The company's financial position has shifted toward higher leverage, with total debt reaching $346.5M by 2025Q4 and a D/E ratio of 5.36, while total equity has eroded to $41.6M as of 2026Q1.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|
| Total Current Assets | 471.18M | 528.08M | 603.06M | 580.88M | 489.79M | 448.4M | 298.86M | 62.33M | 83.35M | 133.44M | 108.51M | 88.01M | 12.44M | 14.54M | 735K | 4.39M |
| Cash & Short-Term Investments | 352.06M | 394.07M | 582.91M | 577.58M | 484.4M | 446.83M | 293.06M | 59.77M | 80.91M | 133.22M | 105.33M | 87.29M | 12.21M | 14.26M | 628K | 4.31M |
| Cash Only | 130.89M | 134.93M | 154.08M | 295.39M | 74.36M | 221.97M | 115.24M | 24.61M | 33.77M | 35.17M | 23.84M | 23.18M | 10.01M | 10.1M | 537K | 3.7M |
| Short-Term Investments | 221.17M | 259.14M | 428.83M | 282.19M | 410.04M | 224.87M | 177.82M | 35.17M | 47.14M | 94.81M | 81.49M | 64.11M | 2.2M | 4.16M | 91K | 613K |
| Accounts Receivable | 38.12M | 38M | 13.87M | 1.23M | 4.06M | 429K | 175K | 116K | 253K | 377K | 306K | 258K | 35K | 0 | 0 | 0 |
| Days Sales Outstanding | 58.38 | 80.47 | 213.81 | - | - | 1.12 | 42.11 | 27.91 | 60.87 | 65.28 | 91.55 | 150.19 | - | - | - | - |
| Inventory | 34.95M | 32.75M | 366K | 0 | 0 | 0 | 0 | 0 | 1.05M | -1.44M | 2.41M | 264K | 51K | 0 | 0 | 0 |
| Days Inventory Outstanding | 2.32K | 1.72K | 161.73 | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Current Assets | 46.05M | 63.26M | -2.02M | 63K | 117K | 265K | 456K | 2.06M | 1.79M | 1.29M | 615K | 996K | 150K | 50K | 83K | 77K |
| Total Non-Current Assets | 1.49M | 1.63M | 121.76M | 32M | 7.45M | 1.26M | 1.75M | 1.19M | 592K | 3.74M | 503K | 1.9M | 372K | 2.52M | 775K | 395K |
| Property, Plant & Equipment | 1.39M | 1.52M | 2.02M | 1.5M | 1.06M | 1.26M | 482K | 997K | 373K | 267K | 260K | 88K | 33K | 40K | 20K | 50K |
| Fixed Asset Turnover | 141.48x | 113.17x | 11.71x | - | - | 110.79x | 3.15x | 1.52x | 4.07x | 7.90x | 4.69x | 7.13x | - | - | - | - |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 82.88M | 0 | 119.52M | 29.83M | 5.47M | 0 | 0 | 115K | 0 | 3.25M | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Assets | 102K | 102K | 217K | 680K | 922K | 0 | 1.27M | 82K | 219K | 231K | 243K | 1.81M | 339K | 2.48M | 755K | 345K |
| Total Assets | 472.67M | 529.71M | 724.82M | 612.88M | 497.24M | 449.66M | 300.61M | 63.52M | 83.94M | 137.19M | 109.01M | 89.9M | 12.82M | 17.06M | 1.51M | 4.79M |
| Asset Turnover | 0.40x | 0.33x | 0.03x | - | - | 0.31x | 0.01x | 0.02x | 0.02x | 0.02x | 0.01x | 0.01x | - | - | - | - |
| Asset Growth % | 1.43% | -26.92% | 18.26% | 23.26% | 10.58% | 49.58% | 373.22% | -24.32% | -38.81% | 25.84% | 21.26% | 601.49% | -24.88% | 1029.87% | -68.45% | - |
| Total Current Liabilities | 86.17M | 120.12M | 103.55M | 58.1M | 29.07M | 20.68M | 18.87M | 18.37M | 16.11M | 15.8M | 10.37M | 4.85M | 10.35M | 2.73M | 25.1M | 13.41M |
| Accounts Payable | 10.84M | 16.58M | 11.63M | 9.96M | 4.35M | 5.67M | 3.51M | 6.18M | 1.44M | 2.23M | 2.38M | 1.45M | 354K | 1.08M | 776K | 810K |
| Days Payables Outstanding | 1.2K | 868.25 | 5.14K | - | - | - | - | - | - | - | - | - | - | - | - | 5.8K |
| Short-Term Debt | 0 | 472K | 12.12M | 0 | 0 | 0 | 2.29M | 0 | 0 | 0 | 0 | 0 | 6.45M | 0 | 21.34M | 10.68M |
| Deferred Revenue (Current) | 0 | 0 | 0 | 0 | 0 | 0 | 1.52M | 1.52M | 1.52M | 1.57M | 1.22M | 1.22M | 3.38M | 0 | 2.41M | 0 |
| Other Current Liabilities | 75.33M | 103.06M | 79.33M | 35.92M | 6.55M | 6.23M | 3.74M | 7.39M | 10.35M | 9.6M | 5.13M | 916K | 1.94M | 0 | 660K | 1.92M |
| Current Ratio | 5.47x | 4.40x | 5.82x | 10.00x | 16.85x | 21.68x | 15.84x | 3.39x | 5.18x | 8.45x | 10.47x | 18.16x | 1.20x | 5.33x | 0.03x | 0.33x |
| Quick Ratio | 5.06x | 4.12x | 5.82x | 10.00x | 16.85x | 21.68x | 15.84x | 3.39x | 5.11x | 8.54x | 10.24x | 18.10x | 1.20x | 5.33x | 0.03x | 0.33x |
| Cash Conversion Cycle | 1.17K | 927.45 | -4.76K | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Total Non-Current Liabilities | 258.7M | 344.96M | 333.14M | 588K | 722K | 20.61M | 29.55M | 13.56M | 14.79M | 17.07M | 14.51M | 18.36M | 8.19M | 2.48M | 5.69M | 10.44M |
| Long-Term Debt | 0 | 344.96M | 331.56M | 0 | 0 | 19.89M | 17.83M | 0 | 0 | 0 | 0 | 0 | 7.43M | 0 | 0 | 8.66M |
| Capital Lease Obligations | 3.57M | 1.05M | 1.58M | 588K | 722K | 711K | 101K | 419K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4K |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 258.7M | -1.05M | 0 | 0 | 0 | 0 | 1K | 5K | 136K | 310K | 288K | 2.92M | 751K | 2.48M | 5.69M | 1.77M |
| Total Liabilities | 344.87M | 465.08M | 436.69M | 58.68M | 29.79M | 41.29M | 48.42M | 31.93M | 30.89M | 32.87M | 24.87M | 23.2M | 18.53M | 5.21M | 30.8M | 23.84M |
| Total Debt | 0 | 346.48M | 345.74M | 1.64M | 1.16M | 20.97M | 20.54M | 897K | 0 | 0 | 0 | 0 | 13.88M | 0 | 21.34M | 19.34M |
| Net Debt | -130.89M | 211.55M | 191.66M | -293.76M | -73.19M | -201M | -94.71M | -23.71M | -33.77M | -35.17M | -23.84M | -23.18M | 3.88M | -10.1M | 20.81M | 15.64M |
| Debt / Equity | 0.00x | 5.36x | 1.20x | 0.00x | 0.00x | 0.05x | 0.08x | 0.03x | - | - | - | - | - | - | - | - |
| Debt / EBITDA | -0.00x | - | - | - | - | 0.80x | - | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | 0.60x | - | - | - | - | -7.65x | - | - | - | - | - | - | - | - | - | - |
| Interest Coverage | -2.31x | -7.45x | -63.67x | -1005.54x | -46.61x | 14.13x | -30.04x | - | -38.08x | -43.60x | -45.78x | -13.02x | - | - | - | -5.59x |
| Total Equity | 41.62M | 64.63M | 288.12M | 554.2M | 467.45M | 408.37M | 252.19M | 31.6M | 53.05M | 104.32M | 84.14M | 66.7M | -5.72M | 11.85M | -29.29M | -19.05M |
| Equity Growth % | -290.47% | -77.57% | -48.01% | 18.56% | 14.47% | 61.93% | 698.06% | -40.43% | -49.15% | 23.98% | 26.15% | 1266.86% | -148.24% | 140.46% | -53.7% | - |
| Book Value per Share | 0.47 | 0.75 | 3.37 | 7.88 | 7.69 | 7.84 | 6.11 | 1.04 | 2.09 | 4.97 | 5.76 | 11.93 | -0.60 | 1.48 | -0.42 | -0.00 |
| Total Shareholders' Equity | 41.62M | 64.63M | 288.12M | 554.2M | 467.45M | 408.37M | 252.19M | 31.6M | 53.05M | 104.32M | 84.14M | 66.7M | -5.72M | 11.85M | -29.29M | -19.05M |
| Common Stock | 9K | 9K | 9K | 8K | 7K | 6K | 5K | 3K | 2K | 2K | 2K | 1K | 1K | 1K | 0 | 0 |
| Retained Earnings | -1.55B | -1.51B | -1.22B | -902.4M | -693.04M | -543.7M | -568.63M | -495.47M | -439.42M | -366.11M | -305.29M | -259.68M | -159.8M | -135.71M | -79.05M | -68.9M |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | 0 | 452K | 163K | 218K | -806K | 45K | -4K | 0 | -25K | -143K | 56K | 28K | -185K | -170K | -238K | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Binary Regulatory Approval Risk
As reported in financial statements, SNDX's total equity has contracted from $554.2M in 2023Q4 to $41.6M by 2026Q1, reflecting a persistent depletion of capital as the company funds intensive late-stage clinical development programs without the support of recurring commercial product revenue to stabilize its financial position.
The consistent decline in equity highlights the high cost of maintaining a pre-commercial pipeline, where retained earnings have deepened to -$1.5B. This trajectory suggests that the company is increasingly reliant on external financing or milestone-based inflows to prevent further balance sheet deterioration.
Based on reported figures, SNDX's debt profile shifted significantly in late 2025, with total debt rising to $346.5M by 2025Q4, resulting in a D/E ratio of 5.36, which marks a departure from the company's historical reliance on equity-based funding for its clinical operations.
The sudden introduction of debt onto the balance sheet warrants close monitoring, as it introduces interest obligations that may constrain cash flow during the critical pre-commercial launch phase. Investors should consider whether this leverage is a strategic bridge to commercialization or a sign of tightening access to equity markets.
According to quarterly data, the current ratio has compressed from 10.00 in 2023Q4 to 5.47 in 2026Q1, indicating that while the company maintains a nominal liquidity buffer, the absolute cash position of $130.9M is being rapidly consumed by ongoing R&D and administrative expenses.
The reduction in the current ratio suggests that the company's ability to cover short-term obligations is narrowing as cash reserves are deployed into clinical trial execution. This trend implies that the company may face a liquidity crunch if regulatory milestones are delayed or if commercial launch costs exceed current projections.
As indicated by the financial data, the company's equity base has been severely eroded by cumulative losses, with retained earnings reaching -$1.5B, a trend that underscores the significant capital intensity required to advance the Menin-MLL inhibitor pipeline toward potential regulatory approval and eventual commercialization.
The erosion of equity suggests that shareholders are bearing the full brunt of the company's pre-commercial development costs. Future equity quality will likely depend on the company's ability to transition from milestone-based funding to sustainable product revenue, as continued losses will further diminish the book value of the firm.
Quick answers to the most common questions about buying SNDX stock.
As of 2025, Syndax Pharmaceuticals, Inc. (SNDX) had total assets of $529.7M including $528.1M in current assets.
Syndax Pharmaceuticals, Inc. (SNDX) carries total debt of $346.5M, offset by $394.1M in cash and short-term investments. Comparing total debt to cash helps evaluate the company's debt burden and net leverage.
Syndax Pharmaceuticals, Inc. (SNDX) has total shareholders' equity (book value) of $64.6M ($0.75 book value per share). Book value represents the net worth of the company belonging to common stock holders.
Syndax Pharmaceuticals, Inc. (SNDX) reported a current ratio of 4.40x. A current ratio above 1.0x indicates that the company has more current assets than current liabilities, suggesting sufficient short-term liquidity.