Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in AGIO held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BlackRock, Inc. | 6.5M | $239.6M | +12.2% | 10.856% | 0.00% |
| 2 | FARALLON CAPITAL MANAGEMENT, L.L.C. | 5.9M | $219.6M | +4.1% | 9.950% | 1.01% |
| 3 | ARMISTICE CAPITAL, LLC | 5.2M | $193.3M | -11.9% | 8.761% | 2.37% |
| 4 | STATE STREET CORP | 3.5M | $131.1M | +5.0% | 5.942% | 0.00% |
| 5 | Lynx1 Capital Management LP | 3.4M | $126.5M | +30.5% | 5.732% | 9.21% |
| 6 | D. E. Shaw & Co., Inc. | 3.1M | $115.3M | +15.9% | 5.224% | 0.05% |
| 7 | VANGUARD PORTFOLIO MANAGEMENT LLC | 2.9M | $107.6M | +11.0% | 4.873% | 0.00% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2.7M | $99.5M | +1.9% | 4.510% | 0.00% |
| 9 | Erste Asset Management GmbH | 2.2M | $82.0M | -20.3% | 3.623% | 0.64% |
| 10 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 2.1M | $78.3M | +41.2% | 3.549% | 0.12% |
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.7M | $62.5M | +8.2% | 2.830% | 0.00% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 1.6M | $58.4M | +7.2% | 2.647% | 0.00% |
| 13 | ADAR1 Capital Management, LLC | 1.3M | $47.8M | +815.6% | 2.166% | 2.19% |
| 14 | BNP Paribas Asset Management Holding S.A. | 1.3M | $47.5M | -19.0% | 2.152% | 0.05% |
| 15 | DIMENSIONAL FUND ADVISORS LP | 1.2M | $46.3M | +8.4% | 2.100% | 0.01% |
| 16 | GOLDMAN SACHS GROUP INC | 1.2M | $42.7M | +40.8% | 1.935% | 0.00% |
| 17 | UBS Group AG | 986K | $36.6M | +643.8% | 1.658% | 0.00% |
| 18 | MORGAN STANLEY | 963K | $35.7M | -0.4% | 1.620% | 0.00% |
| 19 | CITADEL ADVISORS LLC | 913K | $33.9M | +18.7% | 1.536% | 0.00% |
| 20 | Nuveen, LLC | 874K | $32.4M | +20.9% | 1.469% | 0.01% |
| 21 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 811K | $30.1M | +223.6% | 1.363% | 0.01% |
| 22 | Foresite Capital Management VI LLC | 785K | $29.1M | +49.5% | 1.320% | 4.53% |
| 23 | JANE STREET GROUP, LLC | 747K | $27.7M | -11.3% | 1.255% | 0.00% |
| 24 | AQR CAPITAL MANAGEMENT LLC | 684K | $25.4M | +1779.5% | 1.151% | 0.01% |
| 25 | Parkman Healthcare Partners LLC | 669K | $24.8M | +65.8% | 1.125% | 2.54% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in AGIO — a direct measure of their conviction.
Filings activity in AGIO during Q2 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 237 | +2.2% | 117.35% | +3.33 pp | $2.53B | +18% |
| Q1 2026 | 232 | 2.1% | 114.02% | +23.66 pp | $2.14B | +24% |
| Q4 2025 | 237 | +6.3% | 90.36% | 25.61 pp | $1.72B | 33% |
| Q3 2025 | 223 | +5.7% | 115.97% | +9.27 pp | $2.55B | +34% |
| Q2 2025 | 211 | 1.4% | 106.70% | +3.32 pp | $1.90B | +18% |
| Q1 2025 | 214 | 2.7% | 103.38% | +23.89 pp | $1.61B | 8.4% |
| Q4 2024 | 220 | +10% | 79.49% | 18.64 pp | $1.76B | 23% |
| Q3 2024 | 200 | — | 98.13% | — | $2.28B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying AGIO stock.
Based on Q2 2026 13F filings, institutional ownership of Agios Pharmaceuticals, Inc. stands at 117.3%, held across 237 reporting institutions.
BlackRock, Inc. is the largest reported institutional holder of AGIO, with approximately 6,455,997 shares worth $0.24B as of Q2 2026.
Yes — 3 widely-followed marquee investors appear among the top 25 institutional holders of AGIO, including SUSQUEHANNA INTERNATIONAL GROUP, LLP, CITADEL ADVISORS LLC, JANE STREET GROUP, LLC.
Our composite Smart Money Score for AGIO is 72 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
33 institutions opened new positions in AGIO during Q2 2026, while 30 fully exited. 148 added to existing positions and 47 trimmed.
AGIO institutional ownership rose by 3.33 percentage points quarter-over-quarter, with a net change of +5 holders.
The top 10 institutions account for 55.1% of all reported 13F value in AGIO, and the top 25 account for 78.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Agios Pharmaceuticals, Inc. (AGIO) Institutional Ownership