Sionna Therapeutics, Inc. (SION) Price Target Analysis
Updated Jun 26, 2026
Analyst Rating: Buy
Based on 7 analysts28.0% Below Target
SION trades 28.0% below Wall Street's consensus target of $54.00.
Current Price$42.18
Average Target$54.00
Target
Current
Low$50.00
Median$54.00
High$58.00
Analyst Target Range
Forward P/E—
PEG Ratio—
Implied Growth-35.3%
(Declining)
Analyst Spread14.8%
(High Agreement)
Price Forecast (1 Year)
Last 12 months price action with 12-month analyst target path
Consensus Scenario Assumptions
The base valuation assumes SION achieves its forward estimates and maintains a stable P/E multiple of historical averagesx. This scenario reflects the blended consensus of 7 Wall Street analysts, balancing both positive catalysts and macroeconomic headwinds over the next 12 months.
SION Price Target Analysis
Updated June 29, 2026As of June 29, 2026, Sionna Therapeutics, Inc. (SION) has a Wall Street consensus price target of $54.00, based on estimates from 7 covering analysts. With the stock currently trading at $42.18, this represents a potential upside of +28.0%. The company has a market capitalization of $1.90B.
Analyst price targets range from a low of $50.00 to a high of $58.00, representing a 15% spread in expectations. The median target of $54.00 aligns closely with the consensus average. The tight target dispersion indicates high conviction among analysts.
The current analyst consensus rating is Buy, with 5 analysts rating the stock as a Buy or Strong Buy,1 rating it Hold, and 1 rating it Sell or Strong Sell. This overwhelmingly bullish sentiment suggests analysts see significant catalysts for upside ahead.
From a valuation perspective, SION trades at a trailing P/E of -22.4x. Analysts expect EPS to grow -35.3% over the next year.
Investment Context: Price targets represent analyst expectations for the next 12 months and should be considered alongside your own research. Targets are based on analysts' assumptions about earnings growth, margins, and market conditions which may change. For sector-specific context, view other Healthcare stocks.
Analyst Sentiment Comparison
Industry Peer AnalysisAvg Peer Upside
+30.3%
Industry Consensus
Avg Forward P/E
45.2x
(Growth Premium)
Peers with Coverage
10 / 10
Active Analyst Tracking
| Company | Market Cap | Price | Target | Upside Potential | Rating | Fwd P/E | Analysts |
|---|---|---|---|---|---|---|---|
 VRTXVertex Pharmaceuticals Incorporated | $125.0B | $491.34 | $553.93 | +12.7% | Buy | 25.5x | 56 |
 ABBVAbbVie Inc. | $444.4B | $251.52 | $258.00 | +2.6% | Buy | 17.7x | 41 |
 PTCTPTC Therapeutics, Inc. | $7.0B | $84.43 | $95.83 | +13.5% | Buy | 95.3x | 26 |
 RAREUltragenyx Pharmaceutical Inc. | $3.0B | $30.77 | $48.36 | +57.2% | Buy | — | 33 |
 KRYSKrystal Biotech, Inc. | $11.0B | $372.25 | $336.40 | -9.6% | Buy | 48.5x | 17 |
 GILDGilead Sciences, Inc. | $158.8B | $127.88 | $161.81 | +26.5% | Buy | — | 58 |
 ALNYAlnylam Pharmaceuticals, Inc. | $38.9B | $291.37 | $454.27 | +55.9% | Buy | 38.9x | 52 |
 IONSIonis Pharmaceuticals, Inc. | $13.4B | $81.18 | $106.50 | +31.2% | Buy | — | 32 |
 EDITEditas Medicine, Inc. | $279M | $2.85 | $5.00 | +75.4% | Buy | — | 25 |
 BEAMBeam Therapeutics Inc. | $3.6B | $34.81 | $48.00 | +37.9% | Buy | — | 27 |
SION — Frequently Asked Questions
Quick answers to the most common questions about buying SION stock.
What is the SION stock price target for 2026?
The consensus Wall Street price target for SION is $54, representing 28.0% upside from the current price of $42.18. With 7 analysts covering the stock, this strong upside suggests significant value not yet reflected in today's share price.
Is SION a buy, sell, or hold?
SION has a consensus rating of "Buy" based on 7 Wall Street analysts. The rating breakdown is predominantly bullish, with 5 Buy/Strong Buy ratings. The consensus 12-month price target of $54 implies 28.0% upside from current levels.
Is SION stock overvalued or undervalued?
SION's current price is $42.18 with a consensus target of $54 (28.0% implied move). Analyst estimates suggest the stock is undervalued at current levels.
How high can SION stock go?
The most bullish Wall Street analyst has a price target of $58 for SION, while the most conservative target is $50. The consensus of $54 represents the median expectation. These targets typically reflect 12-month expectations.
How many analysts cover SION stock?
SION is moderately covered, with 7 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 5 have Buy ratings, 1 recommend Hold, and 1 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
What is the SION stock forecast?
The 12-month SION stock forecast based on 7 Wall Street analysts shows a consensus price target of $54, with estimates ranging from $50 (bear case) to $58 (bull case). The median consensus rating is "Buy".
Should I buy SION stock?
Wall Street analysts are very optimistic on SION, with a "Buy" consensus rating and $54 price target (28.0% upside). 5 of 7 analysts rate it Buy or Strong Buy. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
Why do SION price targets vary so much?
SION analyst price targets range from $50 to $58, a 15% tight range reflecting strong analyst consensus. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $54 consensus represents the middle ground.
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