Cash conversion efficiency remains variable, evidenced by an OCF/NI ratio that fluctuated from 0.24 in 2023Q4 to 1.38 in 2026Q1 due to significant R&D-related accounting charges.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 | Dec'98 | Dec'97 | Dec'96 |
|---|
| Cash from Operations | 4.24B | 3.63B | -492.6M | 3.54B | 4.13B | 2.64B | 3.25B | 1.57B | 1.27B | 844.94M | 236.1M | -365.43M | -513.2M | -51.57M | 267.84M | 143.74M | -635.44M | -427.59M | -226.48M | -252.48M | -22.48M | -172.05M | -142.16M | -167.62M | -79.54M | -8.07M | -16.64M | -31.8M | -31.1M | -9.4M | -40.3M |
| Operating CF Margin % | - | 30.07% | -4.47% | 35.84% | 46.24% | 34.9% | 52.43% | 37.7% | 41.68% | 33.95% | 13.87% | -35.4% | -88.42% | -4.25% | 17.54% | 10.19% | -443.22% | -419% | -129.05% | -126.86% | -10.39% | -106.94% | -138.4% | -242.44% | -49.38% | -4.82% | -21.3% | -51.62% | -70.05% | -21.46% | -303.01% |
| Operating CF Growth % | 178.79% | 837.19% | -113.93% | -14.35% | 56.23% | -18.75% | 107.32% | 23.54% | 50.34% | 257.87% | 164.61% | 28.79% | -895.15% | -119.25% | 86.34% | 122.62% | -48.61% | -88.79% | 10.3% | -1023.36% | 86.94% | -21.03% | 15.19% | -110.74% | -885.13% | 51.49% | 47.66% | -2.25% | -230.85% | 76.67% | -151.88% |
| Net Income | 4.34B | 3.95B | -535.6M | 3.62B | 3.32B | 2.34B | 2.71B | 1.18B | 2.09B | 91.64M | -84.03M | -588.18M | -742.75M | -687.55M | -51.13M | 41.18M | -754.63M | -642.18M | -459.85M | -391.28M | -206.89M | -203.42M | -166.25M | -196.77M | -108.62M | -66.23M | -39.66M | -41M | -33.1M | -19.8M | -40M |
| Depreciation & Amortization | 217.3M | 207.2M | 207.2M | 181.3M | 148.3M | 125.6M | 109.52M | 106.94M | 72.42M | 61.4M | 61.4M | 62.34M | 63.26M | 48.37M | 38.19M | 35.04M | 30.46M | 30.11M | 32.2M | 27.46M | 25.87M | 27.29M | 29.64M | 23.44M | 25.43M | 17.96M | 9.1M | 6.3M | 4.5M | 3.6M | 3.2M |
| Stock-Based Compensation | 686.2M | 0 | 698.5M | 581.2M | 491.3M | 441.4M | 429.5M | 360.49M | 325.05M | 290.74M | 237.71M | 231.03M | 177.54M | 127.3M | 114.28M | 126.75M | 97.68M | 86.72M | 63.01M | 59.41M | 39.14M | 7.53M | 4.17M | 3.15M | 1.5M | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Taxes | -384.5M | -510.8M | -348.8M | -536.5M | -275.9M | -154.6M | 277.34M | 167.39M | -1.51B | -120.51M | 16.96M | 3.28M | 281K | -285.05M | 36.66M | -7.5M | 54.86M | -2.23M | 0 | -59.11M | -50.23M | -7.53M | -4.17M | -3.15M | -1.5M | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 69.2M | 1.18B | 900K | -42.6M | 103.4M | -5.8M | -220.04M | -176.2M | 60.02M | 506.42M | 6.14M | 12.05M | -471K | 750.42M | 143.63M | 141.33M | -31K | 38.56M | -622K | 63.75M | 46.58M | 56.15M | 7.19M | -63.24M | 2.78M | -895K | 4.13M | 1.4M | -600K | -100K | -200K |
| Working Capital Changes | -685.9M | -1.2B | -514.8M | -265.7M | 340.8M | -105.2M | -54.45M | -66.1M | 238.02M | 15.26M | -2.07M | -85.95M | -11.06M | -5.05M | -13.79M | -193.06M | -63.78M | 61.42M | 138.78M | 47.3M | 123.05M | -52.07M | -12.74M | 68.94M | 867K | 41.09M | 9.79M | 1.5M | -1.9M | 6.9M | -3.3M |
| Change in Receivables | -137.9M | -347.3M | -99.3M | -84.1M | -358.6M | -274.7M | -223.44M | -225.59M | -108.15M | -71.76M | -33.03M | -104.85M | 7.43M | 53.36M | 39.91M | -170.61M | -2.92M | 13.9M | 7.83M | 31.6M | -42.33M | -8.7M | -4.57M | 1.57M | 13.64M | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | -454.8M | -524.2M | -517.3M | -322.9M | -136.4M | -92.8M | -132.01M | -64.05M | -31.96M | -44.98M | -16.45M | -23.15M | -16.47M | 7.14M | -29.93M | -111.39M | 6.19M | 9.52M | -3.15M | 19.54M | 48.25M | 0 | 0 | 70.75M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 46.2M | 36.8M | 49.5M | 48.7M | 120.8M | 31.9M | 51.28M | -22.79M | 36.55M | 8.75M | -11.74M | -1.71M | 25.05M | -49.23M | 14.89M | 37.47M | -1.18M | -15.06M | 19.01M | 17.38M | 9.16M | -450K | -5.65M | -2.15M | 3.19M | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | -1.32B | -945.4M | -3.77B | -3.14B | -321.1M | -340.9M | 99.39M | -1.24B | -202.16M | -437.68M | 104.47M | 268.86M | 73.96M | -54.13M | -425.82M | 212.41M | 7.3M | -508.73M | -360.65M | 405.17M | -208.47M | -1.73M | 107.43M | 119.58M | -15.96M | -145.09M | -236.33M | 36.4M | -20.4M | -118.8M | -40.4M |
| Capital Expenditures | -530.3M | -437.6M | -297.7M | -200.4M | -204.7M | -235M | -259.8M | -75.45M | -95.52M | -259.42M | -56.56M | -45.3M | -51.2M | -51.39M | -71.14M | -94.59M | -38.05M | -23.5M | -32.18M | -32.41M | -32.42M | -16.96M | -12.49M | -17.35M | -41.22M | -53.9M | -11.91M | -16.2M | -7.9M | -6M | -4M |
| CapEx % of Revenue | 4.33% | 3.62% | 2.7% | 2.03% | 2.29% | 3.1% | 4.19% | 1.81% | 3.13% | 10.42% | 3.32% | 4.39% | 8.82% | 4.24% | 4.66% | 6.71% | 26.54% | 23.02% | 18.34% | 16.29% | 14.98% | 10.54% | 12.16% | 25.1% | 25.59% | 32.18% | 15.25% | 26.3% | 17.79% | 13.7% | 30.08% |
| Acquisitions | 0 | 0 | 0 | 0 | -295.9M | 77M | -418.24M | -1.15B | 0 | -160M | 0 | -80M | -10M | 0 | 0 | -60M | 0 | -87.42M | 0 | 32.98M | 0 | 0 | 0 | 97.15M | 6K | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -19.4M | -24.7M | -241.7M | -89M | -47.8M | -77M | 418.24M | 0 | -22.82M | 145.11M | 33.17M | -40.24M | 1.39M | 61.39M | -16.77M | 72.51M | -4.73M | 624K | -696K | -32.98M | 29.59M | 8.31M | -23.92M | 1.63M | 200K | -14.59M | -233K | -10.3M | -300K | -200K | 400K |
| Cash from Financing | -2.12B | -2.26B | -1.49B | -562.2M | -67.7M | -1.48B | -505.28M | 126.77M | -71.22M | 68.4M | 133.27M | 188.92M | 497.38M | 180.88M | 172.2M | -124.24M | 425.06M | 999.01M | 620.74M | -10.19M | 365.87M | 197.46M | -8.63M | 37.47M | 13.84M | -3.98M | 544.03M | 2.8M | 4.2M | 164.8M | 87.1M |
| Debt Issued (Net) | -4.1M | -5.4M | -33.6M | -44.9M | -85.5M | -18.7M | -29.02M | -29.14M | -12.55M | -284.67M | -6.86M | 3.33M | 272.46M | -83.74M | -21.49M | -155M | 391.64M | 149.77M | 258.61M | -42.1M | 0 | 0 | -12.56M | 25.51M | 1.01M | -23.64M | 499.54M | -2.7M | 1.4M | -1.3M | 1.5M |
| Equity Issued (Net) | -1.79B | -1.89B | -1.06B | -293M | 186.3M | -1.32B | -274.19M | 151.23M | -60.75M | 344.84M | 68.23M | 185.59M | 274.62M | 265.88M | 191.72M | 124.86M | 33.43M | 849.24M | 362.13M | 31.96M | 366.04M | 197.59M | 8.74M | 11.96M | 13.33M | 18.63M | 119.79M | 5.5M | 2.8M | 164.9M | 85.5M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | -1.93B | -2.02B | -1.18B | -427.6M | 0 | -1.43B | -539.14M | -192.01M | -350.04M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | -322.9M | -366.2M | -398.8M | -224.3M | -168.5M | -130.2M | -202.07M | 4.68M | 2.08M | 8.23M | 75M | 0 | 2.16M | -1.25M | 1.97M | -94.1M | -22K | -131K | 0 | -53K | -170K | -119K | -4.8M | 0 | -499K | 0 | -75.29M | 0 | 0 | 1.2M | 100K |
| Net Change in Cash | 819.5M | 515.6M | -5.8B | -139.7M | 3.71B | 811.2M | 2.87B | 462.43M | 990.73M | 481.47M | 469.18M | 89.51M | 55.96M | 79.89M | 14.09M | 232.12M | -203.46M | 57.54M | 33.45M | 142.49M | 135.13M | 23.04M | -43.15M | -9.94M | -81.11M | -157.45M | 290.54M | 7.3M | 4.2M | 164.8M | 87.1M |
| Free Cash Flow | 3.71B | 3.19B | -790.3M | 3.28B | 3.93B | 2.41B | 2.99B | 1.49B | 1.17B | 585.52M | 179.54M | -410.73M | -564.4M | -102.96M | 196.7M | 49.14M | -673.5M | -451.08M | -258.66M | -284.89M | -54.89M | -189.01M | -154.66M | -184.97M | -120.76M | -61.97M | -28.56M | -48M | -39M | -15.4M | -44.3M |
| FCF Margin % | 30.28% | 26.45% | -7.17% | 33.22% | 43.95% | 31.8% | 48.24% | 35.89% | 38.55% | 23.53% | 10.55% | -39.79% | -97.24% | -8.5% | 12.88% | 3.48% | -469.76% | -442.02% | -147.38% | -143.15% | -25.37% | -117.48% | -150.56% | -267.53% | -74.97% | -37% | -36.55% | -77.92% | -87.84% | -35.16% | -333.08% |
| FCF Growth % | 394.94% | 504.13% | -124.1% | -16.47% | 62.97% | -19.55% | 100.4% | 27.16% | 100.64% | 226.12% | 143.71% | 27.23% | -448.16% | -152.34% | 300.29% | 107.3% | -49.31% | -74.39% | 9.21% | -419% | 70.96% | -22.22% | 16.39% | -53.18% | -94.86% | -117.02% | 40.51% | -23.08% | -153.25% | 65.24% | -107.01% |
| FCF per Share | 14.48 | 12.38 | -3.06 | 12.59 | 15.15 | 9.27 | 11.37 | 5.73 | 4.53 | 2.31 | 0.73 | -1.70 | -2.40 | -0.46 | 0.93 | 0.24 | -3.36 | -2.60 | -1.84 | -2.21 | -0.48 | -2.12 | -1.97 | -2.40 | -1.59 | -0.83 | -0.42 | -0.94 | -0.77 | -0.32 | -1.19 |
| FCF Conversion (FCF/Net Income) | 0.86x | 0.92x | 0.92x | 0.98x | 1.24x | 1.13x | 1.20x | 1.33x | 0.61x | 3.21x | -2.11x | 0.65x | 0.69x | 0.12x | -2.50x | 4.86x | 0.84x | 0.67x | 0.49x | 0.65x | 0.11x | 0.85x | 0.86x | 0.85x | 0.73x | 0.12x | 0.42x | 0.78x | 0.94x | 0.47x | 1.01x |
| Interest Paid | 12.9M | 0 | 30.5M | 43.1M | 52.3M | 56.3M | 54.5M | 55.6M | 66.46M | 68.7M | 0 | 85.61M | 68.96M | 13.46M | 13.4M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 1.46B | 0 | 1.08B | 1.68B | 1.06B | 476.3M | 191.8M | 24.7M | 12.4M | 6.41M | 0 | 1.81M | 1.21M | 2.84M | 9.32M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
IRA pricing negotiation exposure
As reported in recent financial filings, Vertex demonstrates a variable cash conversion profile, with the OCF/NI ratio fluctuating significantly from 0.24 in 2023Q4 to 1.38 in 2026Q1, reflecting the impact of lumpy R&D-related accounting charges on the company's reported net income figures.
The divergence between net income and operating cash flow suggests that headline earnings are frequently obscured by non-cash or non-recurring charges, particularly those related to pipeline development. Investors should monitor these fluctuations as they indicate that reported profitability may not always align with the immediate cash-generating capacity of the core cystic fibrosis franchise.
Based on quarterly cash flow statements, Vertex's free cash flow margins have exhibited notable volatility, ranging from a negative 144.8% during the 2024Q2 R&D-heavy period to a robust 47.0% in 2024Q3, highlighting the sensitivity of cash generation to the company's aggressive investment cycle.
While the core business remains a cash-generating engine, the FCF trajectory is heavily influenced by the timing of strategic investments and R&D expenditures. This suggests that while the underlying business model is highly profitable, the company's commitment to long-term pipeline expansion creates periodic pressure on free cash flow availability.
According to historical cash flow data, Vertex experiences significant working capital swings, with quarterly changes ranging from a $947.8 million outflow in 2025Q4 to a $244.7 million inflow in 2026Q1, suggesting that timing of payments and collections creates meaningful noise in quarterly cash flow reporting.
These large swings in working capital appear to be driven by the timing of international reimbursement deals and inventory management for the company's specialized therapeutic portfolio. Analysts should interpret these movements as operational timing differences rather than fundamental shifts in the efficiency of the company's core revenue collection processes.
As evidenced by the absence of dividends and consistent share repurchases totaling over $300 million in several recent quarters, Vertex prioritizes capital reinvestment and shareholder returns over cash accumulation, reflecting management's confidence in the internal rate of return for its ongoing research and development initiatives.
The company's decision to deploy significant cash toward buybacks while maintaining a fortress balance sheet suggests a disciplined approach to capital allocation. This strategy appears to signal that management views the current pipeline as the most effective vehicle for long-term value creation compared to alternative uses of capital.
Quick answers to the most common questions about buying VRTX stock.
Vertex Pharmaceuticals Incorporated (VRTX) generated $3.63B in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Vertex Pharmaceuticals Incorporated (VRTX) generated $3.19B in free cash flow in 2025. Free cash flow is the cash left over after capital expenditures, which can be used to pay dividends, repurchase shares, or pay down debt.
Vertex Pharmaceuticals Incorporated (VRTX) spent $437.6M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
In 2025, Vertex Pharmaceuticals Incorporated (VRTX) spent $2.02B on share repurchases. This shows the company's commitment to returning capital to its equity investors.