| 4 | MORGAN STANLEY | 2.3M | $35.7M | -50.2% | 21.418% | 0.00% |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 2.2M | $33.8M | +1.6% | 20.244% | 0.00% |
| 6 | MILLENNIUM MANAGEMENT LLC | 1.7M | $27.1M | -41.9% | 16.225% | 0.01% |
| 7 | FRED ALGER MANAGEMENT, LLC | 1.5M | $24.3M | -9.1% | 14.537% | 0.08% |
| 8 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.5M | $24.1M | +86.6% | 14.448% | 0.00% |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $20.6M | +5.1% | 12.346% | 0.00% |
| 10 | MAK CAPITAL ONE LLC | 1.3M | $20.1M | -10.3% | 12.016% | 2.81% |
| 11 | First Eagle Investment Management, LLC | 1.3M | $20.0M | +70.7% | 11.960% | 0.02% |
| 12 | Assenagon Asset Management S.A. | 1.2M | $18.1M | -23.0% | 10.840% | 0.01% |
| 13 | STATE STREET CORP | 1.0M | $16.4M | +6.4% | 9.848% | 0.00% |
| 14 | JANE STREET GROUP, LLC | 1.0M | $16.3M | +5.7% | 9.755% | 0.00% |
| 15 | DIMENSIONAL FUND ADVISORS LP | 1.0M | $15.7M | +8.3% | 9.408% | 0.00% |
| 16 | Nuveen, LLC | 923K | $14.5M | +817.3% | 8.682% | 0.00% |
| 17 | UBS Group AG | 868K | $13.6M | -6.9% | 8.168% | 0.00% |
| 18 | SILVERCREST ASSET MANAGEMENT GROUP LLC | 859K | $13.5M | -4.7% | 8.078% | 0.09% |
| 19 | Meros Investment Management, LP | 743K | $11.7M | +22.0% | 6.992% | 3.70% |
| 20 | NEEDHAM INVESTMENT MANAGEMENT LLC | 717K | $11.3M | +99.2% | 6.745% | 0.34% |
| 21 | BROWN CAPITAL MANAGEMENT LLC | 670K | $10.5M | -14.2% | 6.303% | 2.10% |
| 22 | DEUTSCHE BANK AG\ | 655K | $10.3M | -34.6% | 6.161% | 0.00% |
| 23 | Intrinsic Edge Capital Management LLC | 630K | $9.9M | 0.0% | 5.926% | 1.02% |
| 24 | BNP Paribas Asset Management Holding S.A. | 575K | $9.0M | -26.1% | 5.412% | 0.01% |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 563K | $8.8M | +9.6% | 5.295% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in CYRX — a direct measure of their conviction.
| 91.37% |
| 3.71 pp |
| $262M |
| 25% |
| Q4 2024 | 159 | +7.4% | 95.08% | +0.22 pp | $350M | 2.3% |
| Q3 2024 | 148 | — | 94.86% | — | $358M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
33 institutions opened new positions in CYRX during Q2 2026, while 15 fully exited. 137 added to existing positions and 9 trimmed.
CYRX institutional ownership rose by 104.19 percentage points quarter-over-quarter, with a net change of +21 holders.
The top 10 institutions account for 88.1% of all reported 13F value in CYRX, and the top 25 account for 93.6%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.