Last 45 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -30.94 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 34.75 | 24.59 | 31.26 | 31.67 | 20.74 | 25.53 | 20.61 | 24.11 | 21.54 | 25.09 | 28.08 | 14.74 | 12.20 |
| — | -3.7% | +51.7% | +31.3% | -3.7% | +1.8% | -26.6% | +63.6% | +76.6% | +13.8% | -39.8% | -79.9% | +111.5% | |
| P/B Ratio | 44.97 | 48.10 | 51.47 | 43.67 | — | 20.48 | 20.96 | 21.00 | 13.96 | 42.32 | 16.03 | 6.72 | 5.14 |
| — | +134.8% | +145.6% | +107.9% | — | -51.6% | +30.7% | +212.6% | +171.3% | +819.3% | +158.5% | +50.0% | +381.2% | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Rhythm Pharmaceuticals, Inc.'s operating margin was -87.1% in Q1 2026, down 4.9 pp QoQ and up 56.6 pp YoY. The trailing four-quarter average of -91.3% lags the current quarter, suggesting the recent improvement is above-trend.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 89.7% | 88.1% | 91.6% | 89.3% | 88.6% | 88.8% | 90.9% | 88.5% | 89.9% | 89.2% | 86.7% | 89.3% | 88.4% |
| — | -0.8% | +0.7% | +0.9% | -1.4% | -0.4% | +4.9% | -0.9% | +1.7% | +1.8% | -1.9% | +1.0% | -7.8% | |
| Operating Margin | -101.2% | -87.1% | -82.2% | -102.6% | -93.4% | -143.7% | -98.6% | -132.0% | -139.2% | -538.7% | -170.3% | -195.3% | -242.5% |
| — | +39.4% | +16.7% | +22.2% | +32.9% | +73.3% | +42.1% | +32.4% | +42.6% | -17.6% | +64.5% | +78.7% | +51.3% | |
| Net Margin | -103.6% | -94.4% | -83.0% | -103.1% | -96.1% | -151.4% | -103.5% | -131.2% | -110.9% | -544.4% | -171.8% | -196.2% | -243.0% |
| — | +37.6% | +19.8% | +21.4% | +13.3% | +72.2% | +39.8% | +33.1% | +54.3% | -19.7% | +64.5% | +79.4% | +51.0% |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -129.5% | -43.3% | -33.0% | -77.3% | -61.7% | -30.2% | -27.3% | -26.3% | -26.8% | -122.2% | -22.7% | -23.3% | -23.2% |
| — | -43.4% | -20.9% | -194.1% | -130.5% | +75.3% | -20.4% | -13.0% | -15.2% | -466.9% | -45.5% | -35.7% | -11.4% | |
| ROA | -45.0% | -12.3% | -9.6% | -12.0% | -12.3% | -12.7% | -11.5% | -11.7% | -10.1% | -47.8% | -12.1% | -13.3% | -14.2% |
| — | +3.3% | +16.1% | -2.7% | -21.9% | +73.4% | +5.5% | +12.0% | +29.3% | -233.6% | -10.1% | -8.6% | +11.0% | |
| ROIC | -70.1% | -12.7% | -12.2% | -22.0% | -39.3% | -50.2% | -32.8% | -50.2% | -194.8% | -174.6% | -25.2% | -32.6% | -38.8% |
| — | +74.7% | +62.8% | +56.3% | +79.8% | +71.2% | -30.0% | -54.2% | -401.8% | -454.9% | +5.4% | -1.1% | -40.2% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has improved 26.2% YoY to 4.17x, strengthening the short-term liquidity position. Debt/Equity has risen for 3 consecutive quarters, indicating increasing financial leverage that investors should watch closely.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 1.77 | 1.85 | 1.77 | 1.01 | — | 0.02 | 0.02 | 0.03 | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 |
| — | +7314.1% | +7305.6% | +3744.7% | — | +42.4% | +222.4% | +261.9% | +159.1% | +115.8% | +0.9% | -2.5% | -23.3% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 4.41 | 4.17 | 4.41 | 4.75 | 2.79 | 3.30 | 3.24 | 3.49 | 6.53 | 4.35 | 5.58 | 6.57 | 6.16 |
| — | +26.2% | +36.1% | +36.1% | -57.3% | -24.1% | -42.0% | -46.9% | +6.1% | -37.0% | -37.2% | -40.0% | +10.1% | |
| Quick Ratio | 4.16 | 3.89 | 4.16 | 4.75 | 2.64 | 3.13 | 3.08 | 3.34 | 6.31 | 4.20 | 5.43 | 6.41 | 6.02 |
| — | +24.3% | +35.3% | +41.9% | -58.2% | -25.4% | -43.3% | -47.8% | +4.8% | -38.2% | -38.5% | -41.4% | +7.7% | |
| Interest Coverage | -8.52 | -11.43 | -9.30 | -10.13 | -6.96 | -8.14 | -6.96 | -7.39 | -5.90 | -28.67 | -8.11 | -12.91 | -13.14 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 45 years · Updated daily
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Rhythm Pharmaceuticals, Inc.'s current P/E is -30.9x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Rhythm Pharmaceuticals, Inc.'s current operating margin is -101.2%. Margins have been expanding over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Rhythm Pharmaceuticals, Inc.'s business trajectory between earnings reports.