Puma Biotechnology, Inc. (PBYI) P/E Ratio History
Historical price-to-earnings valuation from 2022 to 2025
Loading P/E history...
Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of March 1, 2026, Puma Biotechnology, Inc. (PBYI) trades at a price-to-earnings ratio of 9.3x, with a stock price of $5.70 and trailing twelve-month earnings per share of $0.60.
The current P/E is 96% below its 5-year average of 228.6x. Over the past five years, PBYI's P/E has ranged from a low of 3.5x to a high of 2820.0x, placing the current valuation at the 38th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.7x, PBYI trades at a 61% discount to its sector peers. The sector includes 224 companies with P/E ratios ranging from 0.0x to 184.4x.
Relative to the broader market, PBYI trades at a notable discount to the S&P 500 median P/E of 26.2x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our PBYI DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
Peer Comparison
P/E metrics vs. Oncology Therapeutics Developers peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
INCYIncyte Corporation | $20B | 15.8 | - | +4173%Best |
GMABGenmab A/S | $18B | 15.4 | 0.53 | +84% |
EXELExelixis, Inc. | $12B | 15.8 | 0.31Best | +58% |
INBXInhibrx Biosciences, Inc. | $1B | 0.6Lowest | - | +2377% |
BBOTBridgeBio Oncology Therapeutics Inc. | $794M | 21.8 | - | - |
PBYIPuma Biotechnology, Inc. | $287M | 9.3 | - | -2% |
CHRSCoherus Oncology, Inc. | $194M | 6.7 | - | +110% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
Historical P/E Data
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Date | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2025 Q4 | Wed Dec 31 2025 00:00:00 GM | $5.95 | $0.61 | 9.8x | -96% |
| FY2025 Q3 | $5.31 | $0.74 | 7.2x | -97% | |
| FY2025 Q2 | Mon Jun 30 2025 00:00:00 GM | $3.43 | $0.98 | 3.5x | -98% |
| FY2025 Q1 | Mon Mar 31 2025 00:00:00 GM | $2.96 | $0.77 | 3.9x | -98% |
| FY2024 Q4 | $3.05 | $0.61 | 5.0x | -98% | |
| FY2024 Q3 | Mon Sep 30 2024 00:00:00 GM | $2.55 | $0.48 | 5.4x | -98% |
| FY2024 Q2 | Sun Jun 30 2024 00:00:00 GM | $3.26 | $0.19 | 17.5x | -92% |
| FY2024 Q1 | Sun Mar 31 2024 00:00:00 GM | $5.30 | $0.33 | 16.3x | -93% |
| FY2023 Q4 | Sun Dec 31 2023 00:00:00 GM | $4.33 | $0.45 | 9.5x | -96% |
| FY2023 Q3 | Sat Sep 30 2023 00:00:00 GM | $2.63 | $0.07 | 35.2x | -85% |
| FY2023 Q1 | Fri Mar 31 2023 00:00:00 GM | $3.09 | $0.11 | 27.6x | -88% |
| FY2022 Q4 | Sat Dec 31 2022 00:00:00 GM | $4.23 | $0.00 | 2820.0x | +1134% |
Average P/E for displayed period: 228.6x
See PBYI's True Return
Price is only half the story. See total return with reinvested dividends.
Launch CalculatorIs PBYI Undervalued?
See our Bear / Base / Bull DCF models and intrinsic value estimates.
View ValuationCompare PBYI vs AGIO
See how PBYI stacks up against sector leader Agios Pharmaceuticals, Inc..
Start ComparisonFrequently Asked Questions
Is PBYI stock overvalued or undervalued?
PBYI trades at 9.3x P/E, below its 5-year average of 228.6x. At the 38th percentile of historical range, the stock is priced at a discount to its own history.
How does PBYI's valuation compare to peers?
Puma Biotechnology, Inc. P/E of 9.3x compares to sector median of 23.7x. The discount suggests lower growth expectations or higher risk.
What is PBYI's PEG ratio?
PBYI PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2022-2025.