Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in MIST held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 6.3M | $7.5M | +152.6% | 7.371% | 0.07% |
| 2 | Propel Bio Management, LLC | 4.1M | $5.1M | 0.0% | 4.795% | 3.20% |
| 3 | TWO SIGMA INVESTMENTS, LP | 2.3M | $2.8M | +53.0% | 2.698% | 0.00% |
| 4 | GOLDMAN SACHS GROUP INC | 2.0M | $2.4M | — | 2.329% | 0.00% |
| 5 | MARSHALL WACE, LLP | 1.9M | $2.3M | +17.4% | 2.264% | 0.00% |
| 6 | MILLENNIUM MANAGEMENT LLC | 1.5M | $1.8M | +283.6% | 1.798% | 0.00% |
| 7 | Simplify Asset Management Inc. | 1.5M | $1.8M | 0.0% | 1.754% | 0.03% |
| 8 | Point72 Asset Management, L.P. | 1.1M | $1.3M | +125.1% | 1.264% | 0.00% |
| 9 | BALYASNY ASSET MANAGEMENT LLC | 851K | $1.0M | — | 0.991% | 0.00% |
| 10 | Lion Point Capital, LP | 820K | $976K | +8.6% | 0.955% | 5.83% |
| 11 | TORONTO DOMINION BANK | 750K | $893K | 0.0% | 0.873% | 0.00% |
| 12 | MORGAN STANLEY | 724K | $862K | -7.4% | 0.843% | 0.00% |
| 13 | Boxer Capital Management, LLC | 667K | $793K | 0.0% | 0.776% | 0.10% |
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 629K | $749K | -49.6% | 0.733% | 0.00% |
| 15 | UBS Group AG | 495K | $589K | +0.6% | 0.576% | 0.00% |
| 16 | CITADEL ADVISORS LLC | 347K | $413K | — | 0.404% | 0.00% |
| 17 | Squarepoint Ops LLC | 337K | $401K | +35.1% | 0.392% | 0.00% |
| 18 | Seven Fleet Capital Management LP | 333K | $397K | — | 0.388% | 0.13% |
| 19 | GUARDIAN WEALTH ADVISORS, LLC / NC | 280K | $333K | +6.5% | 0.326% | 0.02% |
| 20 | Aptus Capital Advisors, LLC | 280K | $333K | +6.5% | 0.326% | 0.00% |
| 21 | LPL Financial LLC | 193K | $230K | +35.7% | 0.225% | 0.00% |
| 22 | BNP PARIBAS ARBITRAGE, SA | 177K | $210K | -20.5% | 0.205% | 0.00% |
| 23 | BOOTHBAY FUND MANAGEMENT, LLC | 169K | $201K | — | 0.196% | 0.01% |
| 24 | SIMPLEX TRADING, LLC | 149K | $178K | — | 0.174% | 0.01% |
| 25 | Quadrature Capital Ltd | 149K | $177K | — | 0.174% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in MIST — a direct measure of their conviction.
Filings activity in MIST during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 83 | +9.2% | 32.54% | 16.22 pp | $35M | 33% |
| Q4 2025 | 76 | +27% | 48.76% | 13.97 pp | $53M | 22% |
| Q3 2025 | 60 | +40% | 62.73% | +41.69 pp | $68M | +198% |
| Q2 2025 | 43 | 2.3% | 21.04% | +12.22 pp | $23M | +138% |
| Q1 2025 | 44 | 4.3% | 8.82% | 42.96 pp | $10M | 83% |
| Q4 2024 | 46 | +9.5% | 51.78% | +14.77 pp | $56M | +40% |
| Q3 2024 | 42 | +7.7% | 37.01% | 58.66 pp | $40M | 61% |
| Q2 2024 | 39 | — | 95.67% | — | $104M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying MIST stock.
Based on Q1 2026 13F filings, institutional ownership of Milestone Pharmaceuticals Inc. stands at 32.5%, held across 83 reporting institutions.
RTW INVESTMENTS, LP is the largest reported institutional holder of MIST, with approximately 6,331,001 shares worth $0.01B as of Q1 2026.
Yes — 5 widely-followed marquee investors appear among the top 25 institutional holders of MIST, including TWO SIGMA INVESTMENTS, LP, MILLENNIUM MANAGEMENT LLC, Point72 Asset Management, L.P., SUSQUEHANNA INTERNATIONAL GROUP, LLP, CITADEL ADVISORS LLC.
Our composite Smart Money Score for MIST is 60 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
22 institutions opened new positions in MIST during Q1 2026, while 15 fully exited. 6 added to existing positions and 55 trimmed.
MIST institutional ownership fell by 16.22 percentage points quarter-over-quarter, with a net change of +7 holders.
The top 10 institutions account for 76.0% of all reported 13F value in MIST, and the top 25 account for 95.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Milestone Pharmaceuticals Inc. (MIST) Institutional Ownership