Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in TNGX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 13.9M | $434.5M | +4.5% | 8.538% | 3.71% |
| 2 | BlackRock, Inc. | 12.4M | $388.8M | +42.2% | 7.640% | 0.01% |
| 3 | FMR LLC | 12.3M | $385.5M | +24.5% | 7.575% | 0.02% |
| 4 | FARALLON CAPITAL MANAGEMENT, L.L.C. | 12.3M | $383.8M | +34.9% | 7.540% | 1.77% |
| 5 | Boxer Capital Management, LLC | 10.9M | $340.0M | 0.0% | 6.680% | 25.61% |
| 6 | GOLDMAN SACHS GROUP INC | 10.0M | $312.0M | +96.6% | 6.130% | 0.03% |
| 7 | TCG Crossover Management, LLC | 9.1M | $283.9M | -13.8% | 5.578% | 6.82% |
| 8 | Paradigm Biocapital Advisors LP | 6.4M | $198.7M | +58.6% | 3.905% | 3.72% |
| 9 | Siren, L.L.C. | 6.2M | $193.2M | +9.2% | 3.795% | 3.91% |
| 10 | STATE STREET CORP | 6.0M | $186.9M | +28.5% | 3.673% | 0.00% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 6.0M | $186.2M | +15.4% | 3.659% | 0.00% |
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.6M | $175.1M | -56.3% | 3.440% | 0.25% |
| 13 | Jupiter Topco LLC | 5.1M | $158.0M | — | 3.106% | 0.06% |
| 14 | Deep Track Capital, LP | 4.2M | $131.3M | +52.7% | 2.580% | 1.91% |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4.2M | $131.0M | +1.1% | 2.574% | 1.37% |
| 16 | Woodline Partners LP | 4.0M | $125.1M | -50.0% | 2.457% | 0.39% |
| 17 | TRV GP IV, LLC | 6.4M | $120.2M | 0.0% | 3.915% | 47.37% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 3.7M | $117.0M | +39.9% | 2.299% | 0.01% |
| 19 | PERCEPTIVE ADVISORS LLC | 3.4M | $105.6M | +317.9% | 2.074% | 1.58% |
| 20 | Seven Fleet Capital Management LP | 3.2M | $95.7M | +543.0% | 1.983% | 15.79% |
| 21 | Logos Global Management LP | 2.9M | $89.1M | -5.0% | 1.750% | 3.84% |
| 22 | Caligan Partners LP | 2.5M | $78.2M | +3.8% | 1.536% | 3.68% |
| 23 | Holocene Advisors, LP | 2.4M | $75.4M | -38.7% | 1.481% | 0.17% |
| 24 | Commodore Capital LP | 2.3M | $70.3M | — | 1.382% | 4.19% |
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 2.1M | $66.2M | -44.7% | 1.300% | 0.08% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in TNGX — a direct measure of their conviction.
Filings activity in TNGX during Q2 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 245 | +26% | 131.68% | +2.24 pp | $6.37B | +71% |
| Q1 2026 | 195 | +15% | 129.44% | 1.74 pp | $3.73B | +146% |
| Q4 2025 | 170 | +22% | 131.18% | +1.27 pp | $1.52B | +33% |
| Q3 2025 | 139 | +19% | 129.91% | +11.14 pp | $1.14B | +81% |
| Q2 2025 | 117 | 3.3% | 118.77% | +16.29 pp | $630M | +352% |
| Q1 2025 | 121 | 12% | 102.48% | +1.86 pp | $139M | 55% |
| Q4 2024 | 138 | +13% | 100.62% | +5.52 pp | $308M | 57% |
| Q3 2024 | 122 | — | 95.10% | — | $714M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying TNGX stock.
Based on Q2 2026 13F filings, institutional ownership of Tango Therapeutics, Inc. stands at 131.7%, held across 245 reporting institutions.
RTW INVESTMENTS, LP is the largest reported institutional holder of TNGX, with approximately 13,900,620 shares worth $0.43B as of Q2 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of TNGX.
Our composite Smart Money Score for TNGX is 59 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
70 institutions opened new positions in TNGX during Q2 2026, while 22 fully exited. 139 added to existing positions and 30 trimmed.
TNGX institutional ownership rose by 2.24 percentage points quarter-over-quarter, with a net change of +50 holders.
The top 10 institutions account for 48.8% of all reported 13F value in TNGX, and the top 25 account for 75.8%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Tango Therapeutics, Inc. (TNGX) Institutional Ownership