Operating cash flow remains volatile, moving from -$167.4M in 2026Q1 to $120.6M in 2026Q3 with a 27.0% free cash flow margin, and the single positive quarter appears heavily dependent on a $163.1M working capital inflow seen in 2025Q3 and similar swings.
Madrigal Pharmaceuticals, Inc. (MDGL) cash flow statement — 23-year operating, investing & financing cash flows
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 |
|---|
| Cash from Operations | -157.01M | -189.55M | -455.57M | -324.23M | -224.86M | -183.92M | -157.56M | -41.62M | -25.51M | -22.32M | -17.61M | -71.44M | -78.92M | -77.41M | -54.13M | -47.3M | -38.2M | -26.81M | -37.94M | 27.22M | -52.98M | -61.88M | -33.8M | -23.61M |
| Operating CF Margin % | - | -19.78% | -252.91% | - | - | - | - | - | - | - | - | - | - | - | - | -623.68% | -258.05% | -18.59% | -1450.82% | 3663.8% | - | - | -19534.68% | -1810.74% |
| Operating CF Growth % | 84.47% | 58.39% | -40.51% | -44.19% | -22.26% | -16.73% | -278.53% | -63.19% | -14.29% | -26.75% | 75.35% | 9.48% | -1.96% | -43% | -14.45% | -23.83% | -42.48% | 29.33% | -239.37% | 151.38% | 14.38% | -83.11% | -43.13% | - |
| Net Income | -155.46M | -288.28M | -465.89M | -373.63M | -295.35M | -241.85M | -202.24M | -83.95M | -32.81M | -31.15M | -26.39M | -68.67M | -86.16M | -90.19M | -62.79M | -47.38M | -37.47M | 79.09M | -92.62M | -63.49M | -57.27M | -68.86M | -45.93M | -27.88M |
| Depreciation & Amortization | 1.55M | 1.51M | 1.1M | 527K | 467K | 405K | 471K | 112K | 96K | 77K | 156 | 662K | 673K | 516K | 738K | 1.46M | 1.93M | 2.46M | 2.72M | 3.35M | 3.65M | 2.46M | 1.55M | 1.01M |
| Stock-Based Compensation | 108.34M | 98.13M | 79.88M | 49.73M | 31.63M | 26.87M | 20.73M | 22.76M | 13.49M | 3.25M | 8.68M | 4.3M | 7.43M | 6.03M | 3.32M | 3.35M | 4.05M | 4.58M | 7.57M | 5.42M | 4.79M | 0 | 0 | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | -7.32M | -21.83M | 0 | 0 | 0 | 0 | 0 | 0 | -6.03M | 0 | 0 | 0 | 0 | -7.57M | -5.42M | -4.79M | 0 | 0 | 0 |
| Other Non-Cash Items | 97.57M | 7.59M | 1.69M | 2.41M | 797K | 7.32M | 21.83M | 0 | 13.12M | 2.49M | 1.21M | 3.48M | 3.12K | 6.03M | 0 | 0 | 0 | 0 | 7.57M | 5.42M | 4.79M | 4.26M | 3.21M | 2.39M |
| Working Capital Changes | -209.01M | -8.5M | -72.34M | -3.28M | 37.6M | 30.65M | 23.48M | 19.45M | -6.28M | 5.51M | -1.11M | -7.74M | -868K | 6.24M | 4.59M | -4.74M | -6.71M | -112.94M | 44.39M | 81.95M | -4.16M | 266K | 7.38M | 866K |
| Change in Receivables | -114.11M | -80.65M | -53.82M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.33M | 38.82K | -40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | -60.53M | -36.98M | -34.07M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -44.72M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 16.81M | 5.28M | 15.56M | 4.21M | 2.45M | 20.36M | -161K | -1.31M | 558K | 917K | -128.06K | -1.84M | -3.45M | 928K | 2.19M | 1.54M | -2.03M | 626K | 840K | -144K | -729K | 0 | 0 | 0 |
| Cash from Investing | 347.76M | 32.32M | -274.39M | -502.52M | 206.69M | -5.05M | 159.78M | 30.71M | -380.08M | -22.01M | 21.99M | 20M | -8.84M | -24.65M | -9.94M | 9.33M | -19.8M | 21.05M | -23.69M | 10.79M | 23.57M | 39.18M | -43.81M | -40.4M |
| Capital Expenditures | -11.64M | -467K | -1.46M | -1.48M | -217K | -209K | -334K | -172K | -22K | -125K | -3.08K | -58K | -144K | -769K | -505K | -690K | -136K | -454K | -2.18M | -2.35M | -1.58M | -4.88M | -1.59M | -769K |
| CapEx % of Revenue | 0.82% | 0.05% | 0.81% | - | - | - | - | - | - | - | - | - | - | - | - | 9.1% | 0.92% | 0.31% | 83.52% | 316.29% | - | - | 921.39% | 58.97% |
| Acquisitions | 0 | 0 | 0 | 0 | -3K | 787K | 1.92M | 0 | -3.67M | 0 | 5.85M | 0 | 8.8K | 0 | 9.9K | 0 | 19.8K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -2.9M | -8.97M | 19.09M | 0 | 3K | -787K | -1.92M | 0 | 3.67M | -21.88K | 780.01K | 0 | -8.8K | 0 | -9.9K | 0 | -19.8K | 0 | 0 | 0 | 0 | 0 | 0 | 500K |
| Cash from Financing | 24.36M | 255.98M | 735.06M | 595.12M | 313.45M | 171.24M | 5.09M | 235K | 314.33M | 173.81M | 14.45M | 40.39M | 85.3M | 69.04M | 115.52M | 36.74M | 45.16M | -2.13M | -1.91M | 43.88M | 39.29M | 3.78M | 84.28M | 71.12M |
| Debt Issued (Net) | -983K | 217.93M | 0 | 65M | 50M | 0 | 0 | 0 | 0 | 0 | 8.5M | 3.3M | -9.49M | 10.87M | -4.25M | 1.42M | 13.17M | -2.18M | -1.91M | -2.62M | -2.09M | -1.1M | -153K | -70K |
| Equity Issued (Net) | 25.34M | 38.05M | 397.49M | 260.19M | 255.38M | 170.21M | 4.42M | 0 | 311.82M | 173.81M | 5.95M | 6 | 94.79M | 58.17M | 119.76M | 35.31M | 31.99M | 50K | 1K | 44.51M | 39.96M | 134K | 83.3M | 71.19M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1.86M | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -32K | 0 | 0 | 0 | 0 | -290K | 0 | 0 | 0 | 0 |
| Other Financing | 0 | 0 | 337.57M | 269.93M | 8.07M | 1.03M | 667K | 235K | 2.51M | 0 | -82 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.99M | 3.27M | 4.75M | 1.13M | 0 |
| Net Change in Cash | 214.75M | 98.76M | 5.1M | -231.63M | 295.28M | -17.73M | 7.31M | -10.68M | -91.25M | 129.48M | 18.84M | -11.06M | -2.47M | -33.02M | 51.44M | -1.24M | -12.85M | -7.89M | -63.53M | 81.89M | 9.88M | -18.93M | 6.67M | 7.11M |
| Free Cash Flow | -168.65M | -190.02M | -457.03M | -325.71M | -225.07M | -184.13M | -157.9M | -41.8M | -25.53M | -22.44M | -17.61M | -71.5M | -79.07M | -78.18M | -54.64M | -47.99M | -38.34M | -27.26M | -40.12M | 24.87M | -54.56M | -66.77M | -35.39M | -24.38M |
| FCF Margin % | -11.81% | -19.83% | -253.72% | - | - | - | - | - | - | - | - | - | - | - | - | -632.78% | -258.97% | -18.9% | -1534.34% | 3347.51% | - | - | -20456.07% | -1869.71% |
| FCF Growth % | -4.34% | 58.42% | -40.32% | -44.71% | -22.24% | -16.61% | -277.78% | -63.72% | -13.76% | -27.43% | 75.37% | 9.57% | -1.14% | -43.08% | -13.86% | -25.19% | -40.61% | 32.05% | -261.32% | 145.58% | 18.27% | -88.66% | -45.15% | - |
| FCF per Share | -5.56 | -8.47 | -21.48 | -17.43 | -13.13 | -11.14 | -10.22 | -2.71 | -1.73 | -1.83 | -3.38 | -418.11 | -28.10 | -38.55 | -32.20 | -35.60 | -33.25 | -27.97 | -41.63 | 26.81 | -85.78 | -105.01 | -66.22 | -39.05 |
| FCF Conversion (FCF/Net Income) | 1.08x | 0.66x | 0.98x | 0.87x | 0.76x | 0.76x | 0.78x | 0.50x | 0.78x | 0.72x | 0.67x | 10.44x | 0.92x | 0.86x | 0.86x | 1.00x | 1.02x | -0.34x | 0.41x | -0.43x | 0.93x | 0.90x | 0.74x | 0.85x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quick answers to the most common questions about buying MDGL stock.
Madrigal Pharmaceuticals, Inc. (MDGL) generated $-189.6M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Madrigal Pharmaceuticals, Inc. (MDGL) reported negative free cash flow of $190.0M in 2025, indicating capital requirements exceeded cash from operations.
Madrigal Pharmaceuticals, Inc. (MDGL) spent $0.5M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
Key Metrics
Top Statement Risk
Cash flow reliance on working capital swings
Metrics are mathematically derived from official filings.
Operating Cash Flow Tracks Earnings Erratically
According to the reported cash flow statements, MDGL's operating cash flow to net income ratio swung from 2.17 in 2026Q3 to -0.40 in 2026Q2, indicating that reported earnings are not consistently converting into operating cash.
The quarterly OCF/NI ratio has oscillated between negative and above 2.0 across the ten-quarter window, which makes the single-quarter relationship between profit and cash hard to rely on. The 2026Q3 ratio of 2.17 appears driven largely by a $26.4M working capital inflow rather than sustained earnings power, suggesting investors should separate the timing effect from underlying conversion. Until several consecutive quarters show OCF tracking net income more consistently, the earnings quality warrants further investigation.
Free Cash Flow Turns Positive Only Episodically
Based on reported figures, MDGL's free cash flow margin reached 27.0% in 2026Q3 after negative margins of -55.0% in 2026Q1 and -41.4% in 2025Q4, pointing to a volatile rather than steady trajectory.
Free cash flow has been negative in most quarters of the period, and the sole strong positive reading coincides with a large working capital inflow, which may not repeat. Capital expenditure remains minimal at roughly 1% of revenue, so the FCF swings are driven by operating and working capital dynamics rather than investment spending. The data suggests the company has not yet demonstrated a self-sustaining cash generation pattern.
Working Capital Swings Dominate Cash Results
As reported in the financial statements, MDGL's working capital change moved from a $163.1M inflow in 2025Q3 to a $105.9M outflow in 2026Q1, a swing large enough to dominate quarterly operating cash flow.
The magnitude of working capital movements relative to reported net income indicates that receivables, inventory, or payables timing is the primary driver of quarterly cash results. Large inflows followed by large outflows suggest the cash profile may reflect collection timing rather than durable operating improvement. Investors should monitor whether these swings normalize as the commercial base matures.
Cumulative Cash Lags Reported Earnings
Based on the ten reported quarters, MDGL's cumulative operating cash flow remains negative while stock-based compensation of roughly $35M per quarter represents a material non-cash add-back in recent periods.
Summing operating cash flow across the window shows persistent cash consumption, which contrasts with the narrowing operating losses described in the income statement. Stock-based compensation appears to be a meaningful component of the gap between reported economics and cash generation, and it may warrant scrutiny when assessing true cash burn. The divergence suggests reported profitability should be viewed cautiously until cash generation catches up.
Positive Quarter May Not Be Durable
The strongest challenge to a cash-positive thesis is that MDGL's only robust operating cash quarter, 2026Q3, followed a working capital inflow and was preceded by two quarters of negative operating cash flow.
A single strong quarter driven by working capital release does not establish a sustainable cash generation pattern, and the prior quarters show substantial cash consumption. If the 2026Q3 inflow reverses, the company could return to negative free cash flow despite improving operating income. This interpretation rests on reported figures and does not account for management's forward guidance or any financing arrangements not present in the supplied data.