Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in STTK held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 6.3M | $40.5M | 0.0% | 13.164% | 0.85% |
| 2 | Redmile Group, LLC | 5.5M | $35.6M | 0.0% | 11.564% | 2.36% |
| 3 | Prosight Management, LP | 5.0M | $32.2M | +110.1% | 10.447% | 5.28% |
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.6M | $29.9M | -26.3% | 9.697% | 0.05% |
| 5 | NEXTBio Capital Management LP | 3.1M | $20.3M | 0.0% | 6.576% | 9.40% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 2.3M | $14.6M | — | 4.754% | 0.00% |
| 7 | CLARK ESTATES INC/NY | 1.5M | $9.5M | 0.0% | 3.080% | 2.28% |
| 8 | PINNACLE ASSOCIATES LTD | 1.4M | $8.8M | +1.3% | 2.856% | 0.11% |
| 9 | abrdn plc | 1.2M | $7.5M | +118.3% | 2.420% | 0.01% |
| 10 | Point72 Asset Management, L.P. | 1.0M | $6.6M | -3.5% | 2.152% | 0.01% |
| 11 | AMERIPRISE FINANCIAL INC | 906K | $5.8M | +7775.7% | 1.891% | 0.00% |
| 12 | 683 Capital Management, LLC | 800K | $5.1M | -42.4% | 1.670% | 0.40% |
| 13 | MILLENNIUM MANAGEMENT LLC | 764K | $4.9M | +60.0% | 1.594% | 0.00% |
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 716K | $4.6M | +382.4% | 1.495% | 0.00% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 646K | $4.2M | +4.4% | 1.348% | 0.00% |
| 16 | RENAISSANCE TECHNOLOGIES LLC | 605K | $3.9M | +77.4% | 1.262% | 0.01% |
| 17 | MARSHALL WACE, LLP | 581K | $3.7M | +18.7% | 1.214% | 0.00% |
| 18 | BlackRock, Inc. | 511K | $3.3M | +22.1% | 1.066% | 0.00% |
| 19 | S&G Foundation | 436K | $2.8M | — | 0.910% | 0.15% |
| 20 | JANE STREET GROUP, LLC | 416K | $2.7M | +669.6% | 0.868% | 0.02% |
| 21 | FMR LLC | 393K | $2.5M | -0.0% | 0.819% | 0.00% |
| 22 | TD ASSET MANAGEMENT INC | 383K | $2.5M | +52.4% | 0.799% | 0.00% |
| 23 | VANGUARD FIDUCIARY TRUST CO | 325K | $2.1M | — | 0.678% | 0.00% |
| 24 | TWO SIGMA INVESTMENTS, LP | 316K | $2.0M | -27.8% | 0.660% | 0.00% |
| 25 | DIADEMA PARTNERS LP | 294K | $1.9M | — | 0.613% | 0.60% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in STTK — a direct measure of their conviction.
Filings activity in STTK during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new STTK position in Q1 2026
Institutions that fully closed their STTK position in Q1 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 83 | +28% | 118.97% | +59.48 pp | $282M | +100% |
| Q4 2025 | 65 | +18% | 59.49% | +23.22 pp | $141M | +64% |
| Q3 2025 | 55 | 11% | 36.27% | +26.79 pp | $86M | +282% |
| Q2 2025 | 62 | 18% | 9.48% | 2.87 pp | $22M | 23% |
| Q1 2025 | 76 | +0.0% | 12.35% | 4.58 pp | $29M | 27% |
| Q4 2024 | 76 | +0.0% | 16.93% | 34.39 pp | $40M | 67% |
| Q3 2024 | 76 | +5.6% | 51.32% | 2.88 pp | $121M | 5.3% |
| Q2 2024 | 72 | — | 54.20% | — | $128M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying STTK stock.
Based on Q1 2026 13F filings, institutional ownership of Shattuck Labs, Inc. stands at 119.0%, held across 83 reporting institutions.
ORBIMED ADVISORS LLC is the largest reported institutional holder of STTK, with approximately 6,306,127 shares worth $0.04B as of Q1 2026.
Yes — 6 widely-followed marquee investors appear among the top 25 institutional holders of STTK, including Point72 Asset Management, L.P., MILLENNIUM MANAGEMENT LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP, RENAISSANCE TECHNOLOGIES LLC, JANE STREET GROUP, LLC.
Our composite Smart Money Score for STTK is 86 out of 100 (Strong Smart Money). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
24 institutions opened new positions in STTK during Q1 2026, while 6 fully exited. 53 added to existing positions and 4 trimmed.
STTK institutional ownership rose by 59.48 percentage points quarter-over-quarter, with a net change of +18 holders.
The top 10 institutions account for 73.0% of all reported 13F value in STTK, and the top 25 account for 91.5%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Shattuck Labs, Inc. (STTK) Institutional Ownership