Comprehensive Stock Comparison
Compare Puma Biotechnology, Inc. (PBYI) vs Exelixis, Inc. (EXEL) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | EXEL | 7.0% revenue growth vs PBYI's -0.9% |
| Value | EXEL | Lower P/E (13.3x vs 22.8x) |
| Quality / Margins | EXEL | 29.6% net margin vs PBYI's 13.6% |
| Stability / Safety | PBYI | Beta 0.54 vs EXEL's 0.63 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | PBYI | +59.2% vs EXEL's +13.9% |
| Efficiency (ROA) | EXEL | 24.0% ROA vs PBYI's 14.4%, ROIC 32.1% vs 24.7% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Puma Biotechnology is a biopharmaceutical company focused on developing and commercializing targeted cancer therapies, primarily for HER2-positive breast cancer. It generates revenue through sales of its FDA-approved drug neratinib (marketed as NERLYNX) and licensing agreements with pharmaceutical partners worldwide. The company's moat lies in its specialized expertise in HER2-targeted oncology and its patent-protected neratinib franchise, which addresses a specific niche in breast cancer treatment.
Exelixis is an oncology-focused biotechnology company that discovers, develops, and commercializes targeted cancer therapies. It generates revenue primarily from sales of its flagship drug Cabometyx — which accounts for the vast majority of its revenue — along with royalties from partnered products like Cotellic. The company's competitive advantage lies in its deep expertise in tyrosine kinase inhibitors and its focused pipeline targeting difficult-to-treat cancers.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
EXEL leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). PBYI leads in 1 (Valuation Metrics). 1 tied.
Financial Metrics (TTM)
EXEL is the larger business by revenue, generating $2.3B annually — 10.0x PBYI's $228M. EXEL is the more profitable business, keeping 29.6% of every revenue dollar as net income compared to PBYI's 13.6%. On growth, PBYI holds the edge at +27.8% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | PBYIPuma Biotechnolog… | EXELExelixis, Inc. |
|---|---|---|
| RevenueTrailing 12 months | $228M | $2.3B |
| EBITDAEarnings before interest/tax | $46M | $830M |
| Net IncomeAfter-tax profit | $31M | $678M |
| Free Cash FlowCash after capex | $48M | $753M |
| Gross MarginGross profit ÷ Revenue | +74.5% | +96.6% |
| Operating MarginEBIT ÷ Revenue | +16.3% | +35.0% |
| Net MarginNet income ÷ Revenue | +13.6% | +29.6% |
| FCF MarginFCF ÷ Revenue | +21.2% | +32.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | +27.8% | +10.8% |
| EPS Growth (YoY)Latest quarter vs prior year | -33.3% | +75.0% |
Valuation Metrics
At 9.3x trailing earnings, PBYI trades at a 41% valuation discount to EXEL's 15.8x P/E. On an enterprise value basis, PBYI's 7.7x EV/EBITDA is more attractive than EXEL's 13.2x.
| Metric | PBYIPuma Biotechnolog… | EXELExelixis, Inc. |
|---|---|---|
| Market CapShares × price | $287M | $11.8B |
| Enterprise ValueMkt cap + debt − cash | $286M | $11.5B |
| Trailing P/EPrice ÷ TTM EPS | 9.34x | 15.85x |
| Forward P/EPrice ÷ next-FY EPS est. | 22.80x | 13.29x |
| PEG RatioP/E ÷ EPS growth rate | — | 0.31x |
| EV / EBITDAEnterprise value multiple | 7.67x | 13.19x |
| Price / SalesMarket cap ÷ Revenue | 1.26x | 5.09x |
| Price / BookPrice ÷ Book value/share | 2.22x | 5.75x |
| Price / FCFMarket cap ÷ FCF | 6.89x | 13.36x |
Profitability & Efficiency
EXEL delivers a 31.4% return on equity — every $100 of shareholder capital generates $31 in annual profit, vs $24 for PBYI. EXEL carries lower financial leverage with a 0.08x debt-to-equity ratio, signaling a more conservative balance sheet compared to PBYI's 0.22x.
| Metric | PBYIPuma Biotechnolog… | EXELExelixis, Inc. |
|---|---|---|
| ROE (TTM)Return on equity | +23.8% | +31.4% |
| ROA (TTM)Return on assets | +14.4% | +24.0% |
| ROICReturn on invested capital | +24.7% | +32.1% |
| ROCEReturn on capital employed | +29.6% | +35.0% |
| Piotroski ScoreFundamental quality 0–9 | 7 | 7 |
| Debt / EquityFinancial leverage | 0.22x | 0.08x |
| Net DebtTotal debt minus cash | -$1M | -$309M |
| Cash & Equiv.Liquid assets | $30M | $482M |
| Total DebtShort + long-term debt | $29M | $173M |
| Interest CoverageEBIT ÷ Interest expense | 5.49x | — |
Total Returns (with DRIP)
A $10,000 investment in EXEL five years ago would be worth $19,758 today (with dividends reinvested), compared to $5,583 for PBYI. Over the past 12 months, PBYI leads with a +59.2% total return vs EXEL's +13.9%. The 3-year compound annual growth rate (CAGR) favors EXEL at 37.1% vs PBYI's 13.9% — a key indicator of consistent wealth creation.
| Metric | PBYIPuma Biotechnolog… | EXELExelixis, Inc. |
|---|---|---|
| YTD ReturnYear-to-date | -1.2% | +1.1% |
| 1-Year ReturnPast 12 months | +59.2% | +13.9% |
| 3-Year ReturnCumulative with dividends | +47.7% | +158.0% |
| 5-Year ReturnCumulative with dividends | -44.2% | +97.6% |
| 10-Year ReturnCumulative with dividends | -87.3% | +1110.4% |
| CAGR (3Y)Annualised 3-year return | +13.9% | +37.1% |
Risk & Volatility
PBYI is the less volatile stock with a 0.54 beta — it tends to amplify market swings less than EXEL's 0.63 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. EXEL currently trades 88.8% from its 52-week high vs PBYI's 74.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | PBYIPuma Biotechnolog… | EXELExelixis, Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.54x | 0.63x |
| 52-Week HighHighest price in past year | $7.68 | $49.62 |
| 52-Week LowLowest price in past year | $2.58 | $32.38 |
| % of 52W HighCurrent price vs 52-week peak | +74.2% | +88.8% |
| RSI (14)Momentum oscillator 0–100 | 69.9 | 53.1 |
| Avg Volume (50D)Average daily shares traded | 343K | 2.1M |
Analyst Outlook
Wall Street rates PBYI as "Buy" and EXEL as "Buy".
| Metric | PBYIPuma Biotechnolog… | EXELExelixis, Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | — | $44.40 |
| # AnalystsCovering analysts | 19 | 32 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +8.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Puma Biotechnology,… (PBYI) | 100 | 63.8 | -36.2% |
| Exelixis, Inc. (EXEL) | 100 | 221.93 | +121.9% |
Exelixis, Inc. (EXEL) returned +98% over 5 years vs Puma Biotechnology,… (PBYI)'s -44%. A $10,000 investment in EXEL 5 years ago would be worth $19,758 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Puma Biotechnology,… (PBYI) | $0.00 | $228M | — |
| Exelixis, Inc. (EXEL) | $191M | $2.3B | +1111.8% |
Puma Biotechnology, Inc.'s revenue grew from $0M (2016) to $228M (2025) — a 0.0% CAGR. Exelixis, Inc.'s revenue grew from $191M (2016) to $2.3B (2025) — a 31.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Puma Biotechnology,… (PBYI) | -10.5% | 13.6% | +229.2% |
| Exelixis, Inc. (EXEL) | -36.7% | 33.7% | +192.0% |
Exelixis, Inc.'s net margin went from -37% (2016) to 34% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Puma Biotechnology,… (PBYI) | 208.4 | 9.8 | -95.3% |
| Exelixis, Inc. (EXEL) | 62 | 15.8 | -74.5% |
Puma Biotechnology, Inc. has traded in a 5x–208x P/E range over 4 years; current trailing P/E is ~9x. Exelixis, Inc. has traded in a 9x–62x P/E range over 9 years; current trailing P/E is ~16x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Puma Biotechnology,… (PBYI) | -8.29 | 0.61 | +107.4% |
| Exelixis, Inc. (EXEL) | -0.28 | 2.78 | +1092.9% |
Puma Biotechnology, Inc.'s EPS grew from $-8.29 (2016) to $0.61 (2025). Exelixis, Inc.'s EPS grew from $-0.28 (2016) to $2.78 (2025).
Chart 6Free Cash Flow — 5 Years
Puma Biotechnology, Inc. generated $42M FCF in 2025 (+102% vs 2021). Exelixis, Inc. generated $884M FCF in 2025 (+163% vs 2021).
PBYI vs EXEL: Frequently Asked Questions
9 questions · data-driven answers · updated daily
01Is PBYI or EXEL a better buy right now?
Puma Biotechnology, Inc. (PBYI) offers the better valuation at 9.3x trailing P/E (22.8x forward), making it the more compelling value choice. Analysts rate Puma Biotechnology, Inc. (PBYI) a "Buy" — based on 19 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — PBYI or EXEL?
On trailing P/E, Puma Biotechnology, Inc. (PBYI) is the cheapest at 9.3x versus Exelixis, Inc. at 15.8x. On forward P/E, Exelixis, Inc. is actually cheaper at 13.3x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — PBYI or EXEL?
Over the past 5 years, Exelixis, Inc. (EXEL) delivered a total return of +97.6%, compared to -44.2% for Puma Biotechnology, Inc. (PBYI). A $10,000 investment in EXEL five years ago would be worth approximately $20K today (assuming dividends reinvested). Over 10 years, the gap is even starker: EXEL returned +1110% versus PBYI's -87.3%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — PBYI or EXEL?
By beta (market sensitivity over 5 years), Puma Biotechnology, Inc. (PBYI) is the lower-risk stock at 0.54β versus Exelixis, Inc.'s 0.63β — meaning EXEL is approximately 16% more volatile than PBYI relative to the S&P 500. On balance sheet safety, Exelixis, Inc. (EXEL) carries a lower debt/equity ratio of 8% versus 22% for Puma Biotechnology, Inc. — giving it more financial flexibility in a downturn.
05Which has better profit margins — PBYI or EXEL?
Exelixis, Inc. (EXEL) is the more profitable company, earning 33.7% net margin versus 13.6% for Puma Biotechnology, Inc. — meaning it keeps 33.7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: EXEL leads at 37.6% versus 16.3% for PBYI. At the gross margin level — before operating expenses — EXEL leads at 96.6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is PBYI or EXEL more undervalued right now?
On forward earnings alone, Exelixis, Inc. (EXEL) trades at 13.3x forward P/E versus 22.8x for Puma Biotechnology, Inc. — 9.5x cheaper on a one-year earnings basis.
07Which pays a better dividend — PBYI or EXEL?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is PBYI or EXEL better for a retirement portfolio?
For long-horizon retirement investors, Exelixis, Inc. (EXEL) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.63), +1110% 10Y return). Both have compounded well over 10 years (EXEL: +1110%, PBYI: -87.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between PBYI and EXEL?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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