | 0.977% | 0.01% |
| 23 | GOLDMAN SACHS GROUP INC | 463K | $14.8M | -15.8% | 0.777% | 0.00% |
| 24 | JENNISON ASSOCIATES LLC | 451K | $14.4M | -28.7% | 0.756% | 0.01% |
| 25 | TWO SIGMA INVESTMENTS, LP | 450K | $14.4M | +342.6% | 0.754% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in TYRA — a direct measure of their conviction.
Institutions that fully closed their TYRA position in Q2 2026
| 100.75% |
| +5.07 pp |
| $498M |
| 26% |
| Q4 2024 | 113 | +19% | 95.68% | +6.70 pp | $674M | 39% |
| Q3 2024 | 95 | — | 88.98% | — | $1.10B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
28 institutions opened new positions in TYRA during Q2 2026, while 24 fully exited. 61 added to existing positions and 76 trimmed.
TYRA institutional ownership rose by 5.23 percentage points quarter-over-quarter, with a net change of +4 holders.
The top 10 institutions account for 67.3% of all reported 13F value in TYRA, and the top 25 account for 86.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Tyra Biosciences, Inc. (TYRA) Institutional Ownership