Last 46 quarters of trend data · Healthcare · Medical - Pharmaceuticals
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -21.35 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 48.06 | 53.48 | 44.34 | 37.16 | 29.58 | 33.94 | 28.68 | 13.34 | 13.40 | 11.41 | 9.40 | 8.91 | 11.18 |
| — | +57.6% | +54.6% | +178.6% | +120.7% | +197.5% | +205.3% | +49.6% | +19.9% | +18.8% | +3.9% | -32.3% | -22.3% | |
| P/B Ratio | 36.92 | 32.20 | 15.24 | 139.15 | 43.31 | 26.23 | 267.02 | — | — | — | — | — | 30.14 |
| — | +22.8% | -94.3% | — | — | — | — | — | — | — | — | — | +283.3% | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Insmed Incorporated's operating margin was -298.4% in Q3 2025, down 7.1 pp QoQ and down 69.9 pp YoY. This marks the 4th consecutive quarter of margin compression, signaling a persistent pressure on profitability that investors should monitor. The trailing four-quarter average of -269.4% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind. Gross margin contracted 24.0% YoY, suggesting cost inflation or competitive pricing pressure.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 79.7% | 58.7% | 73.9% | 77.1% | 75.0% | 77.3% | 76.8% | 76.9% | 78.0% | 78.9% | 78.5% | 78.8% | 78.0% |
| — | -24.0% | -3.8% | +0.3% | -3.9% | -1.9% | -2.2% | -2.4% | +0.0% | -1.5% | +4.9% | +2.3% | +2.1% | |
| Operating Margin | -205.6% | -298.4% | -291.3% | -267.3% | -220.6% | -228.4% | -319.8% | -192.7% | -213.0% | -186.8% | -305.0% | -227.2% | -255.4% |
| — | -30.6% | +8.9% | -38.7% | -3.6% | -22.3% | -4.9% | +15.2% | +16.6% | +0.9% | -125.2% | -34.3% | -44.7% | |
| Net Margin | -210.5% | -260.0% | -299.5% | -276.4% | -225.5% | -236.0% | -332.8% | -208.1% | -222.3% | -201.0% | -317.0% | -245.0% | -270.0% |
| — | -10.1% | +10.0% | -32.9% | -1.4% | -17.4% | -5.0% | +15.1% | +17.7% | -3.8% | -116.2% | -37.5% | -34.1% |
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -249.3% | -33.7% | -47.7% | -133.4% | -61.3% | -84.5% | -774.4% | — | — | — | — | -738.0% | -552.2% |
| — | +60.1% | +93.8% | — | — | — | — | — | — | — | — | -1968.2% | -2137.0% | |
| ROA | -59.5% | -15.3% | -15.0% | -13.4% | -11.6% | -11.4% | -20.2% | -12.6% | -14.0% | -11.5% | -16.6% | -10.1% | -12.1% |
| — | -33.9% | +25.8% | -6.2% | +17.6% | +0.7% | -22.3% | -25.4% | -16.0% | +10.2% | -91.0% | -27.5% | -36.6% | |
| ROIC | -141.8% | -30.9% | -27.4% | -18.2% | -15.5% | -23.6% | -90.0% | -25.4% | -27.6% | -26.4% | -59.9% | -61.2% | -39.4% |
| — | -30.8% | +69.6% | +28.6% | +43.9% | +10.6% | -50.3% | +58.5% | +29.9% | -16.2% | -306.3% | -239.2% | -49.8% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 27.3% YoY to 4.63x, tightening the short-term liquidity position.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.06 | 0.79 | 0.59 | 13.21 | 4.60 | 2.41 | 35.53 | — | — | — | — | — | 13.39 |
| — | -67.3% | -98.3% | — | — | — | — | — | — | — | — | — | +797.8% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 3.83 | 4.63 | 6.68 | 5.86 | 5.45 | 6.37 | 2.71 | 1.80 | 4.12 | 4.71 | 5.15 | 6.01 | 6.69 |
| — | -27.3% | +146.8% | +225.2% | +32.4% | +35.1% | -47.5% | -70.0% | -38.5% | +2.6% | -13.1% | -0.5% | +8.1% | |
| Quick Ratio | 3.54 | 4.34 | 6.33 | 5.44 | 5.12 | 5.99 | 2.53 | 1.61 | 3.75 | 4.31 | 4.77 | 5.63 | 6.33 |
| — | -27.5% | +149.9% | +238.9% | +36.6% | +38.8% | -46.9% | -71.5% | -40.7% | +4.9% | -10.6% | +1.8% | +11.0% | |
| Interest Coverage | — | -20.84 | -14.73 | -11.50 | -10.69 | -10.14 | -13.58 | -6.91 | -8.58 | -7.28 | -11.42 | -7.41 | -9.21 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 46 years · Updated daily
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Start ComparisonQuick answers to the most common questions about buying INSM stock.
Insmed Incorporated's current P/E is -21.4x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Insmed Incorporated's current operating margin is -205.6%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Insmed Incorporated's business trajectory between earnings reports.