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Sionna Therapeutics, Inc. (SION) Total Return Calculator with Dividends Reinvested

Sionna Therapeutics, Inc.

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The total return for Sionna Therapeutics, Inc. (SION) stock is +239.26% over the past 12 months. So far it's up 10.41% this year. The 5-year total return is +73.16%, meaning $10,000 invested in SION stock 5 years ago would be worth $17,316 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in SION 1 year ago, it would be worth $33,610 today — you'd have gained $23,610.

With Dividends Reinvested$33,610+236.10%

Price Only (No DRIP)$33,610+236.10%

Period2025-05-07 → 2026-05-06

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in SION

1Y$33,926+$23,926 (+239.3%)239.3% CAGR

3Y$17,316+$7,316 (+73.2%)20.1% CAGR

5Y$17,316+$7,316 (+73.2%)11.6% CAGR

10Y$17,316+$7,316 (+73.2%)5.6% CAGR

15Y$17,316+$7,316 (+73.2%)3.7% CAGR

20Y$17,316+$7,316 (+73.2%)2.8% CAGR

30Y$17,316+$7,316 (+73.2%)1.8% CAGR

Sionna Therapeutics, Inc. did not pay dividends during this period. Total return = price return.

Loading SION total return...

As of 2026-05-07

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	+10.41%	—	+10.41%	—	$11,041
1Y	+239.26%	239.26%	+239.26%	—	$33,926
3Y	+73.16%	20.08%	+73.16%	—	$17,316
5Y	+73.16%	11.61%	+73.16%	—	$17,316
10Y	+73.16%	5.64%	+73.16%	—	$17,316
15Y	+73.16%	3.73%	+73.16%	—	$17,316
20Y	+73.16%	2.78%	+73.16%	—	$17,316
30Y	+73.16%	1.85%	+73.16%	—	$17,316

Risk & Highlights

Best Year+64.56%2025

Max Drawdown-24.15%2025-06-10 → 2025-06-17 · Recovered 2025-07-02

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	-6.81%	-6.81%	—	+0.41%	-7.2pp
2025	+64.56%	+64.56%	—	+16.64%	+47.9pp

SION outperformed the S&P 500 by 207.94pp over the past year (+239.26% vs +31.32%).

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SION Peers' Total Return

Accurate peer set · 10 comparable names

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
SIONSionna Therapeutics, Inc.	$1.9B	+15.8%	+10.4%	+239.3%	—	+73.2%	+73.2%	+73.2%
VRTXVertex Pharmaceuticals Incorporated	$108.8B	-1.5%	-5.4%	-5.0%	—	+24.3%	+100.6%	+399.9%
ABBVAbbVie Inc.	$362.6B	-0.8%	-9.1%	+13.1%	+3.6pp	+52.0%	+102.8%	+306.7%
PTCTPTC Therapeutics, Inc.	$5.5B	-3.3%	-13.2%	+84.1%	—	+19.9%	+65.2%	+839.5%
RAREUltragenyx Pharmaceutical Inc.	$2.5B	+13.4%	+9.9%	-26.0%	—	-44.9%	-77.6%	-58.9%
KRYSKrystal Biotech, Inc.	$8.5B	+10.3%	+17.0%	+107.1%	—	+229.6%	+310.3%	+2615.2%
GILDGilead Sciences, Inc.	$169.8B	-2.7%	+12.8%	+42.5%	+3.3pp	+85.3%	+127.5%	+92.6%
ALNYAlnylam Pharmaceuticals, Inc.	$40.4B	-8.3%	-24.3%	+12.3%	—	+44.3%	+129.4%	+445.5%
IONSIonis Pharmaceuticals, Inc.	$12.7B	+3.4%	-3.5%	+141.2%	—	+118.4%	+105.9%	+126.0%
EDITEditas Medicine, Inc.	$311M	+16.7%	+54.9%	+138.7%	—	-67.0%	-90.8%	-89.5%
BEAMBeam Therapeutics Inc.	$3.3B	+33.4%	+19.1%	+102.2%	—	-3.0%	-53.9%	+72.4%

Compare:SION vs VRTX SION vs ABBV SION vs PTCT SION vs VRTX vs ABBV

About SION Dividend Returns

Sionna Therapeutics, Inc. (SION) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of SION over the past year?

Sionna Therapeutics, Inc. (SION) delivered a return of 239.26% over the past year. Since SION does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in SION be worth today?

A $10,000 investment in Sionna Therapeutics, Inc. one year ago would be worth $33,926 today, representing a gain of $23,926.

Q3Does SION pay dividends?

Sionna Therapeutics, Inc. (SION) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For SION, the total return equals the price-only return.

Q4Did SION beat the S&P 500?

Yes, Sionna Therapeutics, Inc. (SION) outperformed the S&P 500 by 207.94 percentage points over the past year. SION delivered a total return of 239.26%, compared to the S&P 500's 31.32%. This 207.94pp alpha means investors in SION earned more than a passive S&P 500 index fund.

Q5What is SION's worst drawdown?

Sionna Therapeutics, Inc. (SION) experienced a maximum drawdown of -24.15% over the past year, declining from its peak on 2025-06-10 to its trough on 2025-06-17. The stock recovered to its prior peak by 2025-07-02. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is SION's long-term total return over 10, 20, or 30 years?

Here are Sionna Therapeutics, Inc. (SION)'s long-term returns with dividends reinvested. Over 10 years, the total return is 73.2% (5.6% CAGR) — $10,000 would have grown to $17,316. Over 20 years: 73.2% total return (2.8% CAGR) — $10,000 → $17,316. Over 30 years: 73.2% total return (1.8% CAGR) — $10,000 → $17,316. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.