Last 46 quarters of trend data · Healthcare · Rare Disease Biotech
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | — | 14.19 | 14.47 | 35.96 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | — | 4.70 | 6.86 | 14.06 | 32.38 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/B Ratio | — | 3.58 | 5.59 | 7.50 | 17.61 | 14.21 | 8.06 | 7.99 | 5.61 | 10.81 | 6.73 | 14.53 | 17.99 | 38.30 | 9.03 | 5.17 | 6.39 | 3.38 | 9.21 | 18.27 | 16.57 |
| — | -74.8% | -30.6% | -6.1% | +213.7% | +31.4% | +19.6% | -45.0% | -68.8% | -71.8% | -25.4% | +180.9% | +181.5% | +1034.3% | -1.9% | -71.7% | -61.4% | -74.7% | -45.4% | -12.2% | +81.3% | |
| P/FCF | — | 17.12 | 12.93 | 21.27 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | 12.77 | 14.95 | 38.36 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | 11.38 | 13.69 | 31.65 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | 98.7% | 99.1% | 98.3% | 97.9% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Operating Margin | — | 33.6% | 44.1% | 33.5% | -20.0% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Net Margin | — | 33.2% | 47.3% | 39.4% | -14.4% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | — | 6.6% | 9.2% | 7.1% | -2.0% | -18.3% | -22.0% | -28.1% | -10.3% | -14.2% | -12.5% | -60.9% | -112.5% | -128.7% | -42.9% | -34.5% | -28.8% | -25.9% | -14.9% | -34.2% | -33.8% |
| — | +136.2% | +141.8% | +125.2% | +80.7% | -28.9% | -75.7% | +53.9% | +90.8% | +88.9% | +70.9% | -76.4% | -291.2% | -397.4% | -188.5% | -1.1% | +14.9% | -20.1% | -144.1% | -108.3% | -50.3% | |
| ROA | — | 5.4% | 7.5% | 5.6% | -1.4% | -13.5% | -17.8% | -25.5% | -9.2% | -12.2% | -9.3% | -23.0% | -33.6% | -36.3% | -18.8% | -17.8% | -16.9% | -14.7% | -7.2% | -17.8% | -20.8% |
| — | +139.7% | +141.8% | +121.9% | +84.3% | -10.2% | -92.8% | -10.9% | +72.5% | +66.3% | +50.7% | -29.0% | -98.2% | -147.7% | -159.2% | +0.0% | +18.7% | +0.4% | -73.6% | -57.1% | -56.5% | |
| ROIC | — | 6.4% | 9.6% | 7.1% | -2.3% | -16.6% | -20.7% | -27.1% | -10.7% | -39.5% | — | — | — | — | — | — | — | — | — | — | — |
| — | +138.3% | +146.3% | +126.1% | +78.3% | +58.0% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | 0.01 | 0.01 | 0.01 | 0.22 | 0.23 | 0.22 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.04 | 0.01 | 0.01 | 0.02 | 0.02 | 0.02 | 0.03 | 0.03 | 0.02 |
| — | -96.1% | -97.2% | -50.4% | +20748.5% | +9292.8% | +8321.9% | -43.5% | -97.3% | -83.6% | -82.9% | +28.7% | +135.2% | -7.6% | -41.7% | -43.7% | -17.5% | +953.8% | +741.5% | +509.1% | +279.2% | |
| Debt / EBITDA | — | 0.14 | 0.07 | 0.12 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | — | 5.62 | 5.80 | 16.08 | 15.13 | 19.64 | 15.68 | 17.26 | 29.24 | 11.23 | 14.89 | 1.85 | 2.33 | 1.18 | 2.14 | 2.80 | 3.43 | 4.10 | 2.80 | 3.19 | 4.13 |
| — | -71.4% | -63.0% | -6.8% | -48.3% | +74.8% | +5.3% | +832.4% | +1154.8% | +855.1% | +596.1% | -33.9% | -32.2% | -71.3% | -23.6% | -12.3% | -16.9% | -8.3% | -52.0% | -54.8% | -45.2% | |
| Quick Ratio | — | 5.32 | 5.55 | 15.88 | 15.01 | 19.64 | 15.68 | 17.26 | 29.24 | 11.23 | 14.89 | 1.85 | 2.33 | 1.18 | 2.14 | 2.80 | 3.43 | 4.10 | 2.80 | 3.19 | 4.13 |
| — | -72.9% | -64.6% | -8.0% | -48.6% | +74.8% | +5.3% | +832.4% | +1154.8% | +855.1% | +596.1% | -33.9% | -32.2% | -71.3% | -23.6% | -12.3% | -16.9% | -8.3% | -52.0% | -54.8% | -45.2% | |
| Interest Coverage | — | 28.02 | 33.14 | 19.71 | -2.42 | -31.16 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 46 years · Updated daily
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Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Soleno Therapeutics, Inc.'s business trajectory between earnings reports.