AXSM trades 57.1% below Wall Street's consensus target of $281.63.
Last 12 months price action with 12-month analyst target path
The base valuation assumes AXSM achieves its forward estimates and maintains a stable P/E multiple of historical averagesx. This scenario reflects the blended consensus of 27 Wall Street analysts, balancing both positive catalysts and macroeconomic headwinds over the next 12 months.
As of November 8, 2026, Axsome Therapeutics, Inc. (AXSM) has a Wall Street consensus price target of $281.63, based on estimates from 27 covering analysts. With the stock currently trading at $179.25, this represents a potential upside of +57.1%. The company has a market capitalization of $9.22B.
Analyst price targets range from a low of $246.00 to a high of $380.00, representing a 48% spread in expectations. The median target of $273.50 aligns closely with the consensus average.
The current analyst consensus rating is Buy, with 26 analysts rating the stock as a Buy or Strong Buy,1 rating it Hold, and 0 rating it Sell or Strong Sell. This overwhelmingly bullish sentiment suggests analysts see significant catalysts for upside ahead.
From a valuation perspective, AXSM trades at a trailing P/E of -48.7x. Analysts expect EPS to grow +27.4% over the next year.
| Company | Market Cap | Price | Target | Upside Potential | Rating | Fwd P/E | Analysts |
|---|---|---|---|---|---|---|---|
 INVAInnoviva, Inc. | $1.5B | $20.50 | $38.00 | +85.4% | Buy | 8.5x | 10 |
 SUPNSupernus Pharmaceuticals, Inc. | $2.5B | $42.38 | $57.60 | +35.9% | Buy | 16.5x | 14 |
 ACADACADIA Pharmaceuticals Inc. | $3.4B | $19.95 | $32.32 | +62.0% | Buy | 32.4x | 37 |
 INTRInter & Co, Inc. | $2.4B | $5.48 | $8.80 | +60.6% | Buy | 1.4x | 6 |
 PRAXPraxis Precision Medicines, Inc. | $8.2B | $295.51 | $603.83 | +104.3% | Buy | — | 18 |
 ALKSAlkermes plc | $7.0B | $41.75 | $58.83 | +40.9% | Buy | — | 29 |
 JAZZJazz Pharmaceuticals plc | $14.8B | $235.67 | $292.67 | +24.2% | Buy | 9.4x | 48 |
 NKTRNektar Therapeutics | $1.4B | $43.58 | $146.00 | +235.0% | Buy | — | 33 |
 PTCTPTC Therapeutics, Inc. | $5.3B | $63.46 | $106.00 | +67.0% | Buy | 49.9x | 26 |
 VNDAVanda Pharmaceuticals Inc. | $278M | $4.63 | $15.50 | +234.8% | Buy | — | 19 |
Quick answers to the most common questions about buying AXSM stock.
The consensus Wall Street price target for AXSM is $281.63, representing 57.1% upside from the current price of $179.25. With 27 analysts covering the stock, this strong upside suggests significant value not yet reflected in today's share price.
AXSM has a consensus rating of "Buy" based on 27 Wall Street analysts. The rating breakdown is predominantly bullish, with 26 Buy/Strong Buy ratings. The consensus 12-month price target of $281.63 implies 57.1% upside from current levels.
AXSM's current price is $179.25 with a consensus target of $281.63 (57.1% implied move). Analyst estimates suggest the stock is undervalued at current levels.
The most bullish Wall Street analyst has a price target of $380 for AXSM, while the most conservative target is $246. The consensus of $281.63 represents the median expectation. These targets typically reflect 12-month expectations.
AXSM is heavily covered by Wall Street, with 27 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 26 have Buy ratings, 1 recommend Hold, and 0 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
The 12-month AXSM stock forecast based on 27 Wall Street analysts shows a consensus price target of $281.63, with estimates ranging from $246 (bear case) to $380 (bull case). The median consensus rating is "Buy".
Wall Street analysts are very optimistic on AXSM, with a "Buy" consensus rating and $281.63 price target (57.1% upside). 26 of 27 analysts rate it Buy or Strong Buy. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
AXSM analyst price targets range from $246 to $380, a 48% moderate spread showing some variance in outlooks. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $281.63 consensus represents the middle ground.
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