The company has significantly improved its financial stability, reducing the debt-to-equity ratio from a peak of 84.26 in 2024Q3 to 1.18 as of 2026Q1.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 |
|---|
| Total Current Assets | 4.22B | 4.05B | 3.3B | 2.98B | 2.69B | 2.81B | 2.61B | 1.72B | 1.2B | 1.76B | 671.88M | 1.11B | 746.37M | 254.03M | 125.56M | 152.03M | 254.14M | 293.53M | 443.12M | 397.9M | 222.78M | 82.41M | 48.18M | 24.19M | 15.52M |
| Cash & Short-Term Investments | 3.01B | 2.91B | 2.69B | 2.44B | 2.19B | 2.44B | 1.87B | 1.54B | 1.08B | 1.69B | 626.8M | 1.08B | 696.69M | 245.87M | 122.81M | 146.4M | 233.13M | 281.4M | 430.39M | 389.95M | 217.26M | 80M | 46.05M | 23.19M | 15.48M |
| Cash Only | 1.71B | 1.66B | 966.43M | 812.69M | 866.39M | 819.98M | 496.58M | 547.18M | 420.15M | 645.36M | 193.62M | 180.9M | 75.18M | 53.17M | 51.41M | 70.23M | 74.6M | 137.47M | 191.79M | 105.16M | 127.95M | 15.76M | 20.27M | 23.19M | 15.48M |
| Short-Term Investments | 1.3B | 1.25B | 1.73B | 1.63B | 1.33B | 1.62B | 1.38B | 988.98M | 664.01M | 1.05B | 433.18M | 899.64M | 621.51M | 192.7M | 71.41M | 76.17M | 158.53M | 143.93M | 238.6M | 284.79M | 89.31M | 64.25M | 25.77M | 0 | 0 |
| Accounts Receivable | 883.96M | 777.57M | 405.31M | 327.79M | 237.96M | 198.57M | 602.41M | 43.01M | 18.76M | 34M | 23.33M | 8.3M | 39.94M | 4.25M | 104K | 1.47M | 3.45M | 6.04M | 4.19M | 5.03M | 3.83M | 755K | 1.17M | 0 | 0 |
| Days Sales Outstanding | 67.97 | 76.42 | 65.8 | 65.44 | 83.72 | 85.85 | 446.14 | 71.44 | 91.41 | 138.03 | 180.6 | 73.7 | 288.31 | 32.87 | 0.57 | 6.47 | 12.59 | 21.94 | 15.9 | 36.08 | 51.9 | 48.21 | 99.74 | - | - |
| Inventory | 84.03M | 82.72M | 78.51M | 89.15M | 128.96M | 86.36M | 75.2M | 56.35M | 24.07M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -226.24M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Inventory Outstanding | 34.96 | 44.59 | 88.62 | 104.82 | 278.83 | 224.93 | 351.67 | 820.65 | 4.88K | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Current Assets | 242.1M | 281.89M | 116.96M | 126.38M | 132.92M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.91M | 0 | 0 | 0 | 1.94M | 3.87M | 0 | 0 | 0 | 0 | 373K | 19K |
| Total Non-Current Assets | 910.24M | 915.67M | 944.7M | 847.18M | 854.11M | 834.73M | 792.28M | 679.27M | 374.11M | 229.99M | 590.93M | 281.12M | 333.23M | 166.5M | 161.96M | 129.89M | 139.13M | 187.85M | 111.55M | 95.89M | 17.22M | 15.93M | 17.93M | 10.99M | 592K |
| Property, Plant & Equipment | 707.56M | 708.06M | 693.93M | 725.79M | 738.63M | 733.63M | 706.51M | 646.38M | 320.66M | 181.9M | 114.57M | 27.81M | 21.74M | 16.45M | 19.8M | 14.64M | 18.29M | 18.32M | 19.19M | 13.81M | 12.17M | 10.58M | 11.69M | 4.76M | 526K |
| Fixed Asset Turnover | 6.12x | 5.25x | 3.24x | 2.52x | 1.40x | 1.15x | 0.70x | 0.34x | 0.23x | 0.49x | 0.41x | 1.48x | 2.33x | 2.87x | 3.37x | 5.65x | 5.47x | 5.49x | 5.01x | 3.69x | 2.21x | 0.54x | 0.37x | 0.04x | - |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 275K | 448K | 622K | 795K | 968K | 1.93M | 2.49M | 3.4M | 3.88M | 0 |
| Long-Term Investments | 53.87M | 0 | 0 | 0 | 0 | 0 | 0 | 14.82M | 44.83M | 13.92M | 324.8M | 251.84M | 279.82M | 150.05M | 142.16M | 114.41M | 120.39M | 160.35M | 83.9M | 74.78M | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Assets | 85.72M | 81.63M | 133.9M | 111.29M | 115.48M | 101.09M | 85.77M | 18.07M | 8.62M | 34.17M | 151.56M | 1.47M | 0 | 0 | 0 | 564K | 0 | 0 | 3.15M | 6.33M | 3.12M | 2.86M | 2.83M | 2.36M | 66K |
| Total Assets | 5.13B | 4.97B | 4.24B | 3.83B | 3.55B | 3.64B | 3.41B | 2.4B | 1.57B | 1.99B | 1.26B | 1.39B | 1.08B | 420.53M | 287.52M | 281.92M | 393.26M | 481.38M | 554.68M | 493.79M | 240.01M | 98.35M | 66.11M | 35.18M | 16.11M |
| Asset Turnover | 0.88x | 0.75x | 0.53x | 0.48x | 0.29x | 0.23x | 0.14x | 0.09x | 0.05x | 0.05x | 0.04x | 0.03x | 0.05x | 0.11x | 0.23x | 0.29x | 0.25x | 0.21x | 0.17x | 0.10x | 0.11x | 0.06x | 0.06x | 0.01x | - |
| Asset Growth % | 68.12% | 17.13% | 10.71% | 7.99% | -2.66% | 6.93% | 42.25% | 52.09% | -21.05% | 57.96% | -8.92% | 28.43% | 156.72% | 46.26% | 1.99% | -28.31% | -18.31% | -13.21% | 12.33% | 105.74% | 144.04% | 48.77% | 87.89% | 118.38% | - |
| Total Current Liabilities | 1.35B | 1.47B | 1.19B | 967.79M | 767.91M | 695.71M | 585.27M | 352.59M | 179.49M | 144.25M | 131.7M | 62.1M | 95.33M | 53.86M | 48.34M | 80.99M | 102.05M | 110.73M | 99.45M | 83.48M | 22.93M | 18.48M | 6.58M | 3.84M | 2.67M |
| Accounts Payable | 126.63M | 115.72M | 88.42M | 55.52M | 98.09M | 73.43M | 51.97M | 49.88M | 59.71M | 28.36M | 54.47M | 16.79M | 15.11M | 5.9M | 4.42M | 5.8M | 9.31M | 12.49M | 2.59M | 3.83M | 4.08M | 1.98M | 910K | 1.51M | 674K |
| Days Payables Outstanding | 51.51 | 62.37 | 99.8 | 65.28 | 212.09 | 191.24 | 243.01 | 726.5 | 12.09K | 774.26 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Short-Term Debt | 45.66M | 0 | 113.02M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.79M | 3.22M | 1.88M | 790K | 558K | 0 |
| Deferred Revenue (Current) | 25.68M | 4.84M | 55.48M | 102.75M | 42.1M | 149.48M | 127.21M | 77.82M | 3.5M | 41.7M | 33.54M | 15.35M | 23.87M | 32.7M | 31.42M | 62.37M | 81.62M | 82.77M | 79.86M | 59.25M | 11.14M | 10.73M | 1M | 333K | 0 |
| Other Current Liabilities | 1.17B | 477.26M | 214.4M | 177.16M | 170.98M | 130.66M | 110.75M | 68.3M | 40.87M | 35.81M | 15.27M | 12.32M | 40.03M | 5.93M | 950K | 484K | 0 | 0 | 1.56M | 1.39M | 0 | 0 | 0 | 0 | 0 |
| Current Ratio | 3.13x | 2.76x | 2.78x | 3.08x | 3.51x | 4.04x | 4.47x | 4.87x | 6.69x | 12.23x | 5.10x | 17.80x | 7.83x | 4.72x | 2.60x | 1.88x | 2.49x | 2.65x | 4.46x | 4.77x | 9.72x | 4.46x | 7.33x | 6.29x | 5.81x |
| Quick Ratio | 3.06x | 2.71x | 2.71x | 2.99x | 3.34x | 3.91x | 4.34x | 4.71x | 6.56x | 12.23x | 5.10x | 17.80x | 7.83x | 4.72x | 2.60x | 1.88x | 4.71x | 2.65x | 4.46x | 4.77x | 9.72x | 4.46x | 7.33x | 6.29x | 5.81x |
| Cash Conversion Cycle | 51.43 | 58.63 | 54.62 | 104.98 | 150.46 | 119.54 | 554.8 | 165.58 | -7.13K | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Total Non-Current Liabilities | 2.7B | 2.71B | 2.99B | 3.08B | 2.94B | 2.36B | 1.81B | 603.85M | 93.34M | 84.05M | 210.89M | 59.7M | 47.99M | 96.32M | 105.12M | 82.93M | 132.99M | 192.69M | 253.1M | 211.15M | 15.91M | 18.09M | 13.39M | 58.05M | 18.08M |
| Long-Term Debt | 1.23B | 1.01B | 2.36B | 1.02B | 1.02B | 675.7M | 191.28M | 0 | 30M | 30M | 150M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.96M | 5.92M | 5.52M | 6.41M | 1.3M | 0 |
| Capital Lease Obligations | 672.95M | 225.09M | 229.54M | 243.1M | 261.34M | 281.35M | 293.04M | 276.13M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 1.48B | 1.48B | 398.11M | 1.63B | 1.46B | 1.25B | 1.1B | 9.33M | 62.88M | 10.97M | 11.5M | 6.73M | 5.01M | 2.92M | 4.25M | 4.44M | 3.01M | 2.8M | 2.98M | 4.12M | 9.99M | 12.57M | 6.98M | 56.74M | 18.08M |
| Total Liabilities | 4.05B | 4.18B | 4.17B | 4.05B | 3.7B | 3.06B | 2.39B | 956.44M | 272.84M | 228.3M | 342.59M | 121.8M | 143.33M | 150.18M | 153.47M | 163.92M | 235.03M | 303.42M | 352.55M | 294.62M | 38.83M | 36.57M | 19.96M | 61.89M | 20.76M |
| Total Debt | 1.27B | 1.28B | 2.74B | 1.31B | 1.32B | 997.59M | 521.19M | 303.82M | 30M | 30M | 150M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.76M | 9.14M | 7.39M | 7.2M | 1.86M | 0 |
| Net Debt | -437.72M | -378.86M | 1.78B | 492.7M | 453.85M | 177.62M | 24.61M | -243.35M | -390.15M | -615.36M | -43.62M | -1.28B | -881.93M | -53.17M | -51.41M | -70.23M | -74.6M | -137.47M | -191.79M | -98.4M | -118.82M | -8.36M | -13.07M | -21.33M | -15.48M |
| Debt / Equity | 1.18x | 1.62x | 40.89x | - | - | 1.70x | 0.51x | 0.21x | 0.02x | 0.02x | 0.16x | - | - | - | - | - | - | - | - | 0.03x | 0.05x | 0.12x | 0.16x | - | - |
| Debt / EBITDA | 1.88x | 2.29x | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | -0.65x | -0.68x | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Interest Coverage | 2.02x | 1.99x | -1.66x | -2.58x | -6.23x | -4.96x | -9.13x | - | - | - | - | - | - | - | - | - | - | - | -28.28x | -73.07x | - | - | - | - | - |
| Total Equity | 1.08B | 789.18M | 67.09M | -220.64M | -158.22M | 588.2M | 1.02B | 1.44B | 1.3B | 1.77B | 920.22M | 1.26B | 936.27M | 270.35M | 134.05M | 118M | 158.23M | 177.97M | 202.13M | 199.17M | 201.17M | 61.78M | 46.14M | -26.71M | -4.65M |
| Equity Growth % | 10801.4% | 1076.33% | 130.41% | -39.45% | -126.9% | -42.12% | -29.36% | 10.5% | -26.29% | 91.96% | -27.24% | 35.08% | 246.32% | 101.67% | 13.61% | -25.43% | -11.09% | -11.95% | 1.48% | -1% | 225.63% | 33.89% | 272.77% | -474.84% | - |
| Book Value per Share | 7.78 | 5.86 | 0.53 | -1.77 | -1.30 | 4.97 | 8.84 | 13.17 | 12.94 | 19.51 | 10.75 | 15.06 | 12.60 | 4.39 | 2.67 | 2.78 | 3.76 | 4.27 | 4.92 | 5.15 | 6.31 | 2.81 | 3.88 | -28.33 | -14.02 |
| Total Shareholders' Equity | 1.08B | 789.18M | 67.09M | -220.64M | -158.22M | 588.2M | 1.02B | 1.44B | 1.3B | 1.77B | 920.22M | 1.26B | 936.27M | 270.35M | 134.05M | 118M | 158.23M | 177.97M | 202.13M | 199.17M | 201.17M | 61.78M | 46.14M | -26.71M | -4.65M |
| Common Stock | 1.33M | 1.32M | 1.29M | 1.26M | 1.24M | 1.2M | 1.16M | 1.12M | 1.01M | 997K | 859K | 851K | 772K | 637K | 525K | 427K | 423K | 418K | 414K | 408K | 371K | 267K | 208K | 0 | 0 |
| Retained Earnings | -6.5B | -6.7B | -7.29B | -7.01B | -6.57B | -5.44B | -4.59B | -3.73B | -2.84B | -2.15B | -1.66B | -1.25B | -956.63M | -596.24M | -507.01M | -401M | -343.35M | -299.83M | -252.24M | -225.99M | -140.53M | -105.92M | -63.01M | -29.52M | -4.49M |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | -24.89M | -20.1M | -34.52M | -23.38M | -44.65M | -33.26M | -43.62M | -36.52M | -33.21M | -34.43M | -33.44M | 4.37M | 48.76M | 19.72M | 15.66M | -165K | 714K | 716K | 1.19M | 300K | 551K | -2.6M | -3.28M | -4.61M | -161K |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Debt refinancing and dilution
According to recent financial statements, Alnylam has successfully transitioned from a negative equity position of $220.6 million in 2023Q4 to a positive $1.1 billion in 2026Q1, signaling a fundamental improvement in the company's financial health as commercial product sales begin to outpace historical R&D-driven losses.
The shift from negative to positive equity suggests that the company is successfully retaining earnings or managing capital raises effectively to support its commercial expansion. This trajectory implies a reduced reliance on external financing to sustain operations, which should provide more flexibility for future pipeline investments.
As reported in quarterly filings, Alnylam's debt-to-equity ratio has improved significantly from a peak of 84.26 in 2024Q3 to 1.18 in 2026Q1, reflecting a deliberate effort to deleverage the balance sheet as the company's commercial revenue base matures and provides more stable cash flow coverage.
While the absolute debt level remains near $1.3 billion, the dramatic reduction in the D/E ratio indicates that the company is successfully growing its equity base faster than it is accumulating new liabilities. Investors should monitor whether this leverage remains manageable as the company scales its primary care pipeline, which may require additional capital expenditures.
Based on the company's reported figures, Alnylam maintained a cash position of $1.7 billion in 2026Q1, providing a current ratio of 3.13, which suggests a robust liquidity buffer to navigate the high-cost clinical development phases of its expanding cardiovascular and primary care therapeutic programs.
The current ratio of 3.13 indicates that the company possesses sufficient short-term assets to cover its immediate obligations, reducing the risk of liquidity-driven distress. This liquidity position appears adequate to support ongoing commercialization efforts while providing a cushion against potential volatility in milestone-based revenue streams.
Analysis of recent SEC filings reveals that while the company has achieved positive equity, the persistent accumulation of retained losses totaling $6.5 billion as of 2026Q1 underscores the long-term capital intensity required to build the current siRNA platform and commercial infrastructure.
The substantial negative retained earnings balance serves as a reminder of the significant historical investment required to reach commercial viability. Future equity quality will likely depend on the company's ability to generate consistent net income to offset these accumulated deficits and minimize the need for further dilutive equity offerings.
Quick answers to the most common questions about buying ALNY stock.
As of 2025, Alnylam Pharmaceuticals, Inc. (ALNY) had total assets of $4.97B including $4.05B in current assets.
Alnylam Pharmaceuticals, Inc. (ALNY) carries total debt of $1.28B, offset by $2.91B in cash and short-term investments. Comparing total debt to cash helps evaluate the company's debt burden and net leverage.
Alnylam Pharmaceuticals, Inc. (ALNY) has total shareholders' equity (book value) of $789.2M ($5.86 book value per share). Book value represents the net worth of the company belonging to common stock holders.
Alnylam Pharmaceuticals, Inc. (ALNY) reported a current ratio of 2.76x. A current ratio above 1.0x indicates that the company has more current assets than current liabilities, suggesting sufficient short-term liquidity.