PLRZ
Polyrizon Ltd.
Biotechnology
Market Cap$59M
5Y Perf.-95.9%
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Stock Comparison
PLRZ vs SIGA vs AGEN vs NVAX
Revenue, margins, valuation, and 5-year total return — side by side.
SIGA
SIGA Technologies, Inc.
Drug Manufacturers - Specialty & Generic
Market Cap$339M
5Y Perf.-34.5%
AGEN
Agenus Inc.
Biotechnology
Market Cap$132M
5Y Perf.-10.7%
NVAX
Novavax, Inc.
Biotechnology
Market Cap$1.50B
5Y Perf.-4.0%
PLRZ vs SIGA vs AGEN vs NVAX — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | PLRZ | SIGA | AGEN | NVAX |
|---|---|---|---|---|
| Industry | Biotechnology | Drug Manufacturers - Specialty & Generic | Biotechnology | Biotechnology |
| Market Cap | $59M | $339M | $132M | $1.50B |
| Revenue (TTM) | $0.00 | $94M | $114M | $596M |
| Net Income (TTM) | $-958K | $-4.04T | $115K | $-88M |
| Gross Margin | — | 61.8% | 35.7% | 84.6% |
| Operating Margin | — | 27.7% | -17.7% | -11.2% |
| Forward P/E | 28.3x | 2.8x | 1.8x | 3.6x |
| Total Debt | $0.00 | $595K | $10M | $249M |
| Cash & Equiv. | $3M | $155M | $3M | $241M |
PLRZ vs SIGA vs AGEN vs NVAX — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
PLRZ
SIGA
AGEN
NVAX
| Stock | Oct 24 | May 26 | Return |
|---|---|---|---|
| Polyrizon Ltd. (PLRZ) | 100 | 4.1 | -95.9% |
| SIGA Technologies, … (SIGA) | 100 | 65.5 | -34.5% |
| Agenus Inc. (AGEN) | 100 | 89.3 | -10.7% |
| Novavax, Inc. (NVAX) | 100 | 96.0 | -4.0% |
Price return only. Dividends and distributions are not included.
Quick Verdict: PLRZ vs SIGA vs AGEN vs NVAX
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: AGEN leads in 3 of 7 categories, making it the strongest pick for valuation and capital efficiency and profitability and margin quality. Novavax, Inc. is the stronger pick specifically for growth and revenue expansion and recent price momentum and sentiment. PLRZ and SIGA also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
PLRZ
Polyrizon Ltd.
The Defensive Pick
PLRZ is the clearest fit if your priority is sleep-well-at-night and defensive.
- Lower volatility, beta 0.66, current ratio 10.16x
- Beta 0.66, current ratio 10.16x
- Beta 0.66 vs AGEN's 2.72
Best for: sleep-well-at-night and defensive
SIGA
SIGA Technologies, Inc.
The Income Pick
SIGA is the clearest fit if your priority is income & stability and long-term compounding.
- Dividend streak 4 yrs, beta 1.15, yield 12.7%
- 7.6% 10Y total return vs NVAX's -90.4%
- 12.7% yield; 4-year raise streak; the other 3 pay no meaningful dividend
Best for: income & stability and long-term compounding
AGEN
Agenus Inc.
The Value Play
AGEN carries the broadest edge in this set and is the clearest fit for value and quality.
- Lower P/E (1.8x vs 3.6x)
- 0.1% margin vs SIGA's -43K%
- 0.1% ROA vs NVAX's -7.4%
Best for: value and quality
NVAX
Novavax, Inc.
The Growth Play
NVAX is the #2 pick in this set and the best alternative if growth exposure is your priority.
- Rev growth 64.7%, EPS growth 306.5%, 3Y rev CAGR -11.1%
- 64.7% revenue growth vs PLRZ's -7.5%
- +55.1% vs PLRZ's -91.3%
Best for: growth exposure
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | NVAX | 64.7% revenue growth vs PLRZ's -7.5% |
| Value | AGEN | Lower P/E (1.8x vs 3.6x) |
| Quality / Margins | AGEN | 0.1% margin vs SIGA's -43K% |
| Stability / Safety | PLRZ | Beta 0.66 vs AGEN's 2.72 |
| Dividends | SIGA | 12.7% yield; 4-year raise streak; the other 3 pay no meaningful dividend |
| Momentum (1Y) | NVAX | +55.1% vs PLRZ's -91.3% |
| Efficiency (ROA) | AGEN | 0.1% ROA vs NVAX's -7.4% |
PLRZ vs SIGA vs AGEN vs NVAX — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2025
FY 2025
FY 2025
PLRZ vs SIGA vs AGEN vs NVAX — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLAGENLAGGINGPLRZ
Who Leads Where
AGEN leads in 3 of 6 categories
NVAX leads 1 • SIGA leads 1 • PLRZ leads 0 • 1 tied
Explore the data ↓PLRZPolyrizon Ltd.
0leads
NVAXNovavax, Inc.
1leads
SIGASIGA Technologies, In…
1leads
AGENAgenus Inc.
3leads
6 Total Categories
CATEGORYLEADERvs SIGAvs NVAXMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
AGEN3/6
Valuation MetricsMultiples, price ratios, and targets
AGEN3/5
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
AGEN3/8
Total Returns1Y, 3Y, 5Y total returns with dividends
NVAX4/6
Risk & VolatilityBeta, volatility, and downside exposure
Tied
—
Analyst OutlookRatings, price targets, and dividends
SIGA1/1
Income & Cash Flow (Last 12 Months)
AGEN leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
NVAX and PLRZ operate at a comparable scale, with $596M and $0 in trailing revenue. AGEN is the more profitable business, keeping 0.1% of every revenue dollar as net income compared to SIGA's -43117.4%. On growth, AGEN holds the edge at +27.5% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | PLRZPolyrizon Ltd. | SIGASIGA Technologies… | AGENAgenus Inc. | NVAXNovavax, Inc. |
|---|---|---|---|---|
| RevenueTrailing 12 months | $0 | $94M | $114M | $596M |
| EBITDAEarnings before interest/tax | $120,688 | $26M | -$10M | -$47M |
| Net IncomeAfter-tax profit | -$957,656 | -$4.04T | $115,000 | -$88M |
| Free Cash FlowCash after capex | -$812,228 | $33M | -$159M | -$96M |
| Gross MarginGross profit ÷ Revenue | — | +61.8% | +35.7% | +84.6% |
| Operating MarginEBIT ÷ Revenue | — | +27.7% | -17.7% | -11.2% |
| Net MarginNet income ÷ Revenue | — | -43117.4% | +0.1% | -14.7% |
| FCF MarginFCF ÷ Revenue | — | +35.2% | -139.1% | -16.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | -11.3% | +27.5% | -79.1% |
| EPS Growth (YoY)Latest quarter vs prior year | +56.2% | — | +85.3% | -102.0% |
AGEN leads this category, winning 3 of 6 comparable metrics.
Valuation Metrics
AGEN leads this category, winning 3 of 5 comparable metrics.
Valuation Metrics
At 3.6x trailing earnings, NVAX trades at a 87% valuation discount to PLRZ's 28.3x P/E. On an enterprise value basis, NVAX's 2.6x EV/EBITDA is more attractive than SIGA's 7.6x.
| Metric | PLRZPolyrizon Ltd. | SIGASIGA Technologies… | AGENAgenus Inc. | NVAXNovavax, Inc. |
|---|---|---|---|---|
| Market CapShares × price | $59M | $339M | $132M | $1.5B |
| Enterprise ValueMkt cap + debt − cash | $57M | $185M | $140M | $1.5B |
| Trailing P/EPrice ÷ TTM EPS | 28.28x | 14.33x | -1102.94x | 3.63x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 2.78x | 1.79x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | 7.60x | — | 2.56x |
| Price / SalesMarket cap ÷ Revenue | — | 3.58x | 1.16x | 1.34x |
| Price / BookPrice ÷ Book value/share | 8.00x | 1.70x | — | — |
| Price / FCFMarket cap ÷ FCF | — | 6.96x | — | — |
AGEN leads this category, winning 3 of 5 comparable metrics.
Profitability & Efficiency
AGEN leads this category, winning 3 of 8 comparable metrics.
Profitability & Efficiency
PLRZ delivers a -5.2% return on equity — every $100 of shareholder capital generates $-5 in annual profit, vs $-11 for SIGA. On the Piotroski fundamental quality scale (0–9), AGEN scores 6/9 vs PLRZ's 3/9, reflecting solid financial health.
| Metric | PLRZPolyrizon Ltd. | SIGASIGA Technologies… | AGENAgenus Inc. | NVAXNovavax, Inc. |
|---|---|---|---|---|
| ROE (TTM)Return on equity | -5.2% | -10.7% | — | — |
| ROA (TTM)Return on assets | -5.1% | -7.4% | +0.1% | -7.4% |
| ROICReturn on invested capital | -65.4% | +33.7% | — | — |
| ROCEReturn on capital employed | -48.7% | +11.3% | — | +100.4% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 5 | 6 | 5 |
| Debt / EquityFinancial leverage | — | 0.00x | — | — |
| Net DebtTotal debt minus cash | -$3M | -$154M | $7M | $8M |
| Cash & Equiv.Liquid assets | $3M | $155M | $3M | $241M |
| Total DebtShort + long-term debt | $0 | $595,169 | $10M | $249M |
| Interest CoverageEBIT ÷ Interest expense | -0.30x | — | 1.11x | -5.10x |
AGEN leads this category, winning 3 of 8 comparable metrics.
Total Returns (Dividends Reinvested)
NVAX leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in SIGA five years ago would be worth $10,136 today (with dividends reinvested), compared to $365 for PLRZ. Over the past 12 months, NVAX leads with a +55.1% total return vs PLRZ's -91.3%. The 3-year compound annual growth rate (CAGR) favors NVAX at 7.4% vs PLRZ's -66.8% — a key indicator of consistent wealth creation.
| Metric | PLRZPolyrizon Ltd. | SIGASIGA Technologies… | AGENAgenus Inc. | NVAXNovavax, Inc. |
|---|---|---|---|---|
| YTD ReturnYear-to-date | +10.9% | -15.0% | +16.1% | +29.5% |
| 1-Year ReturnPast 12 months | -91.3% | +1.5% | +27.1% | +55.1% |
| 3-Year ReturnCumulative with dividends | -96.4% | +22.2% | -88.2% | +23.9% |
| 5-Year ReturnCumulative with dividends | -96.4% | +1.4% | -93.9% | -94.8% |
| 10-Year ReturnCumulative with dividends | -96.4% | +764.0% | -94.3% | -90.4% |
| CAGR (3Y)Annualised 3-year return | -66.8% | +6.9% | -51.0% | +7.4% |
NVAX leads this category, winning 4 of 6 comparable metrics.
Risk & Volatility
Evenly matched — PLRZ and NVAX each lead in 1 of 2 comparable metrics.
Risk & Volatility
PLRZ is the less volatile stock with a 0.66 beta — it tends to amplify market swings less than AGEN's 2.72 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. NVAX currently trades 77.1% from its 52-week high vs PLRZ's 6.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | PLRZPolyrizon Ltd. | SIGASIGA Technologies… | AGENAgenus Inc. | NVAXNovavax, Inc. |
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.66x | 1.15x | 2.72x | 2.11x |
| 52-Week HighHighest price in past year | $211.25 | $9.62 | $7.34 | $11.97 |
| 52-Week LowLowest price in past year | $0.55 | $4.29 | $2.71 | $5.80 |
| % of 52W HighCurrent price vs 52-week peak | +6.7% | +49.2% | +51.1% | +77.1% |
| RSI (14)Momentum oscillator 0–100 | 52.5 | 47.0 | 48.8 | 64.4 |
| Avg Volume (50D)Average daily shares traded | 42K | 688K | 814K | 4.4M |
Evenly matched — PLRZ and NVAX each lead in 1 of 2 comparable metrics.
Analyst Outlook
SIGA leads this category, winning 1 of 1 comparable metric.
Analyst Outlook
Analyst consensus: SIGA as "Buy", AGEN as "Buy", NVAX as "Buy". Consensus price targets imply 95.5% upside for AGEN (target: $7) vs 95.0% for NVAX (target: $18). SIGA is the only dividend payer here at 12.73% yield — a key consideration for income-focused portfolios.
| Metric | PLRZPolyrizon Ltd. | SIGASIGA Technologies… | AGENAgenus Inc. | NVAXNovavax, Inc. |
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | — | $7.33 | $18.00 |
| # AnalystsCovering analysts | — | 1 | 11 | 23 |
| Dividend YieldAnnual dividend ÷ price | — | +12.7% | — | — |
| Dividend StreakConsecutive years of raises | — | 4 | 1 | 1 |
| Dividend / ShareAnnual DPS | — | $0.60 | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | +0.1% | +0.3% |
SIGA leads this category, winning 1 of 1 comparable metric.
Key Takeaway
AGEN leads in 3 of 6 categories (Income & Cash Flow, Valuation Metrics). NVAX leads in 1 (Total Returns). 1 tied.
Best OverallAgenus Inc. (AGEN)Leads 3 of 6 categories
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PLRZ vs SIGA vs AGEN vs NVAX: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is PLRZ or SIGA or AGEN or NVAX a better buy right now?
For growth investors, Novavax, Inc.
(NVAX) is the stronger pick with 64. 7% revenue growth year-over-year, versus -31. 8% for SIGA Technologies, Inc. (SIGA). Novavax, Inc. (NVAX) offers the better valuation at 3. 6x trailing P/E, making it the more compelling value choice. Analysts rate SIGA Technologies, Inc. (SIGA) a "Buy" — based on 1 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — PLRZ or SIGA or AGEN or NVAX?
On trailing P/E, Novavax, Inc.
(NVAX) is the cheapest at 3. 6x versus Polyrizon Ltd. at 28. 3x. On forward P/E, Agenus Inc. is actually cheaper at 1. 8x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — PLRZ or SIGA or AGEN or NVAX?
Over the past 5 years, SIGA Technologies, Inc.
(SIGA) delivered a total return of +1. 4%, compared to -96. 4% for Polyrizon Ltd. (PLRZ). Over 10 years, the gap is even starker: SIGA returned +764. 0% versus PLRZ's -96. 4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — PLRZ or SIGA or AGEN or NVAX?
By beta (market sensitivity over 5 years), Polyrizon Ltd.
(PLRZ) is the lower-risk stock at 0. 66β versus Agenus Inc. 's 2. 72β — meaning AGEN is approximately 312% more volatile than PLRZ relative to the S&P 500.
05Which is growing faster — PLRZ or SIGA or AGEN or NVAX?
By revenue growth (latest reported year), Novavax, Inc.
(NVAX) is pulling ahead at 64. 7% versus -31. 8% for SIGA Technologies, Inc. (SIGA). On earnings-per-share growth, the picture is similar: Polyrizon Ltd. grew EPS 412. 5% year-over-year, compared to -60. 2% for SIGA Technologies, Inc.. Over a 3-year CAGR, AGEN leads at 5. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — PLRZ or SIGA or AGEN or NVAX?
Novavax, Inc.
(NVAX) is the more profitable company, earning 39. 2% net margin versus 0. 0% for Polyrizon Ltd. — meaning it keeps 39. 2% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: NVAX leads at 50. 1% versus -18. 0% for AGEN. At the gross margin level — before operating expenses — NVAX leads at 93. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is PLRZ or SIGA or AGEN or NVAX more undervalued right now?
On forward earnings alone, Agenus Inc.
(AGEN) trades at 1. 8x forward P/E versus 2. 8x for SIGA Technologies, Inc. — 1. 0x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for AGEN: 95. 5% to $7. 33.
08Which pays a better dividend — PLRZ or SIGA or AGEN or NVAX?
In this comparison, SIGA (12.
7% yield) pays a dividend. PLRZ, AGEN, NVAX do not pay a meaningful dividend and should not be held primarily for income.
09Is PLRZ or SIGA or AGEN or NVAX better for a retirement portfolio?
For long-horizon retirement investors, SIGA Technologies, Inc.
(SIGA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 15), 12. 7% yield, +764. 0% 10Y return). Agenus Inc. (AGEN) carries a higher beta of 2. 72 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SIGA: +764. 0%, AGEN: -94. 3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between PLRZ and SIGA and AGEN and NVAX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: PLRZ is a small-cap quality compounder stock; SIGA is a small-cap deep-value stock; AGEN is a small-cap quality compounder stock; NVAX is a small-cap high-growth stock. SIGA pays a dividend while PLRZ, AGEN, NVAX do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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