Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in ZYME held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 23.0M | $600.4M | 0.0% | 31.221% | 29.19% |
| 2 | Rubric Capital Management LP | 7.0M | $183.0M | 0.0% | 9.514% | 1.68% |
| 3 | BlackRock, Inc. | 4.3M | $111.1M | -6.7% | 5.778% | 0.00% |
| 4 | PERCEPTIVE ADVISORS LLC | 4.2M | $109.3M | +19.2% | 5.685% | 1.64% |
| 5 | BVF INC/IL | 3.6M | $95.4M | -2.3% | 4.960% | 2.44% |
| 6 | MORGAN STANLEY | 2.2M | $58.3M | -10.1% | 3.033% | 0.00% |
| 7 | BNP Paribas Asset Management Holding S.A. | 1.8M | $46.6M | -6.7% | 2.421% | 0.05% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 1.6M | $40.8M | -8.6% | 2.119% | 0.00% |
| 9 | Assenagon Asset Management S.A. | 1.3M | $32.7M | +72.0% | 1.702% | 0.02% |
| 10 | Nextech Invest Ltd. | 1.1M | $29.1M | 0.0% | 1.514% | 1.38% |
| 11 | STATE STREET CORP | 1.1M | $28.4M | +7.5% | 1.479% | 0.00% |
| 12 | DIMENSIONAL FUND ADVISORS LP | 995K | $26.0M | -12.7% | 1.352% | 0.00% |
| 13 | CITADEL ADVISORS LLC | 966K | $25.3M | -22.7% | 1.313% | 0.00% |
| 14 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 890K | $23.3M | — | 1.209% | 0.03% |
| 15 | FMR LLC | 703K | $18.4M | +5.3% | 0.955% | 0.00% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 692K | $18.1M | +4.9% | 0.941% | 0.00% |
| 17 | Prosight Management, LP | 674K | $17.6M | +25.1% | 0.917% | 3.04% |
| 18 | Qube Research & Technologies Ltd | 594K | $15.5M | +16.0% | 0.807% | 0.01% |
| 19 | VANGUARD PORTFOLIO MANAGEMENT LLC | 510K | $13.3M | +2.0% | 0.693% | 0.00% |
| 20 | Redmile Group, LLC | 492K | $12.9M | 0.0% | 0.668% | 0.86% |
| 21 | Capricorn Fund Managers Ltd | 487K | $12.7M | -51.7% | 0.661% | 1.00% |
| 22 | GOLDMAN SACHS GROUP INC | 471K | $12.3M | -21.5% | 0.640% | 0.00% |
| 23 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 418K | $10.9M | -43.7% | 0.569% | 0.00% |
| 24 | DEUTSCHE BANK AG\ | 397K | $10.4M | -56.9% | 0.540% | 0.00% |
| 25 | Hillsdale Investment Management Inc. | 383K | $10.0M | +10.8% | 0.521% | 0.23% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in ZYME — a direct measure of their conviction.
Filings activity in ZYME during Q2 2026, grouped by how each filer changed its position.
Institutions that opened a new ZYME position in Q2 2026
Institutions that fully closed their ZYME position in Q2 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 202 | 6.0% | 93.01% | 0.76 pp | $1.78B | +1.5% |
| Q1 2026 | 215 | +3.9% | 93.77% | 0.12 pp | $1.76B | 4.2% |
| Q4 2025 | 207 | +14% | 93.89% | 2.32 pp | $1.83B | +46% |
| Q3 2025 | 181 | +0.6% | 96.21% | 2.07 pp | $1.26B | +38% |
| Q2 2025 | 180 | 2.2% | 98.28% | +0.29 pp | $916M | +14% |
| Q1 2025 | 184 | +6.4% | 97.99% | 32.95 pp | $801M | 41% |
| Q4 2024 | 173 | +6.1% | 130.94% | +37.75 pp | $1.36B | +70% |
| Q3 2024 | 163 | — | 93.19% | — | $799M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying ZYME stock.
Based on Q2 2026 13F filings, institutional ownership of Zymeworks Inc. stands at 93.0%, held across 202 reporting institutions.
EcoR1 Capital, LLC is the largest reported institutional holder of ZYME, with approximately 22,970,388 shares worth $0.60B as of Q2 2026.
Yes — 1 widely-followed marquee investor appear among the top 25 institutional holders of ZYME, including CITADEL ADVISORS LLC.
Our composite Smart Money Score for ZYME is 37 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
22 institutions opened new positions in ZYME during Q2 2026, while 32 fully exited. 107 added to existing positions and 69 trimmed.
ZYME institutional ownership fell by 0.76 percentage points quarter-over-quarter, with a net change of -13 holders.
The top 10 institutions account for 73.2% of all reported 13F value in ZYME, and the top 25 account for 87.5%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Zymeworks Inc. (ZYME) Institutional Ownership