Vertex Pharmaceuticals Incorporated (VRTX) Price Target Analysis
Updated Jun 18, 2026
Analyst Rating: Buy
Based on 56 analysts22.7% Below Target
VRTX trades 22.7% below Wall Street's consensus target of $553.93.
Current Price$451.63
Average Target$553.93
Target
Current
Low$436.00
Median$558.00
High$616.00
Analyst Target Range
Forward P/E23.4x
(Fair)
PEG Ratio2.82
(Pricey)
Implied Growth+14.1%
(Moderate)
Analyst Spread32.5%
(Moderate)
Price Forecast (1 Year)
Last 12 months price action with 12-month analyst target path
Consensus Scenario Assumptions
The base valuation assumes VRTX achieves its forward estimates and maintains a stable P/E multiple of 23.4x. This scenario reflects the blended consensus of 56 Wall Street analysts, balancing both positive catalysts and macroeconomic headwinds over the next 12 months.
VRTX Price Target Analysis
Updated June 22, 2026As of June 22, 2026, Vertex Pharmaceuticals Incorporated (VRTX) has a Wall Street consensus price target of $553.93, based on estimates from 56 covering analysts. With the stock currently trading at $451.63, this represents a potential upside of +22.7%. The company has a market capitalization of $114.88B.
Analyst price targets range from a low of $436.00 to a high of $616.00, representing a 32% spread in expectations. The median target of $558.00 aligns closely with the consensus average.
The current analyst consensus rating is Buy, with 47 analysts rating the stock as a Buy or Strong Buy,9 rating it Hold, and 0 rating it Sell or Strong Sell. This overwhelmingly bullish sentiment suggests analysts see significant catalysts for upside ahead.
From a valuation perspective, VRTX trades at a trailing P/E of 29.5x and forward P/E of 23.4x. The forward PEG ratio of 2.82 reflects a premium valuation. Analysts expect EPS to grow +14.1% over the next year.
Our proprietary valuation model, which blends historical multiples with forward estimates, suggests a base-case price target of $589.17, with bear and bull scenarios of $371.17 and $776.29 respectively. Model confidence stands at 57/100, reflecting moderate uncertainty in projections.
Investment Context: Price targets represent analyst expectations for the next 12 months and should be considered alongside your own research. Targets are based on analysts' assumptions about earnings growth, margins, and market conditions which may change. For sector-specific context, view other Healthcare stocks.
Analyst Sentiment Comparison
Industry Peer AnalysisAvg Peer Upside
+35.6%
Industry Consensus
Avg Forward P/E
15.8x
(Fair)
Peers with Coverage
10 / 10
Active Analyst Tracking
| Company | Market Cap | Price | Target | Upside Potential | Rating | Fwd P/E | Analysts |
|---|---|---|---|---|---|---|---|
 REGNRegeneron Pharmaceuticals, Inc. | $63.4B | $609.94 | $836.00 | +37.1% | Buy | 13.1x | 48 |
 ALNYAlnylam Pharmaceuticals, Inc. | $37.1B | $278.09 | $454.27 | +63.4% | Buy | 37.1x | 52 |
 BMRNBioMarin Pharmaceutical Inc. | $10.5B | $54.69 | $89.93 | +64.4% | Buy | 11.1x | 41 |
 SRPTSarepta Therapeutics, Inc. | $1.9B | $17.53 | $25.14 | +43.4% | Buy | 5.0x | 54 |
 RAREUltragenyx Pharmaceutical Inc. | $2.7B | $27.44 | $48.36 | +76.2% | Buy | — | 33 |
 IONSIonis Pharmaceuticals, Inc. | $12.2B | $74.12 | $109.44 | +47.7% | Buy | — | 32 |
 ABBVAbbVie Inc. | $383.2B | $216.63 | $256.92 | +18.6% | Buy | 15.2x | 41 |
 BIIBBiogen Inc. | $29.0B | $196.58 | $218.32 | +11.1% | Buy | 13.5x | 48 |
 GILDGilead Sciences, Inc. | $153.7B | $123.76 | $161.81 | +30.7% | Buy | — | 58 |
 MRNAModerna, Inc. | $25.4B | $63.96 | $40.29 | -37.0% | Hold | — | 27 |
VRTX — Frequently Asked Questions
Quick answers to the most common questions about buying VRTX stock.
What is the VRTX stock price target for 2026?
The consensus Wall Street price target for VRTX is $553.93, representing 22.7% upside from the current price of $451.63. With 56 analysts covering the stock, this strong upside suggests significant value not yet reflected in today's share price.
Is VRTX a buy, sell, or hold?
VRTX has a consensus rating of "Buy" based on 56 Wall Street analysts. The rating breakdown is predominantly bullish, with 47 Buy/Strong Buy ratings. The consensus 12-month price target of $553.93 implies 22.7% upside from current levels.
Is VRTX stock overvalued or undervalued?
VRTX trades at a forward P/E of 23.3934x, representing a moderate valuation. With analysts targeting $553.93 (22.7% implied move), the stock appears reasonably valued with upside.
How high can VRTX stock go?
The most bullish Wall Street analyst has a price target of $616 for VRTX, while the most conservative target is $436. The consensus of $553.93 represents the median expectation. Our quantitative valuation model projects a bull case target of $776 based on optimistic growth and margin assumptions. These targets typically reflect 12-month expectations.
How many analysts cover VRTX stock?
VRTX is heavily covered by Wall Street, with 56 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 47 have Buy ratings, 9 recommend Hold, and 0 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
What is the VRTX stock forecast?
The 12-month VRTX stock forecast based on 56 Wall Street analysts shows a consensus price target of $553.93, with estimates ranging from $436 (bear case) to $616 (bull case). The median consensus rating is "Buy". Our proprietary valuation model produces a base case fair value of $589, with bear/bull scenarios of $371/$776.
What is VRTX's fair value based on fundamentals?
Our quantitative valuation model calculates VRTX's fair value at $589 (base case), with a bear case of $371 and bull case of $776. The model uses discounted cash flow analysis, historical growth rates, and margin mean-reversion to project FY+2 earnings, then applies an appropriate P/E multiple. The model confidence score is 57/100.
What is VRTX's forward P/E ratio?
VRTX trades at a forward P/E ratio of 23.4x based on next-twelve-months earnings estimates compared to a trailing P/E of 29.5x. The lower forward P/E indicates analysts expect earnings growth. A forward P/E is useful for comparing valuations when earnings are expected to change significantly.
Should I buy VRTX stock?
Wall Street analysts are very optimistic on VRTX, with a "Buy" consensus rating and $553.93 price target (22.7% upside). 47 of 56 analysts rate it Buy or Strong Buy. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
Why do VRTX price targets vary so much?
VRTX analyst price targets range from $436 to $616, a 32% moderate spread showing some variance in outlooks. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $553.93 consensus represents the middle ground. Our model's $371-$776 range provides an independent fundamental perspective.
Consensus-Based Analysis Tools
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