Last 48 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
EV/EBITDA has compressed 96.3% YoY to 2.5x, reflecting multiple compression or accelerating EBITDA.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -10.30 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | — | — | 10.39 | 3.35 | 5.99 | 6.00 | 18.09 | 17.21 | 21.17 | 6.34 | 5.16 | 8.20 | 21.98 |
| — | — | -42.5% | -80.6% | -71.7% | -5.2% | +250.4% | +109.8% | -3.7% | -64.9% | -63.7% | -39.3% | +361.2% | |
| P/B Ratio | 0.75 | 0.89 | 1.40 | 0.94 | 1.22 | 2.49 | 1.79 | 2.08 | 2.26 | 1.95 | 1.83 | 2.20 | 2.44 |
| — | -64.2% | -21.8% | -54.7% | -45.8% | +27.9% | -2.2% | -5.7% | -7.4% | -9.0% | -14.9% | +0.2% | +14.2% | |
| P/FCF | — | — | — | — | — | — | — | — | — | 18.79 | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | 2.48 | — | — | — | 66.49 | — | — | — | — | — | — | — |
| — | -96.3% | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | 4.73 | 159.80 | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Xencor, Inc.'s operating margin was -127.3% in Q4 2025, up 99.0 pp QoQ and down 133.0 pp YoY. The trailing four-quarter average of -140.4% lags the current quarter, suggesting the recent improvement is above-trend. Gross margin contracted 5.5% YoY, suggesting cost inflation or competitive pricing pressure.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | 94.5% | 100.0% | 93.9% | 91.8% | 100.0% | 100.0% | 82.2% | 100.0% | 93.7% | -9.8% | -31.9% | -245.7% |
| — | -5.5% | 0.0% | +14.3% | -8.2% | +6.8% | +1124.1% | +357.3% | +140.7% | +167.8% | +89.7% | +43.0% | -656.6% | |
| Operating Margin | — | -127.3% | -226.3% | -76.1% | -131.9% | 5.8% | -310.2% | -367.4% | -341.7% | -56.4% | -30.9% | -57.1% | -320.3% |
| — | -2301.8% | +27.0% | +79.3% | +61.4% | +110.3% | -904.4% | -543.4% | -6.7% | +71.4% | +78.0% | +38.5% | -1134.8% | |
| Net Margin | — | 6.8% | -28.7% | -70.7% | -147.9% | -76.4% | -260.1% | -388.9% | -459.1% | -51.3% | -41.0% | -48.2% | -320.4% |
| — | +108.9% | +89.0% | +81.8% | +67.8% | -48.9% | -534.1% | -706.5% | -43.3% | +7.9% | +65.8% | +57.2% | -1261.2% |
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -9.5% | -0.7% | -1.0% | -4.9% | -7.4% | -7.7% | -7.2% | -11.4% | -11.6% | -3.9% | -3.6% | -3.2% | -8.6% |
| — | +90.8% | +86.6% | +56.9% | +36.7% | -95.2% | -100.3% | -252.2% | -35.2% | -136.6% | +19.5% | +28.6% | -373.1% | |
| ROA | -10.1% | -0.8% | -0.7% | -3.5% | -5.2% | -5.5% | -5.1% | -7.7% | -7.9% | -3.0% | -3.1% | -2.8% | -7.4% |
| — | +86.2% | +86.5% | +54.9% | +33.9% | -84.2% | -64.0% | -175.8% | -7.1% | -109.4% | +19.7% | +30.2% | -364.8% | |
| ROIC | — | 8.9% | -4.9% | -3.8% | -4.2% | 0.4% | -5.9% | -6.5% | -4.9% | -2.8% | -2.0% | -2.8% | -6.5% |
| — | +2313.0% | +16.6% | +41.5% | +13.3% | +113.2% | -198.3% | -128.3% | +24.9% | +36.5% | +50.0% | +1.7% | -319.7% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
Xencor, Inc.'s Debt/EBITDA ratio is 0.6x — comfortably within a safe range. The current ratio has weakened 5.3% YoY to 6.25x, tightening the short-term liquidity position.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.05 | 0.05 | 0.32 | 0.11 | 0.11 | 0.34 | 0.12 | 0.16 | 0.42 | 0.38 | 0.09 | 0.09 | 0.09 |
| — | -84.5% | +169.5% | -29.7% | -75.0% | -9.6% | +32.3% | +79.8% | +388.7% | +364.2% | +52.3% | +54.7% | +89.5% | |
| Debt / EBITDA | — | 0.59 | — | — | — | 32.94 | — | — | — | — | — | — | — |
| — | -98.2% | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 6.25 | 6.25 | 5.99 | 5.34 | 5.89 | 6.61 | 6.23 | 6.92 | 8.09 | 8.60 | 10.77 | 13.30 | 9.68 |
| — | -5.3% | -3.8% | -22.9% | -27.1% | -23.2% | -42.1% | -47.9% | -16.5% | -18.7% | +45.1% | +70.3% | +16.6% | |
| Quick Ratio | 6.25 | 6.25 | 5.99 | 5.34 | 5.89 | 6.61 | 6.23 | 6.92 | 8.09 | 8.60 | 10.77 | 13.30 | 9.68 |
| — | -5.3% | -3.8% | -22.9% | -27.1% | -23.2% | -42.1% | -47.9% | -16.5% | -18.7% | +45.1% | +70.3% | +16.6% | |
| Interest Coverage | — | — | -6.20 | -4.02 | -4.98 | 0.12 | -69.43 | -73.84 | -5.65 | -4.65 | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 48 years · Updated daily
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Start ComparisonXencor, Inc.'s current P/E is -10.3x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Xencor, Inc.'s business trajectory between earnings reports.