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SLNOSoleno Therapeutics, Inc.
$53.01$2.8B
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SLNO logoSoleno Therapeutics, Inc.(SLNO)Earnings, Financials & Key Ratios

SLNO•NASDAQ
135.9× P/E·Price updated Jun 1, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutSoleno Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of novel therapeutics for the treatment of rare diseases. Its lead candidate is Diazoxide Choline Controlled-Release, a once-daily oral tablet for the treatment of Prader-Willi Syndrome, which is being evaluated in an ongoing Phase III clinical development program. The company was formerly known as Capnia, Inc. and changed its name to Soleno Therapeutics, Inc. in May 2017. Soleno Therapeutics, Inc. was incorporated in 1999 and is based in Redwood City, California.Show more
  • Revenue$190M
  • EBITDA$17M+109.1%
  • Net Income$21M+111.9%
  • EPS (Diluted)0.39+108.9%
  • Gross Margin98.58%
  • EBITDA Margin8.91%
  • Operating Margin7.85%
  • Net Margin10.97%
  • ROE6.01%+106.9%

SLNO Key Insights

Soleno Therapeutics, Inc. (SLNO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Strong Piotroski F-Score: 7/9
  • ✓FCF machine: 24.5% free cash flow margin
  • ✓Momentum leader: RS Rating 85 (top 15%)
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Healthy 5Y average net margin of 11.0%

✗Weaknesses

  • ✗Shares diluted 35.2% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SLNO Price & Volume

Soleno Therapeutics, Inc. (SLNO) stock price & volume — 10-year historical chart

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SLNO Growth Metrics

Soleno Therapeutics, Inc. (SLNO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years85.84%
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM148.45%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM138.24%

Return on Capital

10 Years-83.4%
5 Years-59.56%
3 Years-39.41%
Last Year3.67%

SLNO Recent Earnings

Soleno Therapeutics, Inc. (SLNO) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)●Beat Revenue 2/12 qtrs (50%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.59-19.2%
$0.73
Rev
$95M+0.9%
$94M
Q1 2026
Feb 25, 2026
Metric
Actual
Est
EPS
$0.80+25.0%
$0.64
Rev
$92M+3.4%
$89M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.47+717.4%
$0.06
Rev
$66M-25.4%
$89M
Q3 2025
Aug 6, 2025
Metric
Actual
Est
EPS
$0.09+83.0%
$0.53
Rev
$33M-17.0%
$39M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.59vs $0.73-19.2%
$95Mvs $94M+0.9%
Q1 2026Feb 25, 2026
$0.80vs $0.64+25.0%
$92Mvs $89M+3.4%
Q4 2025Nov 4, 2025
$0.47vs $0.06+717.4%
$66Mvs $89M-25.4%
Q3 2025Aug 6, 2025
$0.09vs $0.53+83.0%
$33Mvs $39M-17.0%
Based on last 12 quarters of dataView full earnings history →

SLNO Peer Comparison

Soleno Therapeutics, Inc. (SLNO) competitors in Commercial Rare Disease Biopharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.7B27.44-4.7120.13%-91.03%-6.08%
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
RYTM logoRYTMRhythm Pharmaceuticals, Inc.Direct Competitor6.63B96.79-31.1245.83%-93.84%-204.35%1.77
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Direct Competitor11.66B505.75-39.36432.05%-27.32%-50.15%0.59
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor6.55B78.9810.15114.51%-22.58%
ANAB logoANABAnaptysBio, Inc.Product Competitor2.48B57.51-125.02157.01%-11.53%-24.49%0.38
FOLD logoFOLDAmicus Therapeutics, Inc.Product Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76
KRYS logoKRYSKrystal Biotech, Inc.Product Competitor10.26B348.0650.8933.94%53.92%19.25%0.01

Compare SLNO vs Peers

Soleno Therapeutics, Inc. (SLNO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for SLNO.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SLNO against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, ACAD, RYTM, MDGL

SLNO Income Statement

Soleno Therapeutics, Inc. (SLNO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
-1.55B0000000190.41M285.01M
Revenue Growth %
-107145.41%100%--------
Cost of Goods Sold
1.61M1.92M2.3M2.19M00002.7M3.9M
COGS % of Revenue
-0.1%-------1.42%-
Gross Profit
-1.55B▲ 0%
-1.92M▲ 99.9%
-2.3M▼ 19.7%
-2.19M▲ 4.5%
0▲ 100.0%
0▲ 0%
0▲ 0%
0▲ 0%
187.71M▲ 0%
281.11M▲ 0%
Gross Margin %
100.1%-------98.58%98.63%
Gross Profit Growth %
-2656540.69%99.88%-19.7%4.48%100%-----
Operating Expenses
9.68M13.73M20.9M29.75M31.53M24.4M41.38M187.67M172.75M193.34M
OpEx % of Revenue
-0.62%-------90.73%-
Selling, General & Admin
6.61M6.56M4.63M6.56M10.81M9.84M13.48M105.86M132.13M153.24M
SG&A % of Revenue
-0.43%-------69.39%-
Research & Development
3.07M7.18M16.27M23.19M21.45M15.27M25.19M78.57M40.63M38.38M
R&D % of Revenue
-0.2%-------21.34%-
Other Operating Expenses
-585.95K6K00-731K-712K2.71M3.24M01.61M
Operating Income
-12.17M▲ 0%
-14.3M▼ 17.5%
-23.2M▼ 62.2%
-31.95M▼ 37.7%
-31.53M▲ 1.3%
-24.4M▲ 22.6%
-41.38M▼ 69.6%
-187.67M▼ 353.5%
14.95M▲ 108.0%
87.77M▲ 0%
Operating Margin %
0.78%-------7.85%30.8%
Operating Income Growth %
10.57%-17.5%-62.21%-37.73%1.32%22.62%-69.63%-353.49%107.97%-
EBITDA
-10.56M-12.38M-20.9M-29.75M-29.57M-22.43M-39.43M-185.68M16.97M89.8M
EBITDA Margin %
0.68%-------8.91%31.51%
EBITDA Growth %
22.3%-17.25%-68.79%-42.37%0.64%24.12%-75.75%-370.97%109.14%143.53%
D&A (Non-Cash Add-back)
1.61M1.92M2.3M2.19M1.96M1.96M1.96M1.99M2.02M2.03M
EBIT
-13.44M-13.73M-30.77M-24.64M-32.26M-24.07M-38.99M-175.62M26.37M100.54M
Net Interest Income
00154K13K110K300K2.58M11.82M11.48M13.14M
Interest Income
00154K13K110K300K2.58M12.05M16.95M18.55M
Interest Expense
062K00000231K5.48M5.41M
Other Income/Expense
-1.27M2.46M-7.58M7.31M618K330K2.4M11.82M5.94M11.8M
Pretax Income
-13.72M▲ 0%
-11.84M▲ 13.7%
-30.77M▼ 159.9%
-24.64M▲ 19.9%
-30.91M▼ 25.5%
-24.07M▲ 22.1%
-38.99M▼ 62.0%
-175.85M▼ 351.0%
20.89M▲ 111.9%
99.58M▲ 0%
Pretax Margin %
0.88%-------10.97%34.94%
Income Tax
-1.65M000000003.54M
Effective Tax Rate %
12.03%0%0%0%0%0%0%0%0%3.55%
Net Income
-15.67M▲ 0%
-13.34M▲ 14.9%
-30.77M▼ 130.8%
-24.64M▲ 19.9%
-30.91M▼ 25.5%
-24.07M▲ 22.1%
-38.99M▼ 62.0%
-175.85M▼ 351.0%
20.89M▲ 111.9%
96.04M▲ 0%
Net Margin %
1.01%-------10.97%33.7%
Net Income Growth %
-29.86%14.89%-130.78%19.94%-25.45%22.14%-62%-351.04%111.88%148.45%
Net Income (Continuing)
-11.79M-11.84M-30.77M-24.64M-30.91M-24.07M-38.99M-175.85M20.89M96.04M
Discontinued Operations
-3.59M-1.49M00000000
Minority Interest
0000000000
EPS (Diluted)
-26.18▲ 0%
-9.54▲ 63.6%
-15.78▼ 65.4%
-3.68▲ 76.7%
-5.81▼ 57.9%
-2.87▲ 50.6%
-2.36▲ 17.8%
-4.38▼ 85.6%
0.39▲ 108.9%
1.81▲ 0%
EPS Growth %
55.13%63.56%-65.41%76.68%-57.88%50.6%17.77%-85.59%108.9%138.24%
EPS (Basic)
-26.18-9.54-15.78-3.68-5.81-2.87-2.36-4.380.41-
Diluted Shares Outstanding
598.52K1.4M2.28M4.17M5.32M8.4M16.49M40.18M54.33M53.07M
Basic Shares Outstanding
598.52K1.4M2.28M4.17M5.32M8.4M16.49M40.18M53.18M52.09M
Dividend Payout Ratio
----------

SLNO Balance Sheet

Soleno Therapeutics, Inc. (SLNO) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
17.99M24.67M21.14M50.24M22.42M15.65M171.36M293.89M355.81M326.38M
Cash & Short-Term Investments
17.1M24.08M20.73M49.22M21.3M14.6M169.68M291.44M305.47M255.6M
Cash Only
17.1M23.1M20.73M49.22M21.3M14.6M169.68M87.93M70.11M133.03M
Short-Term Investments
0978K00000203.51M235.37M122.57M
Accounts Receivable
064K00000028.21M47.14M
Days Sales Outstanding
--------54.0740.17
Inventory
0000000015.02M17.31M
Days Inventory Outstanding
--------2.03K968.24
Other Current Assets
551K00001.04M1.68M2.45M7.11M6.33M
Total Non-Current Assets
21.03M18.48M17.03M14.74M13.13M10.85M9.33M37.08M208.02M282.01M
Property, Plant & Equipment
22.89K12K444K158K454K157K419K2.98M2.38M4.09M
Fixed Asset Turnover
-67861.13x-------80.14x98.85x
Goodwill
125.53K000000000
Intangible Assets
20.41M18.47M16.52M14.58M12.64M10.69M8.75M6.8M4.86M4.37M
Long-Term Investments
000000027.21M064.15M
Other Non-Current Assets
591.92K059K040K0165K83K200.78M273.55M
Total Assets
39.02M▲ 0%
43.15M▲ 10.6%
38.17M▼ 11.5%
64.98M▲ 70.2%
35.55M▼ 45.3%
26.5M▼ 25.5%
180.69M▲ 581.9%
330.97M▲ 83.2%
563.83M▲ 70.4%
608.39M▲ 0%
Asset Turnover
-39.80x-------0.34x0.54x
Asset Growth %
601.22%10.58%-11.54%70.23%-45.29%-25.47%581.93%83.17%70.36%273.07%
Total Current Liabilities
1.73M1.88M4.96M8.62M8.01M7.31M11.51M18.75M61.36M58.05M
Accounts Payable
633K934K2M3.49M3.25M1.78M3.15M8.88M12.44M12.39M
Days Payables Outstanding
143.42177.65317.01580.44----1.68K917.23
Short-Term Debt
00000000726K1.16M
Deferred Revenue (Current)
0000000000
Other Current Liabilities
127K623K665K1.2M1.05M2.16M4.95M9.34M48.2M44.5M
Current Ratio
10.38x13.14x4.26x5.83x2.80x2.14x14.89x15.68x5.80x5.62x
Quick Ratio
10.38x13.14x4.26x5.83x2.80x2.14x14.89x15.68x5.55x5.32x
Cash Conversion Cycle
--------404.0791.18
Total Non-Current Liabilities
10.75M10.86M18.26M10.82M9.75M8.84M11.68M67.11M52.35M54.54M
Long-Term Debt
000000049.83M1.96M3.24M
Capital Lease Obligations
0000175K0130K2.47M02.25M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
10.47M10.86M18.26M10.82M9.58M8.84M11.55M14.81M50.39M51.3M
Total Liabilities
12.49M12.74M23.23M19.43M17.76M16.15M23.18M85.86M113.72M112.59M
Total Debt
00305K139K457K155K403K52.83M2.69M4.41M
Net Debt
-17.1M-23.1M-20.43M-49.09M-20.85M-14.45M-169.28M-35.1M-67.42M-128.62M
Debt / Equity
--0.02x0.00x0.03x0.01x0.00x0.22x0.01x0.01x
Debt / EBITDA
--------0.16x0.05x
Net Debt / EBITDA
---------3.97x-1.43x
Interest Coverage
--221.52x------760.26x4.81x18.59x
Total Equity
26.53M▲ 0%
30.41M▲ 14.6%
14.95M▼ 50.9%
45.55M▲ 204.7%
17.79M▼ 60.9%
10.35M▼ 41.8%
157.51M▲ 1422.1%
245.11M▲ 55.6%
450.12M▲ 83.6%
495.8M▲ 0%
Equity Growth %
672.44%14.62%-50.85%204.72%-60.93%-41.84%1422.1%55.62%83.64%269.57%
Book Value per Share
44.3321.756.5710.913.351.239.556.108.289.34
Total Shareholders' Equity
26.53M30.41M14.95M45.55M17.79M10.35M157.51M245.11M450.12M495.8M
Common Stock
19.24K32K45K80K80K8K32K46K52K52K
Retained Earnings
-113.98M-127.03M-157.81M-182.44M-213.35M-237.42M-276.41M-452.26M-431.37M-399.99M
Treasury Stock
0000000000
Accumulated OCI
-73.65K-93K00000361K415K-1.84M
Minority Interest
0000000000

SLNO Cash Flow Statement

Soleno Therapeutics, Inc. (SLNO) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-9.95M-11.68M-17.38M-25.22M-27.77M-20.78M-24.94M-69.1M46.8M105.71M
Operating CF Margin %
0.64%-------24.58%-
Operating CF Growth %
26.29%-17.42%-48.72%-45.17%-10.09%25.17%-20.01%-177.05%167.73%903.23%
Net Income
-12.07M-11.84M-30.77M-24.64M-30.91M-24.07M-38.99M-175.85M20.89M96.04M
Depreciation & Amortization
1.61M1.96M1.96M1.95M1.96M1.96M1.96M1.99M2.02M2.03M
Stock-Based Compensation
880.03K988K825K1.5M3.28M2.53M5.95M99.96M45.85M21.17M
Deferred Taxes
-1.65M-3.88M6.96M-11.64M000000
Other Non-Cash Items
1.31M1M1.15M4.62M-951K-452K3.22M-1.21M2.68M27.11M
Working Capital Changes
-24.07K82K2.5M2.98M-1.15M-756K2.93M6.02M-24.63M-40.64M
Change in Receivables
0-64K64K00000-28.21M-47.14M
Change in Inventory
00-64K00000-14.03M-15.86M
Change in Payables
190.63K249K1.06M1.49M-235K-1.48M1.37M5.67M3.61M3.98M
Cash from Investing
378.78K-180K528K-7K-22K-13K0-225.68M-201.78M-186.74M
Capital Expenditures
-2.57K-8K-21K-7K-22K-13K0-218K-73K-108K
CapEx % of Revenue
-0%-------0.04%0.04%
Acquisitions
-572.59K0500K0000000
Investments
----------
Other Investing
953.94K-172K49K0000000
Cash from Financing
23.94M17.83M14.48M53.72M-128K14.09M180.02M213.03M137.16M132.72M
Debt Issued (Net)
00-2K-17K-8K0049.89M00
Equity Issued (Net)
25.01M16.3M14.48M53.72M014.11M137.86M148.96M137.96M134.73M
Dividends Paid
0000000000
Share Repurchases
00000000-100.15M-100.15M
Other Financing
-838K1.52M017K-120K-16K42.16M14.18M-803K-2.01M
Net Change in Cash
14.37M▲ 0%
5.96M▼ 58.5%
-2.37M▼ 139.7%
28.49M▲ 1304.2%
-27.92M▼ 198.0%
-6.7M▲ 76.0%
155.08M▲ 2413.9%
-81.75M▼ 152.7%
-17.82M▲ 78.2%
51.7M▲ 0%
Free Cash Flow
-9.95M▲ 0%
-11.69M▼ 17.5%
-17.4M▼ 48.8%
-25.23M▼ 45.0%
-27.79M▼ 10.2%
-20.79M▲ 25.2%
-24.94M▼ 19.9%
-69.31M▼ 177.9%
46.73M▲ 167.4%
105.6M▲ 0%
FCF Margin %
0.64%-------24.54%37.05%
FCF Growth %
26.48%-17.47%-48.8%-45.04%-10.15%25.18%-19.94%-177.92%167.41%217.95%
FCF per Share
-16.63-8.36-7.64-6.04-5.23-2.48-1.51-1.730.861.99
FCF Conversion (FCF/Net Income)
0.64x0.88x0.56x1.02x0.90x0.86x0.64x0.39x2.24x1.10x
Interest Paid
0000000000
Taxes Paid
800000000000

SLNO Key Ratios

Soleno Therapeutics, Inc. (SLNO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-104.55%-46.83%-135.69%-81.46%-97.6%-171.05%-46.45%-87.35%6.01%22.86%
Return on Invested Capital (ROIC)
-179.97%-128.07%-1898.28%-----142%3.78%21.63%
Gross Margin
100.1%-------98.58%98.63%
Net Margin
1.01%-------10.97%33.7%
Debt / Equity
--0.02x0.00x0.03x0.01x0.00x0.22x0.01x0.01x
Interest Coverage
--221.52x------760.26x4.81x18.59x
FCF Conversion
0.64x0.88x0.56x1.02x0.90x0.86x0.64x0.39x2.24x1.10x
Revenue Growth
-107145.41%100%--------
Related:SLNO Dividend History·SLNO Revenue History·SLNO Price History·SLNO P/E History·SLNO Financial Ratios·SLNO Institutional Holders

SLNO SEC Filings & Documents

Soleno Therapeutics, Inc. (SLNO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 18, 2026·SEC

Material company update

Apr 7, 2026·SEC

Material company update

Apr 6, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 25, 2026·SEC

FY 2025

Feb 28, 2025·SEC

FY 2024

Mar 7, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 6, 2025·SEC

SLNO Frequently Asked Questions

Soleno Therapeutics, Inc. (SLNO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Soleno Therapeutics, Inc. (SLNO) reported $285.0M in revenue for fiscal year 2025.

Soleno Therapeutics, Inc. (SLNO) grew revenue by 0.0% over the past year. Growth has been modest.

Yes, Soleno Therapeutics, Inc. (SLNO) is profitable, generating $96.0M in net income for fiscal year 2025 (11.0% net margin).

Dividend & Returns

Soleno Therapeutics, Inc. (SLNO) has a return on equity (ROE) of 6.0%. This is below average, suggesting room for improvement.

Soleno Therapeutics, Inc. (SLNO) generated $105.6M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in SLNO back in 2012?

Total return calculator · dividends reinvested · 14+ years of data

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How much would $100/month in SLNO be worth today?

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