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SNDXSyndax Pharmaceuticals, Inc.
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SNDX logoSyndax Pharmaceuticals, Inc.(SNDX)Earnings, Financials & Key Ratios

SNDX•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutSyndax Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidates are SNDX-5613, which is in phase 1/2 clinical trial targeting the binding interaction of Menin with the mixed lineage leukemia 1 protein for the treatment of MLL-rearranged (MLLr) and nucleophosmin 1 mutant acute myeloid leukemia (NPM1c AML); and SNDX-6352 or axatilimab, a monoclonal antibody that blocks the colony stimulating factor 1, or CSF-1 receptor for the treatment of patients with chronic graft versus host disease (cGVHD). The company is also developing Entinostat. It also has collaborative research and development agreement with National Cancer Institute; a clinical trial agreement with Eastern Cooperative Oncology Group; and a license agreement with Kyowa Hakko Kirin Co., Ltd. Syndax Pharmaceuticals, Inc. was incorporated in 2005 and is headquartered in Waltham, Massachusetts.Massachusetts.Show more
  • Revenue$172M+627.8%
  • EBITDA-$273M+19.6%
  • Net Income-$285M+10.5%
  • EPS (Diluted)-3.29+11.8%
  • Gross Margin95.96%-0.6%
  • EBITDA Margin-158.44%+89.0%
  • Operating Margin-158.45%+89.0%
  • Net Margin-165.6%+87.7%
  • ROE-161.82%-113.8%

SNDX Key Insights

Syndax Pharmaceuticals, Inc. (SNDX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y sales CAGR of 157.7%

✗Weaknesses

  • ✗High debt to equity ratio of 5.4x
  • ✗Profits declining 31.3% over 5 years
  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Expensive at 25.5x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SNDX Price & Volume

Syndax Pharmaceuticals, Inc. (SNDX) stock price & volume — 10-year historical chart

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SNDX Growth Metrics

Syndax Pharmaceuticals, Inc. (SNDX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years75.35%
5 Years157.68%
3 Years-
TTM396.72%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM26.56%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM40.31%

Return on Capital

10 Years-51.19%
5 Years-36.43%
3 Years-51.9%
Last Year-52.98%

SNDX Recent Earnings

Syndax Pharmaceuticals, Inc. (SNDX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 2/12 qtrs (29%)
Q2 2026Latest
Apr 30, 2026
Metric
Actual
Est
EPS
$0.48+18.6%
$0.59
Rev
$65M-7.0%
$70M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$0.78-33.6%
$0.58
Rev
$69M+6.9%
$64M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$0.70+5.4%
$0.74
Rev
$46M-27.6%
$63M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$0.83+17.0%
$1.00
Rev
$38M-16.9%
$46M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 30, 2026
$0.48vs $0.59+18.6%
$65Mvs $70M-7.0%
Q1 2026Feb 26, 2026
$0.78vs $0.58-33.6%
$69Mvs $64M+6.9%
Q4 2025Nov 3, 2025
$0.70vs $0.74+5.4%
$46Mvs $63M-27.6%
Q3 2025Aug 4, 2025
$0.83vs $1.00+17.0%
$38Mvs $46M-16.9%
Based on last 12 quarters of dataView full earnings history →

SNDX Peer Comparison

Syndax Pharmaceuticals, Inc. (SNDX) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor7.38B90.43-24.51-16.72%-6.12%-25.02%0.05
IMVT logoIMVTImmunovant, Inc.Direct Competitor7.26B35.34-12.76-68.16%0.00
RVMD logoRVMDRevolution Medicines, Inc.Direct Competitor34.65B162.99-27.39-83.22%0.10
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor8.15B53.2219.2187.32%65.95%87.36%0.40
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
VERA logoVERAVera Therapeutics, Inc.Direct Competitor2.52B35.09-7.53-74.86%0.13
IOVA logoIOVAIovance Biotherapeutics, Inc.Product Competitor1.4B3.91-3.5960.6%-123.9%-50.17%0.07
FATE logoFATEFate Therapeutics, Inc.Product Competitor243.61M2.09-1.82-51.24%-20.57%-58.89%0.38

Compare SNDX vs Peers

Syndax Pharmaceuticals, Inc. (SNDX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs KYMR

Most directly comparable listed peer for SNDX.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SNDX against a more recognizable public peer.

Peer Set

Compare Top 5

vs KYMR, IMVT, RVMD, TGTX

SNDX Income Statement

Syndax Pharmaceuticals, Inc. (SNDX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
2.11M1.52M1.52M1.52M139.71M0023.68M172.35M217.17M
Revenue Growth %
72.79%-28.04%0%0%9109.56%-100%--627.84%396.72%
Cost of Goods Sold
0000000826K6.97M4.44M
COGS % of Revenue
-------3.49%4.04%-
Gross Profit
2.11M▲ 0%
1.52M▼ 28.0%
1.52M▲ 0.0%
1.52M▲ 0.0%
139.71M▲ 9109.6%
0▼ 100.0%
0▲ 0%
22.85M▲ 0%
165.38M▲ 623.6%
212.73M▲ 0%
Gross Margin %
100%100%100%100%100%--96.51%95.96%97.96%
Gross Profit Growth %
72.79%-28.04%0%0%9109.56%-100%--623.65%-
Operating Expenses
64.06M77.39M59.06M72.94M113.49M151.76M229.95M362.53M438.47M436.26M
OpEx % of Revenue
3038.99%5101.71%3892.95%4808.17%81.23%--1530.94%254.4%-
Selling, General & Admin
15.86M17.29M16.06M22.5M25.24M33.26M66.92M120.88M179.68M176.24M
SG&A % of Revenue
752.42%1139.55%1058.8%1483.52%18.07%--510.47%104.25%-
Research & Development
48.2M60.11M42.99M50.44M88.25M118.5M163.03M241.65M258.78M255.99M
R&D % of Revenue
2286.57%3962.16%2834.15%3324.65%63.17%--1020.47%150.15%-
Other Operating Expenses
0000000001000K
Operating Income
-61.95M▲ 0%
-75.88M▼ 22.5%
-57.54M▲ 24.2%
-71.42M▼ 24.1%
26.22M▲ 136.7%
-151.76M▼ 678.8%
-229.95M▼ 51.5%
-339.67M▼ 47.7%
-273.08M▲ 19.6%
-223.53M▲ 0%
Operating Margin %
-2938.99%-5001.71%-3792.95%-4708.17%18.77%---1434.43%-158.45%-102.93%
Operating Income Growth %
-41.56%-22.47%24.17%-24.13%136.71%-678.78%-51.53%-47.71%19.6%-
EBITDA
-61.88M-75.8M-57.09M-70.91M26.26M-151.72M-229.94M-339.66M-273.08M-218.16M
EBITDA Margin %
-2935.39%-4996.57%-3763.22%-4674.23%18.8%---1434.39%-158.44%-100.45%
EBITDA Growth %
-41.67%-22.5%24.68%-24.21%137.04%-677.71%-51.55%-47.72%19.6%33.44%
D&A (Non-Cash Add-back)
76K78K451K515K43K33K12K8K6K6K
EBIT
-61.95M-73.96M-56.05M-70.8M26.82M-146.2M-209.15M-313.83M-251.64M-131.73M
Net Interest Income
1.42M1.94M1.57M-1.52M-1.5M2.73M20.95M21.16M-11.05M-48.03M
Interest Income
001.57M841K403K5.87M21.16M26.09M22.73M24.38M
Interest Expense
1.42M1.94M02.36M1.9M3.14M208K4.93M33.78M57M
Other Income/Expense
1.15M1.92M1.49M-1.74M-1.29M2.42M20.59M20.91M-12.34M-19.72M
Pretax Income
-60.8M▲ 0%
-73.96M▼ 21.6%
-56.05M▲ 24.2%
-73.16M▼ 30.5%
24.93M▲ 134.1%
-149.34M▼ 699.1%
-209.36M▼ 40.2%
-318.76M▼ 52.3%
-285.42M▲ 10.5%
-243.25M▲ 0%
Pretax Margin %
-2884.35%-4875.48%-3694.59%-4822.54%17.84%---1346.11%-165.6%-112.01%
Income Tax
-76K000000000
Effective Tax Rate %
0.12%0%0%0%0%0%0%0%0%0%
Net Income
-60.8M▲ 0%
-73.96M▼ 21.6%
-55.95M▲ 24.3%
-73.07M▼ 30.6%
24.93M▲ 134.1%
-149.34M▼ 699.1%
-209.36M▼ 40.2%
-318.76M▼ 52.3%
-285.42M▲ 10.5%
-243.25M▲ 0%
Net Margin %
-2884.35%-4875.48%-3688.53%-4816.68%17.84%---1346.11%-165.6%-112.01%
Net Income Growth %
-36.72%-21.64%24.35%-30.59%134.11%-699.13%-40.19%-52.25%10.46%26.56%
Net Income (Continuing)
-60.8M-73.96M-56.05M-73.16M24.93M-149.34M-209.36M-318.76M-285.42M-243.25M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-2.90▲ 0%
-2.92▼ 0.7%
-1.84▲ 37.0%
-1.77▲ 3.8%
0.48▲ 127.1%
-2.46▼ 612.5%
-2.98▼ 21.1%
-3.73▼ 25.2%
-3.29▲ 11.8%
-▲ 0%
EPS Growth %
4.61%-0.69%36.99%3.8%127.12%-612.5%-21.14%-25.17%11.8%40.31%
EPS (Basic)
-2.90-2.92-1.84-1.770.48-2.46-2.98-3.73-3.29-
Diluted Shares Outstanding
21M25.37M30.49M41.31M52.06M60.76M70.37M85.62M86.63M0
Basic Shares Outstanding
21M25.37M30.49M41.31M52.06M60.76M70.37M85.62M86.63M0
Dividend Payout Ratio
----------

SNDX Balance Sheet

Syndax Pharmaceuticals, Inc. (SNDX) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
133.44M83.35M62.33M298.86M448.4M489.79M580.88M603.06M528.08M471.18M
Cash & Short-Term Investments
133.22M80.91M59.77M293.06M446.83M484.4M577.58M582.91M394.07M352.06M
Cash Only
35.17M33.77M24.61M115.24M221.97M74.36M295.39M154.08M134.93M130.89M
Short-Term Investments
94.81M47.14M35.17M177.82M224.87M410.04M282.19M428.83M259.14M221.17M
Accounts Receivable
377K253K116K175K429K4.06M1.23M13.87M38M38.12M
Days Sales Outstanding
65.2860.8727.9142.111.12--213.8180.4758.38
Inventory
-1.44M1.05M00000366K32.75M34.95M
Days Inventory Outstanding
-------161.731.72K2.32K
Other Current Assets
1.29M1.79M2.06M456K265K117K63K-2.02M63.26M46.05M
Total Non-Current Assets
3.74M592K1.19M1.75M1.26M7.45M32M121.76M1.63M1.49M
Property, Plant & Equipment
267K373K997K482K1.26M1.06M1.5M2.02M1.52M1.39M
Fixed Asset Turnover
7.90x4.07x1.52x3.15x110.79x--11.71x113.17x141.48x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
3.25M0115K005.47M29.83M119.52M082.88M
Other Non-Current Assets
231K219K82K1.27M0922K680K217K102K102K
Total Assets
137.19M▲ 0%
83.94M▼ 38.8%
63.52M▼ 24.3%
300.61M▲ 373.2%
449.66M▲ 49.6%
497.24M▲ 10.6%
612.88M▲ 23.3%
724.82M▲ 18.3%
529.71M▼ 26.9%
472.67M▲ 0%
Asset Turnover
0.02x0.02x0.02x0.01x0.31x--0.03x0.33x0.40x
Asset Growth %
25.84%-38.81%-24.32%373.22%49.58%10.58%23.26%18.26%-26.92%1.43%
Total Current Liabilities
15.8M16.11M18.37M18.87M20.68M29.07M58.1M103.55M120.12M86.17M
Accounts Payable
2.23M1.44M6.18M3.51M5.67M4.35M9.96M11.63M16.58M10.84M
Days Payables Outstanding
-------5.14K868.251.2K
Short-Term Debt
0002.29M00012.12M472K0
Deferred Revenue (Current)
1.57M1.52M1.52M1.52M000000
Other Current Liabilities
9.6M10.35M7.39M3.74M6.23M6.55M35.92M79.33M103.06M75.33M
Current Ratio
8.45x5.18x3.39x15.84x21.68x16.85x10.00x5.82x4.40x5.47x
Quick Ratio
8.54x5.11x3.39x15.84x21.68x16.85x10.00x5.82x4.12x5.06x
Cash Conversion Cycle
--------4.76K927.451.17K
Total Non-Current Liabilities
17.07M14.79M13.56M29.55M20.61M722K588K333.14M344.96M258.7M
Long-Term Debt
00017.83M19.89M00331.56M344.96M0
Capital Lease Obligations
00419K101K711K722K588K1.58M1.05M3.57M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
310K136K5K1K0000-1.05M258.7M
Total Liabilities
32.87M30.89M31.93M48.42M41.29M29.79M58.68M436.69M465.08M344.87M
Total Debt
00897K20.54M20.97M1.16M1.64M345.74M346.48M0
Net Debt
-35.17M-33.77M-23.71M-94.71M-201M-73.19M-293.76M191.66M211.55M-130.89M
Debt / Equity
--0.03x0.08x0.05x0.00x0.00x1.20x5.36x0.00x
Debt / EBITDA
----0.80x-----0.00x
Net Debt / EBITDA
-----7.65x----0.60x
Interest Coverage
-43.60x-38.08x--30.04x14.13x-46.61x-1005.54x-63.67x-7.45x-2.31x
Total Equity
104.32M▲ 0%
53.05M▼ 49.1%
31.6M▼ 40.4%
252.19M▲ 698.1%
408.37M▲ 61.9%
467.45M▲ 14.5%
554.2M▲ 18.6%
288.12M▼ 48.0%
64.63M▼ 77.6%
41.62M▲ 0%
Equity Growth %
23.98%-49.15%-40.43%698.06%61.93%14.47%18.56%-48.01%-77.57%-290.47%
Book Value per Share
4.972.091.046.117.847.697.883.370.750.47
Total Shareholders' Equity
104.32M53.05M31.6M252.19M408.37M467.45M554.2M288.12M64.63M41.62M
Common Stock
2K2K3K5K6K7K8K9K9K9K
Retained Earnings
-366.11M-439.42M-495.47M-568.63M-543.7M-693.04M-902.4M-1.22B-1.51B-1.55B
Treasury Stock
0000000000
Accumulated OCI
-143K-25K0-4K45K-806K218K163K452K0
Minority Interest
0000000000

SNDX Cash Flow Statement

Syndax Pharmaceuticals, Inc. (SNDX) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-47.37M-68.53M-50.61M-71.26M29.13M-133.68M-160.6M-274.9M-322.98M-278.16M
Operating CF Margin %
-2247.2%-4517.53%-3336.32%-4697.43%20.85%---1160.91%-187.4%-
Operating CF Growth %
-34.74%-44.67%26.15%-40.8%140.88%-558.88%-20.14%-71.17%-17.49%-9.71%
Net Income
-60.8M-73.96M-56.05M-73.16M24.93M-149.34M-209.36M-318.76M-285.42M-243.25M
Depreciation & Amortization
76K78K92K89K43K33K12K8K6K-102K
Stock-Based Compensation
5.45M6.2M6M9.06M13.32M16.02M30.95M43.03M47.5M49.18M
Deferred Taxes
223K-558K-780K0255K00000
Other Non-Cash Items
8K11K359K686K187K-2.04M-14.06M-12.45M-5.75M-22.1M
Working Capital Changes
7.67M-302K-241K-7.93M-9.6M1.66M31.86M13.27M-79.32M-61.89M
Change in Receivables
00000-3.47M0-11.24M-36.83M-28.88M
Change in Inventory
000003.47M0-366K-32.09M-29.96M
Change in Payables
-194K-792K4.74M-2.67M2.16M-1.32M5.61M1.67M4.95M796K
Cash from Investing
-17.03M51.4M12.78M-142.53M-40.87M-186.19M117.61M-219.78M290.04M234.28M
Capital Expenditures
-84K-187K00-129K-225K00-187K-187K
CapEx % of Revenue
3.98%12.33%--0.09%---0.11%0.09%
Acquisitions
000040.74K225K0000
Investments
----------
Other Investing
45K51.59K12.78K0-40.74K225K0000
Cash from Financing
75.72M15.73M28.57M304.42M118.46M172.25M264.13M353.37M13.68M20.66M
Debt Issued (Net)
00019.73M0-21M0000
Equity Issued (Net)
75.35M15.5M28.21M278.06M86.34M181.39M258.09M9.71M13.68M12.75M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
374K232K360K6.63M32.13M11.86M6.04M343.65M07.92M
Net Change in Cash
11.32M▲ 0%
-1.4M▼ 112.4%
-9.26M▼ 559.6%
90.63M▲ 1078.7%
106.72M▲ 17.8%
-147.61M▼ 238.3%
221.14M▲ 249.8%
-141.31M▼ 163.9%
-19.27M▲ 86.4%
-23.21M▲ 0%
Free Cash Flow
-47.45M▲ 0%
-68.72M▼ 44.8%
-50.61M▲ 26.3%
-71.26M▼ 40.8%
29M▲ 140.7%
-133.9M▼ 561.7%
-160.6M▼ 19.9%
-274.9M▼ 71.2%
-323.17M▼ 17.6%
-278.35M▲ 0%
FCF Margin %
-2251.19%-4529.86%-3336.32%-4697.43%20.76%---1160.91%-187.5%-128.17%
FCF Growth %
-33.99%-44.81%26.35%-40.8%140.7%-561.69%-19.94%-71.17%-17.56%2.85%
FCF per Share
-2.26-2.71-1.66-1.730.56-2.20-2.28-3.21-3.73-
FCF Conversion (FCF/Net Income)
0.78x0.93x0.90x0.98x1.17x0.90x0.77x0.86x1.13x1.14x
Interest Paid
0000000000
Taxes Paid
0000000000

SNDX Key Ratios

Syndax Pharmaceuticals, Inc. (SNDX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-64.53%-94%-132.21%-51.5%7.55%-34.1%-40.98%-75.69%-161.82%-256.66%
Return on Invested Capital (ROIC)
-71.79%-128.71%-317.71%-64.79%10.78%-37.84%-52.69%-68.83%-54.19%-115.33%
Gross Margin
100%100%100%100%100%--96.51%95.96%97.96%
Net Margin
-2884.35%-4875.48%-3688.53%-4816.68%17.84%---1346.11%-165.6%-112.01%
Debt / Equity
--0.03x0.08x0.05x0.00x0.00x1.20x5.36x0.00x
Interest Coverage
-43.60x-38.08x--30.04x14.13x-46.61x-1005.54x-63.67x-7.45x-2.31x
FCF Conversion
0.78x0.93x0.90x0.98x1.17x0.90x0.77x0.86x1.13x1.14x
Revenue Growth
72.79%-28.04%0%0%9109.56%-100%--627.84%396.72%
Related:SNDX Dividend History·SNDX Revenue History·SNDX Price History·SNDX P/E History·SNDX Financial Ratios·SNDX Institutional Holders

SNDX SEC Filings & Documents

Syndax Pharmaceuticals, Inc. (SNDX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 30, 2026·SEC

Material company update

Feb 26, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Mar 3, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Apr 30, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 4, 2025·SEC

SNDX Frequently Asked Questions

Syndax Pharmaceuticals, Inc. (SNDX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Syndax Pharmaceuticals, Inc. (SNDX) reported $217.2M in revenue for fiscal year 2025.

Syndax Pharmaceuticals, Inc. (SNDX) grew revenue by 627.8% over the past year. This is strong growth.

Syndax Pharmaceuticals, Inc. (SNDX) reported a net loss of $243.2M for fiscal year 2025.

Dividend & Returns

Syndax Pharmaceuticals, Inc. (SNDX) has a return on equity (ROE) of -161.8%. Negative ROE indicates the company is unprofitable.

Syndax Pharmaceuticals, Inc. (SNDX) had negative free cash flow of $278.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SNDX back in 2011?

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