Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in DYN held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON GROUP PLC | 13.6M | $247.4M | -1.7% | 8.260% | 0.12% |
| 2 | BlackRock, Inc. | 11.7M | $212.1M | +4.5% | 7.081% | 0.00% |
| 3 | Atlas Venture Life Science Advisors, LLC | 9.1M | $165.5M | 0.0% | 5.526% | 20.95% |
| 4 | FMR LLC | 8.9M | $161.5M | +35.6% | 5.392% | 0.01% |
| 5 | Orbis Allan Gray Ltd | 6.8M | $122.6M | +40.8% | 4.093% | 0.52% |
| 6 | STATE STREET CORP | 6.7M | $120.6M | -0.6% | 4.027% | 0.00% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 6.4M | $116.1M | — | 3.877% | 0.00% |
| 8 | PERCEPTIVE ADVISORS LLC | 4.7M | $84.6M | +34.2% | 2.826% | 1.67% |
| 9 | FCPM III SERVICES B.V. | 4.6M | $84.2M | -15.0% | 2.811% | 11.66% |
| 10 | TCG Crossover Management, LLC | 4.6M | $83.7M | 0.0% | 2.793% | 2.39% |
| 11 | VANGUARD PORTFOLIO MANAGEMENT LLC | 4.2M | $75.5M | — | 2.519% | 0.00% |
| 12 | Vestal Point Capital, LP | 4.0M | $72.5M | +3233.3% | 2.421% | 2.03% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 3.5M | $63.5M | +7.4% | 2.121% | 0.00% |
| 14 | ARMISTICE CAPITAL, LLC | 3.2M | $57.6M | -2.3% | 1.922% | 1.70% |
| 15 | Frazier Life Sciences Management, L.P. | 3.2M | $57.2M | 0.0% | 1.908% | 1.47% |
| 16 | ORBIMED ADVISORS LLC | 2.9M | $52.9M | +32.5% | 1.766% | 1.11% |
| 17 | Siren, L.L.C. | 2.2M | $40.4M | -36.4% | 1.349% | 1.12% |
| 18 | VR Adviser, LLC | 2.2M | $39.4M | 0.0% | 1.316% | 1.47% |
| 19 | FRANKLIN RESOURCES INC | 2.0M | $36.4M | +0.1% | 1.216% | 0.01% |
| 20 | Deep Track Capital, LP | 2.0M | $36.3M | -24.5% | 1.210% | 0.75% |
| 21 | SAMLYN CAPITAL, LLC | 1.9M | $34.9M | +28.8% | 1.164% | 0.60% |
| 22 | GOLDMAN SACHS GROUP INC | 1.7M | $31.2M | -24.5% | 1.043% | 0.00% |
| 23 | BRAIDWELL LP | 1.7M | $30.5M | +13.8% | 1.018% | 1.02% |
| 24 | Palo Alto Investors LP | 1.7M | $30.0M | +12.3% | 1.000% | 4.58% |
| 25 | Sofinnova Investments, Inc. | 1.6M | $29.6M | -27.5% | 0.989% | 1.55% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in DYN — a direct measure of their conviction.
Filings activity in DYN during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 227 | 0.4% | 91.16% | 11.21 pp | $2.74B | 11% |
| Q4 2025 | 228 | +12% | 102.37% | +38.72 pp | $3.08B | +61% |
| Q3 2025 | 204 | +3.6% | 63.65% | +24.56 pp | $1.91B | +63% |
| Q2 2025 | 197 | 3.0% | 39.09% | 1.12 pp | $1.17B | 2.8% |
| Q1 2025 | 203 | +3.0% | 40.21% | 42.89 pp | $1.21B | 52% |
| Q4 2024 | 197 | 2.0% | 83.10% | 43.74 pp | $2.50B | 34% |
| Q3 2024 | 201 | +4.1% | 126.84% | +5.22 pp | $3.81B | +4.3% |
| Q2 2024 | 193 | — | 121.62% | — | $3.66B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying DYN stock.
Based on Q1 2026 13F filings, institutional ownership of Dyne Therapeutics, Inc. stands at 91.2%, held across 227 reporting institutions.
JANUS HENDERSON GROUP PLC is the largest reported institutional holder of DYN, with approximately 13,647,376 shares worth $0.25B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of DYN.
Our composite Smart Money Score for DYN is 23 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
46 institutions opened new positions in DYN during Q1 2026, while 47 fully exited. 69 added to existing positions and 111 trimmed.
DYN institutional ownership fell by 11.21 percentage points quarter-over-quarter, with a net change of -1 holders.
The top 10 institutions account for 51.0% of all reported 13F value in DYN, and the top 25 account for 76.2%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Dyne Therapeutics, Inc. (DYN) Institutional Ownership