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VRTXVertex Pharmaceuticals Incorporated
$491.34$125.0B
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HomeStocksVRTXCash Flow

Vertex Pharmaceuticals Incorporated (VRTX) Cash Flow Statement

30Y historyFree accessUpdated daily

Cash conversion efficiency remains variable, evidenced by an OCF/NI ratio that fluctuated from 0.24 in 2023Q4 to 1.38 in 2026Q1 due to significant R&D-related accounting charges.

VRTX Cash Flow Statement

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly
MetricTTMDec'25Dec'24Dec'23Dec'22Dec'21Dec'20Dec'19Dec'18Dec'17Dec'16Dec'15Dec'14Dec'13Dec'12Dec'11Dec'10Dec'09Dec'08Dec'07Dec'06Dec'05Dec'04Dec'03Dec'02Dec'01Dec'00Dec'99Dec'98Dec'97Dec'96
Cash from Operations4.24B3.63B-492.6M3.54B4.13B2.64B3.25B1.57B1.27B844.94M236.1M-365.43M-513.2M-51.57M267.84M143.74M-635.44M-427.59M-226.48M-252.48M-22.48M-172.05M-142.16M-167.62M-79.54M-8.07M-16.64M-31.8M-31.1M-9.4M-40.3M
Operating CF Margin %-30.07%-4.47%35.84%46.24%34.9%52.43%37.7%41.68%33.95%13.87%-35.4%-88.42%-4.25%17.54%10.19%-443.22%-419%-129.05%-126.86%-10.39%-106.94%-138.4%-242.44%-49.38%-4.82%-21.3%-51.62%-70.05%-21.46%-303.01%
Operating CF Growth %178.79%837.19%-113.93%-14.35%56.23%-18.75%107.32%23.54%50.34%257.87%164.61%28.79%-895.15%-119.25%86.34%122.62%-48.61%-88.79%10.3%-1023.36%86.94%-21.03%15.19%-110.74%-885.13%51.49%47.66%-2.25%-230.85%76.67%-151.88%
Net Income4.34B3.95B-535.6M3.62B3.32B2.34B2.71B1.18B2.09B91.64M-84.03M-588.18M-742.75M-687.55M-51.13M41.18M-754.63M-642.18M-459.85M-391.28M-206.89M-203.42M-166.25M-196.77M-108.62M-66.23M-39.66M-41M-33.1M-19.8M-40M
Depreciation & Amortization217.3M207.2M207.2M181.3M148.3M125.6M109.52M106.94M72.42M61.4M61.4M62.34M63.26M48.37M38.19M35.04M30.46M30.11M32.2M27.46M25.87M27.29M29.64M23.44M25.43M17.96M9.1M6.3M4.5M3.6M3.2M
Stock-Based Compensation686.2M0698.5M581.2M491.3M441.4M429.5M360.49M325.05M290.74M237.71M231.03M177.54M127.3M114.28M126.75M97.68M86.72M63.01M59.41M39.14M7.53M4.17M3.15M1.5M000000
Deferred Taxes-384.5M-510.8M-348.8M-536.5M-275.9M-154.6M277.34M167.39M-1.51B-120.51M16.96M3.28M281K-285.05M36.66M-7.5M54.86M-2.23M0-59.11M-50.23M-7.53M-4.17M-3.15M-1.5M000000
Other Non-Cash Items69.2M1.18B900K-42.6M103.4M-5.8M-220.04M-176.2M60.02M506.42M6.14M12.05M-471K750.42M143.63M141.33M-31K38.56M-622K63.75M46.58M56.15M7.19M-63.24M2.78M-895K4.13M1.4M-600K-100K-200K
Working Capital Changes-685.9M-1.2B-514.8M-265.7M340.8M-105.2M-54.45M-66.1M238.02M15.26M-2.07M-85.95M-11.06M-5.05M-13.79M-193.06M-63.78M61.42M138.78M47.3M123.05M-52.07M-12.74M68.94M867K41.09M9.79M1.5M-1.9M6.9M-3.3M
Change in Receivables-137.9M-347.3M-99.3M-84.1M-358.6M-274.7M-223.44M-225.59M-108.15M-71.76M-33.03M-104.85M7.43M53.36M39.91M-170.61M-2.92M13.9M7.83M31.6M-42.33M-8.7M-4.57M1.57M13.64M000000
Change in Inventory-454.8M-524.2M-517.3M-322.9M-136.4M-92.8M-132.01M-64.05M-31.96M-44.98M-16.45M-23.15M-16.47M7.14M-29.93M-111.39M6.19M9.52M-3.15M19.54M48.25M0070.75M0000000
Change in Payables46.2M36.8M49.5M48.7M120.8M31.9M51.28M-22.79M36.55M8.75M-11.74M-1.71M25.05M-49.23M14.89M37.47M-1.18M-15.06M19.01M17.38M9.16M-450K-5.65M-2.15M3.19M000000
Cash from Investing-1.32B-945.4M-3.77B-3.14B-321.1M-340.9M99.39M-1.24B-202.16M-437.68M104.47M268.86M73.96M-54.13M-425.82M212.41M7.3M-508.73M-360.65M405.17M-208.47M-1.73M107.43M119.58M-15.96M-145.09M-236.33M36.4M-20.4M-118.8M-40.4M
Capital Expenditures-530.3M-437.6M-297.7M-200.4M-204.7M-235M-259.8M-75.45M-95.52M-259.42M-56.56M-45.3M-51.2M-51.39M-71.14M-94.59M-38.05M-23.5M-32.18M-32.41M-32.42M-16.96M-12.49M-17.35M-41.22M-53.9M-11.91M-16.2M-7.9M-6M-4M
CapEx % of Revenue4.33%3.62%2.7%2.03%2.29%3.1%4.19%1.81%3.13%10.42%3.32%4.39%8.82%4.24%4.66%6.71%26.54%23.02%18.34%16.29%14.98%10.54%12.16%25.1%25.59%32.18%15.25%26.3%17.79%13.7%30.08%
Acquisitions0000-295.9M77M-418.24M-1.15B0-160M0-80M-10M00-60M0-87.42M032.98M00097.15M6K000000
Investments-------------------------------
Other Investing-19.4M-24.7M-241.7M-89M-47.8M-77M418.24M0-22.82M145.11M33.17M-40.24M1.39M61.39M-16.77M72.51M-4.73M624K-696K-32.98M29.59M8.31M-23.92M1.63M200K-14.59M-233K-10.3M-300K-200K400K
Cash from Financing-2.12B-2.26B-1.49B-562.2M-67.7M-1.48B-505.28M126.77M-71.22M68.4M133.27M188.92M497.38M180.88M172.2M-124.24M425.06M999.01M620.74M-10.19M365.87M197.46M-8.63M37.47M13.84M-3.98M544.03M2.8M4.2M164.8M87.1M
Debt Issued (Net)-4.1M-5.4M-33.6M-44.9M-85.5M-18.7M-29.02M-29.14M-12.55M-284.67M-6.86M3.33M272.46M-83.74M-21.49M-155M391.64M149.77M258.61M-42.1M00-12.56M25.51M1.01M-23.64M499.54M-2.7M1.4M-1.3M1.5M
Equity Issued (Net)-1.79B-1.89B-1.06B-293M186.3M-1.32B-274.19M151.23M-60.75M344.84M68.23M185.59M274.62M265.88M191.72M124.86M33.43M849.24M362.13M31.96M366.04M197.59M8.74M11.96M13.33M18.63M119.79M5.5M2.8M164.9M85.5M
Dividends Paid0000000000000000000000000000000
Share Repurchases-1.93B-2.02B-1.18B-427.6M0-1.43B-539.14M-192.01M-350.04M0000000000000000000000
Other Financing-322.9M-366.2M-398.8M-224.3M-168.5M-130.2M-202.07M4.68M2.08M8.23M75M02.16M-1.25M1.97M-94.1M-22K-131K0-53K-170K-119K-4.8M0-499K0-75.29M001.2M100K
Net Change in Cash819.5M515.6M-5.8B-139.7M3.71B811.2M2.87B462.43M990.73M481.47M469.18M89.51M55.96M79.89M14.09M232.12M-203.46M57.54M33.45M142.49M135.13M23.04M-43.15M-9.94M-81.11M-157.45M290.54M7.3M4.2M164.8M87.1M
Free Cash Flow3.71B3.19B-790.3M3.28B3.93B2.41B2.99B1.49B1.17B585.52M179.54M-410.73M-564.4M-102.96M196.7M49.14M-673.5M-451.08M-258.66M-284.89M-54.89M-189.01M-154.66M-184.97M-120.76M-61.97M-28.56M-48M-39M-15.4M-44.3M
FCF Margin %30.28%26.45%-7.17%33.22%43.95%31.8%48.24%35.89%38.55%23.53%10.55%-39.79%-97.24%-8.5%12.88%3.48%-469.76%-442.02%-147.38%-143.15%-25.37%-117.48%-150.56%-267.53%-74.97%-37%-36.55%-77.92%-87.84%-35.16%-333.08%
FCF Growth %394.94%504.13%-124.1%-16.47%62.97%-19.55%100.4%27.16%100.64%226.12%143.71%27.23%-448.16%-152.34%300.29%107.3%-49.31%-74.39%9.21%-419%70.96%-22.22%16.39%-53.18%-94.86%-117.02%40.51%-23.08%-153.25%65.24%-107.01%
FCF per Share14.4812.38-3.0612.5915.159.2711.375.734.532.310.73-1.70-2.40-0.460.930.24-3.36-2.60-1.84-2.21-0.48-2.12-1.97-2.40-1.59-0.83-0.42-0.94-0.77-0.32-1.19
FCF Conversion (FCF/Net Income)0.86x0.92x0.92x0.98x1.24x1.13x1.20x1.33x0.61x3.21x-2.11x0.65x0.69x0.12x-2.50x4.86x0.84x0.67x0.49x0.65x0.11x0.85x0.86x0.85x0.73x0.12x0.42x0.78x0.94x0.47x1.01x
Interest Paid12.9M030.5M43.1M52.3M56.3M54.5M55.6M66.46M68.7M085.61M68.96M13.46M13.4M0000000000000000
Taxes Paid1.46B01.08B1.68B1.06B476.3M191.8M24.7M12.4M6.41M01.81M1.21M2.84M9.32M0000000000000000

Key Metrics

Growth RegimeStable
ProfitabilityStrong
Balance SheetFortress
Cash FlowRobust
Top Statement Risk

IRA pricing negotiation exposure

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Earnings Quality and Cash Conversion

As reported in recent financial filings, Vertex demonstrates a variable cash conversion profile, with the OCF/NI ratio fluctuating significantly from 0.24 in 2023Q4 to 1.38 in 2026Q1, reflecting the impact of lumpy R&D-related accounting charges on the company's reported net income figures.

The divergence between net income and operating cash flow suggests that headline earnings are frequently obscured by non-cash or non-recurring charges, particularly those related to pipeline development. Investors should monitor these fluctuations as they indicate that reported profitability may not always align with the immediate cash-generating capacity of the core cystic fibrosis franchise.

Free Cash Flow Margin Volatility

Based on quarterly cash flow statements, Vertex's free cash flow margins have exhibited notable volatility, ranging from a negative 144.8% during the 2024Q2 R&D-heavy period to a robust 47.0% in 2024Q3, highlighting the sensitivity of cash generation to the company's aggressive investment cycle.

While the core business remains a cash-generating engine, the FCF trajectory is heavily influenced by the timing of strategic investments and R&D expenditures. This suggests that while the underlying business model is highly profitable, the company's commitment to long-term pipeline expansion creates periodic pressure on free cash flow availability.

Working Capital Dynamics and Seasonality

According to historical cash flow data, Vertex experiences significant working capital swings, with quarterly changes ranging from a $947.8 million outflow in 2025Q4 to a $244.7 million inflow in 2026Q1, suggesting that timing of payments and collections creates meaningful noise in quarterly cash flow reporting.

These large swings in working capital appear to be driven by the timing of international reimbursement deals and inventory management for the company's specialized therapeutic portfolio. Analysts should interpret these movements as operational timing differences rather than fundamental shifts in the efficiency of the company's core revenue collection processes.

Aggressive Capital Allocation Strategy

As evidenced by the absence of dividends and consistent share repurchases totaling over $300 million in several recent quarters, Vertex prioritizes capital reinvestment and shareholder returns over cash accumulation, reflecting management's confidence in the internal rate of return for its ongoing research and development initiatives.

The company's decision to deploy significant cash toward buybacks while maintaining a fortress balance sheet suggests a disciplined approach to capital allocation. This strategy appears to signal that management views the current pipeline as the most effective vehicle for long-term value creation compared to alternative uses of capital.

VRTX — Frequently Asked Questions

Quick answers to the most common questions about buying VRTX stock.

How much cash does Vertex Pharmaceuticals Incorporated (VRTX) generate from operations?

Vertex Pharmaceuticals Incorporated (VRTX) generated $3.63B in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.

What is Vertex Pharmaceuticals Incorporated's free cash flow?

Vertex Pharmaceuticals Incorporated (VRTX) generated $3.19B in free cash flow in 2025. Free cash flow is the cash left over after capital expenditures, which can be used to pay dividends, repurchase shares, or pay down debt.

What is Vertex Pharmaceuticals Incorporated's capital expenditure (CapEx)?

Vertex Pharmaceuticals Incorporated (VRTX) spent $437.6M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.

How does Vertex Pharmaceuticals Incorporated distribute cash to shareholders?

In 2025, Vertex Pharmaceuticals Incorporated (VRTX) spent $2.02B on share repurchases. This shows the company's commitment to returning capital to its equity investors.