Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in VRTX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Capital World Investors | 25.4M | $11.33B | -0.6% | 9.973% | 1.55% |
| 2 | BlackRock, Inc. | 24.0M | $10.70B | +0.9% | 9.424% | 0.19% |
| 3 | Capital Research Global Investors | 21.1M | $9.43B | +22.0% | 8.306% | 1.46% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 16.5M | $7.37B | — | 6.492% | 0.18% |
| 5 | STATE STREET CORP | 11.7M | $5.24B | +0.4% | 4.612% | 0.18% |
| 6 | GEODE CAPITAL MANAGEMENT, LLC | 6.1M | $2.73B | +2.6% | 2.414% | 0.17% |
| 7 | VANGUARD PORTFOLIO MANAGEMENT LLC | 5.1M | $2.30B | — | 2.023% | 0.12% |
| 8 | Capital International Investors | 5.1M | $2.29B | +8.3% | 2.015% | 0.54% |
| 9 | LOOMIS SAYLES & CO L P | 4.0M | $1.79B | -0.7% | 1.574% | 2.41% |
| 10 | ALLIANCEBERNSTEIN L.P. | 3.9M | $1.77B | -13.0% | 1.538% | 0.57% |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 3.2M | $1.43B | -15.9% | 1.263% | 0.27% |
| 12 | MORGAN STANLEY | 3.2M | $1.42B | +2.2% | 1.254% | 0.09% |
| 13 | UBS ASSET MANAGEMENT AMERICAS INC | 3.1M | $1.37B | +1.9% | 1.202% | 0.28% |
| 14 | BANK OF AMERICA CORP /DE/ | 2.9M | $1.29B | -2.0% | 1.131% | 0.09% |
| 15 | JENNISON ASSOCIATES LLC | 2.7M | $1.22B | -15.7% | 1.077% | 0.84% |
| 16 | Clearbridge Investments, LLC | 2.7M | $1.21B | -5.6% | 1.062% | 1.05% |
| 17 | AMERIPRISE FINANCIAL INC | 2.6M | $1.18B | +16.3% | 1.035% | 0.27% |
| 18 | NORTHERN TRUST CORP | 2.6M | $1.15B | -0.6% | 1.008% | 0.15% |
| 19 | Invesco Ltd. | 2.6M | $1.14B | +19.0% | 1.007% | 0.18% |
| 20 | GOLDMAN SACHS GROUP INC | 2.5M | $1.10B | +36.2% | 0.970% | 0.13% |
| 21 | JANUS HENDERSON GROUP PLC | 2.1M | $951.8M | -4.1% | 0.838% | 0.47% |
| 22 | FMR LLC | 2.0M | $902.1M | -8.7% | 0.794% | 0.05% |
| 23 | Legal & General Group Plc | 2.0M | $873.3M | -0.7% | 0.769% | 0.20% |
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.9M | $857.7M | +3.3% | 0.755% | 0.13% |
| 25 | VICTORY CAPITAL MANAGEMENT INC | 1.9M | $843.3M | -43.7% | 0.743% | 0.54% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in VRTX — a direct measure of their conviction.
Filings activity in VRTX during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new VRTX position in Q1 2026
Institutions that fully closed their VRTX position in Q1 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 1,637 | +1.9% | 87.18% | 4.68 pp | $98.67B | 5.1% |
| Q4 2025 | 1,607 | +9.8% | 91.86% | +13.54 pp | $103.96B | +17% |
| Q3 2025 | 1,463 | 3.4% | 78.32% | 13.29 pp | $88.63B | 15% |
| Q2 2025 | 1,515 | 2.5% | 91.61% | 4.68 pp | $103.68B | 4.9% |
| Q1 2025 | 1,554 | +4.5% | 96.29% | +16.56 pp | $108.97B | +21% |
| Q4 2024 | 1,487 | +0.3% | 79.73% | 11.12 pp | $90.23B | 12% |
| Q3 2024 | 1,482 | +0.0% | 90.85% | 3.19 pp | $102.82B | 3.4% |
| Q2 2024 | 1,482 | — | 94.04% | — | $106.43B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying VRTX stock.
Based on Q1 2026 13F filings, institutional ownership of Vertex Pharmaceuticals Incorporated stands at 87.2%, held across 1,637 reporting institutions.
Capital World Investors is the largest reported institutional holder of VRTX, with approximately 25,368,124 shares worth $11.33B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of VRTX.
Our composite Smart Money Score for VRTX is 32 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
178 institutions opened new positions in VRTX during Q1 2026, while 148 fully exited. 530 added to existing positions and 919 trimmed.
VRTX institutional ownership fell by 4.68 percentage points quarter-over-quarter, with a net change of +30 holders.
The top 10 institutions account for 55.7% of all reported 13F value in VRTX, and the top 25 account for 72.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Vertex Pharmaceuticals Incorporated (VRTX) Institutional Ownership