Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in TNGX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 13.3M | $278.2M | +791.9% | 11.449% | 2.77% |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 12.8M | $268.0M | +20.8% | 11.026% | 0.41% |
| 3 | Boxer Capital Management, LLC | 10.9M | $227.5M | 0.0% | 9.362% | 29.87% |
| 4 | TCG Crossover Management, LLC | 10.5M | $220.3M | -17.5% | 9.065% | 6.30% |
| 5 | FMR LLC | 9.9M | $207.2M | +245.4% | 8.527% | 0.01% |
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 9.1M | $190.3M | -30.3% | 7.831% | 1.24% |
| 7 | BlackRock, Inc. | 8.7M | $183.0M | +2.4% | 7.530% | 0.00% |
| 8 | Woodline Partners LP | 8.0M | $167.4M | -20.6% | 6.886% | 0.63% |
| 9 | Nextech Invest, Ltd. | 7.3M | $152.0M | 0.0% | 6.255% | 10.70% |
| 10 | TRV GP IV, LLC | 6.4M | $133.4M | -19.1% | 5.487% | 49.96% |
| 11 | Siren, L.L.C. | 5.7M | $118.3M | -30.7% | 4.870% | 3.28% |
| 12 | VANGUARD CAPITAL MANAGEMENT LLC | 5.2M | $108.0M | — | 4.443% | 0.00% |
| 13 | GOLDMAN SACHS GROUP INC | 5.1M | $106.2M | +2.7% | 4.370% | 0.01% |
| 14 | STATE STREET CORP | 4.7M | $97.3M | -25.2% | 4.004% | 0.00% |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 4.1M | $86.8M | +42.6% | 3.570% | 1.02% |
| 16 | Paradigm Biocapital Advisors LP | 4.0M | $83.9M | — | 3.451% | 1.71% |
| 17 | Holocene Advisors, LP | 3.9M | $82.3M | — | 3.385% | 0.20% |
| 18 | BALYASNY ASSET MANAGEMENT LLC | 3.8M | $80.1M | -27.5% | 3.294% | 0.27% |
| 19 | Logos Global Management LP | 3.0M | $62.8M | -28.6% | 2.582% | 3.13% |
| 20 | Deep Track Capital, LP | 2.8M | $57.5M | +12.0% | 2.367% | 1.19% |
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 2.7M | $56.0M | +4.8% | 2.303% | 0.00% |
| 22 | Caligan Partners LP | 2.4M | $50.4M | -35.4% | 2.074% | 3.50% |
| 23 | Bellevue Group AG | 2.4M | $50.2M | -38.9% | 2.066% | 1.19% |
| 24 | JANUS HENDERSON GROUP PLC | 2.4M | $50.1M | -9.4% | 2.062% | 0.02% |
| 25 | Vivo Capital, LLC | 2.2M | $45.1M | 0.0% | 1.855% | 3.76% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in TNGX — a direct measure of their conviction.
Filings activity in TNGX during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 191 | +13% | 103.53% | +61.38 pp | $3.72B | +146% |
| Q4 2025 | 169 | +22% | 42.15% | +10.42 pp | $1.51B | +33% |
| Q3 2025 | 139 | +19% | 31.73% | +14.21 pp | $1.14B | +81% |
| Q2 2025 | 117 | 3.3% | 17.52% | +13.64 pp | $630M | +352% |
| Q1 2025 | 121 | 12% | 3.88% | 4.68 pp | $139M | 55% |
| Q4 2024 | 138 | +13% | 8.56% | 11.30 pp | $308M | 57% |
| Q3 2024 | 122 | +3.4% | 19.86% | 2.03 pp | $714M | 9.3% |
| Q2 2024 | 118 | — | 21.89% | — | $787M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying TNGX stock.
Based on Q1 2026 13F filings, institutional ownership of Tango Therapeutics, Inc. stands at 103.5%, held across 191 reporting institutions.
RTW INVESTMENTS, LP is the largest reported institutional holder of TNGX, with approximately 13,300,620 shares worth $0.28B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of TNGX.
Our composite Smart Money Score for TNGX is 50 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
59 institutions opened new positions in TNGX during Q1 2026, while 37 fully exited. 120 added to existing positions and 11 trimmed.
TNGX institutional ownership rose by 61.38 percentage points quarter-over-quarter, with a net change of +22 holders.
The top 10 institutions account for 54.5% of all reported 13F value in TNGX, and the top 25 account for 85.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Tango Therapeutics, Inc. (TNGX) Institutional Ownership