Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in TYRA held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 12.2M | $389.6M | 0.0% | 20.446% | 3.39% |
| 2 | FMR LLC | 8.9M | $284.9M | +15.1% | 14.952% | 0.01% |
| 3 | Jupiter Topco LLC | 4.4M | $139.2M | β | 7.295% | 0.06% |
| 4 | Alta Partners Management Company, L.P. | 3.8M | $122.1M | 0.0% | 6.408% | 95.92% |
| 5 | Nextech Invest Ltd. | 3.6M | $113.5M | -12.4% | 5.956% | 5.39% |
| 6 | TCG Crossover Management, LLC | 3.2M | $103.8M | 0.0% | 5.446% | 2.49% |
| 7 | BlackRock, Inc. | 3.0M | $96.8M | +36.7% | 5.082% | 0.00% |
| 8 | STATE STREET CORP | 2.1M | $68.4M | +76.0% | 3.587% | 0.00% |
| 9 | Commodore Capital LP | 1.9M | $59.9M | -24.2% | 3.143% | 3.57% |
| 10 | Paradigm Biocapital Advisors LP | 1.8M | $58.4M | -11.0% | 3.065% | 1.09% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1.5M | $48.2M | +34.0% | 2.528% | 0.00% |
| 12 | BVF INC/IL | 1.5M | $47.1M | -25.3% | 2.474% | 1.21% |
| 13 | 5AM Venture Management, LLC | 1.0M | $32.9M | 0.0% | 1.725% | 11.42% |
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1.0M | $32.5M | +85.3% | 1.705% | 0.34% |
| 15 | Hood River Capital Management LLC | 1.0M | $32.5M | β | 1.704% | 0.24% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 971K | $31.0M | +47.4% | 1.627% | 0.00% |
| 17 | Caligan Partners LP | 807K | $25.8M | -36.8% | 1.353% | 1.21% |
| 18 | Canaan Partners XI LLC | 750K | $24.0M | 0.0% | 1.257% | 18.82% |
| 19 | Siren, L.L.C. | 725K | $23.2M | β | 1.215% | 0.47% |
| 20 | Sio Capital Management, LLC | 695K | $22.2M | +14.8% | 1.165% | 3.68% |
| 21 | STEMPOINT CAPITAL LP | 633K | $20.2M | +115.8% | 1.060% | 3.48% |
| 22 | MARSHALL WACE, LLP | 583K | $18.6M | +194.9% | 0.977% | 0.01% |
| 23 | GOLDMAN SACHS GROUP INC | 463K | $14.8M | -15.8% | 0.777% | 0.00% |
| 24 | JENNISON ASSOCIATES LLC | 451K | $14.4M | -28.7% | 0.756% | 0.01% |
| 25 | TWO SIGMA INVESTMENTS, LP | 450K | $14.4M | +342.6% | 0.754% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in TYRA β a direct measure of their conviction.
Filings activity in TYRA during Q2 2026, grouped by how each filer changed its position.
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 168 | +2.4% | 116.93% | +5.23 pp | $2.14B | 15% |
| Q1 2026 | 164 | +22% | 111.70% | +5.87 pp | $2.50B | +68% |
| Q4 2025 | 134 | +17% | 105.83% | +1.43 pp | $1.49B | +91% |
| Q3 2025 | 115 | 5.7% | 104.40% | 1.90 pp | $778M | +44% |
| Q2 2025 | 122 | +3.4% | 106.30% | +5.55 pp | $540M | +8.5% |
| Q1 2025 | 118 | +4.4% | 100.75% | +5.07 pp | $498M | 26% |
| Q4 2024 | 113 | +19% | 95.68% | +6.70 pp | $674M | 39% |
| Q3 2024 | 95 | β | 88.98% | β | $1.10B | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying TYRA stock.
Based on Q2 2026 13F filings, institutional ownership of Tyra Biosciences, Inc. stands at 116.9%, held across 168 reporting institutions.
RA CAPITAL MANAGEMENT, L.P. is the largest reported institutional holder of TYRA, with approximately 12,198,625 shares worth $0.39B as of Q2 2026.
Yes β 1 widely-followed marquee investor appear among the top 25 institutional holders of TYRA, including TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for TYRA is 60 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
28 institutions opened new positions in TYRA during Q2 2026, while 24 fully exited. 61 added to existing positions and 76 trimmed.
TYRA institutional ownership rose by 5.23 percentage points quarter-over-quarter, with a net change of +4 holders.
The top 10 institutions account for 67.3% of all reported 13F value in TYRA, and the top 25 account for 86.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Tyra Biosciences, Inc. (TYRA) Institutional Ownership