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SION logoSionna Therapeutics, Inc. (SION) Earnings History

Annual and quarterly earnings data from 2022 to 2025

TTM Net Income
-$75M
Net Loss
TTM EPS
$-1.88
Diluted
YoY EPS Growth
-34.3%
Declining
Net Margin
N/A
Profitability
Operating MarginN/A
Gross MarginN/A
ROE-105.2%
ROA-29.4%
Highest Annual Net Income-$40M (2022)
Highest Quarterly EPS$-0.27 (Q4 2023)
Consecutive Profitable Years0 years
Q4 2025
Net Income-$20M
EPS$-0.46
QoQ Growth-0.8%Slow

Loading earnings history...

SION EPS Growth (CAGR)

Compound annual growth rate of diluted earnings per share

1-Year
N/A
N/M
3-Year
N/A
N/M
5-Year
N/A
N/M
10-Year
N/A
N/M

CAGR (Compound Annual Growth Rate) shows the annualized growth rate of EPS over the specified period. A higher CAGR indicates stronger earnings momentum.

SION Profitability Analysis

Margin trends over time

View revenue breakdown →
YearGross MarginOperating MarginNet Margin
2025---
2024---
2023---
2022---
Gross Margin = Gross Profit ÷ Revenue
Operating Margin = Operating Income ÷ Revenue
Net Margin = Net Income ÷ Revenue

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Sionna Therapeutics, Inc. (SION) Earnings Overview

As of May 8, 2026, Sionna Therapeutics, Inc. (SION) reported trailing twelve-month net income of -$75M, reflecting -34.3% year-over-year growth. The company earned $-1.88 per diluted share over the past four quarters.

Looking at the long-term picture, SION's historical earnings data spans multiple years. The company achieved its highest annual net income of -$40M in fiscal 2022.

Sionna Therapeutics, Inc. is currently reporting a net loss, though operating performance should be evaluated in the context of growth investments and industry dynamics View revenue history →

Compared to peers including VRTX ($4.34B net income, 32.7% margin), ABBV ($4.23B net income, 6.9% margin), PTCT (-$187M net income, 39.4% margin), SION has comparable earnings metrics. Compare SION vs VRTX →

SION Earnings vs Peers

Earnings metrics vs comparable public companies

CompanyTTM Net IncomeTTM EPSNet MarginROEYoY GrowthCompare
SION logoSIONCurrent
-$75M$-1.88--105.2%-34.3%—
VRTX logoVRTX
$4.3B$16.9332.7%22.5%+836.5%
ABBV logoABBV
$4.2B$2.386.9%6214.7%-0.8%
PTCT logoPTCT
-$187M$-2.2639.4%-+264.5%
RARE logoRARE
-$609M$-6.06-85.4%-607.5%+7.3%
KRYS logoKRYS
$225M$7.3852.6%18.9%+128.0%
Best in group
Lowest in group

SION Historical Earnings Data (2022–2025)

4 years
Fiscal Year Net Income YoY % Operating Income EPS (Diluted) Net Margin Op. Margin
2025-$75M-22.0%-$89M$-1.88--
2024-$62M-30.5%-$71M$-1.40--
2023-$47M-17.5%-$50M$-1.07--
2022-$40M--$41M$-0.91--

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Compare SION vs DBVT

Side-by-side business, growth, and profitability comparison vs DBV Technologies S.A..

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SION — Frequently Asked Questions

Quick answers to the most common questions about buying SION stock.

Is SION growing earnings?

SION EPS fell to $-1.88, with earnings declining -34.3%. This contrasts with the 5-year CAGR of N/A. TTM net income dropped to $-75M.

What are SION's profit margins?

Sionna Therapeutics, Inc. net margin is N/A, with operating margin at N/A. Below-average margins reflect competitive or cost pressures.

How consistent are SION's earnings?

SION earnings data spans 2022-2025. The declining earnings trend is -34.3% YoY. Historical data enables comparison across business cycles.

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SION Earnings Over Time (2022–2025)

Net income and EPS trends