Wall Street analyst price targets, ratings consensus & upside potential · Updated Feb 28, 2026
Last 12 months price action with 12-month analyst target path
As of March 2, 2026, Vertex Pharmaceuticals Incorporated (VRTX) has a Wall Street consensus price target of $545.08, based on estimates from 55 covering analysts. With the stock currently trading at $496.83, this represents a potential upside of +9.7%. The company has a market capitalization of $126.19B.
Analyst price targets range from a low of $441.00 to a high of $607.00, representing a 30% spread in expectations. The median target of $551.50 aligns closely with the consensus average.
The current analyst consensus rating is Buy, with 46 analysts rating the stock as a Buy or Strong Buy,9 rating it Hold, and 0 rating it Sell or Strong Sell. This overwhelmingly bullish sentiment suggests analysts see significant catalysts for upside ahead.
From a valuation perspective, VRTX trades at a trailing P/E of 32.4x and forward P/E of 25.7x. The forward PEG ratio of 3.10 reflects a premium valuation. Analysts expect EPS to grow +35.7% over the next year.
Our proprietary valuation model, which blends historical multiples with forward estimates, suggests a base-case price target of $604.74, with bear and bull scenarios of $26.77 and $1613.01 respectively. Model confidence stands at 59/100, reflecting moderate uncertainty in projections.
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Start ComparisonThe consensus price target for VRTX is $545.08, close to the current price of $496.83 (9.7% implied move). Based on 55 analyst estimates, the stock appears fairly valued near current levels.
VRTX has a consensus rating of "Buy" based on 55 Wall Street analysts. The rating breakdown is predominantly bullish, with 46 Buy/Strong Buy ratings. The consensus 12-month price target of $545.08 implies 9.7% upside from current levels.
VRTX trades at a forward P/E of 25.6628x, representing a moderate valuation. With analysts targeting $545.08 (9.7% implied move), the stock appears reasonably valued with upside.
The most bullish Wall Street analyst has a price target of $607 for VRTX, while the most conservative target is $441. The consensus of $545.08 represents the median expectation. Our quantitative valuation model projects a bull case target of $1613 based on optimistic growth and margin assumptions. These targets typically reflect 12-month expectations.
VRTX is heavily covered by Wall Street, with 55 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 46 have Buy ratings, 9 recommend Hold, and 0 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
The 12-month VRTX stock forecast based on 55 Wall Street analysts shows a consensus price target of $545.08, with estimates ranging from $441 (bear case) to $607 (bull case). The median consensus rating is "Buy". Our proprietary valuation model produces a base case fair value of $605, with bear/bull scenarios of $27/$1613.
Our quantitative valuation model calculates VRTX's fair value at $605 (base case), with a bear case of $27 and bull case of $1613. The model uses discounted cash flow analysis, historical growth rates, and margin mean-reversion to project FY+2 earnings, then applies an appropriate P/E multiple. The model confidence score is 59/100.
VRTX trades at a forward P/E ratio of 25.7x based on next-twelve-months earnings estimates compared to a trailing P/E of 32.4x. The lower forward P/E indicates analysts expect earnings growth. A forward P/E is useful for comparing valuations when earnings are expected to change significantly.
VRTX appears fairly valued according to analysts, with a "Buy" rating and minimal upside to the $545.08 target. Consider your investment thesis and risk tolerance. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
VRTX analyst price targets range from $441 to $607, a 30% moderate spread showing some variance in outlooks. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $545.08 consensus represents the middle ground. Our model's $27-$1613 range provides an independent fundamental perspective.