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Soleno Therapeutics, Inc. (SLNO) Total Return Calculator with Dividends Reinvested

Soleno Therapeutics, Inc.

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The total return for Soleno Therapeutics, Inc. (SLNO) stock is -28.18% over the past 12 months. So far it's up 12.23% this year. The 5-year total return is -33.41%, meaning $10,000 invested in SLNO stock 5 years ago would be worth $6,659 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in SLNO 1 year ago, it would be worth $7,091 today — you'd have lost $2,909.

With Dividends Reinvested$7,091-29.09%

Price Only (No DRIP)$7,091-29.09%

Period2025-05-07 → 2026-05-06

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in SLNO

1Y$7,182-$2,818 (-28.2%)-28.2% CAGR

3Y$25,210+$15,210 (+152.1%)36.1% CAGR

5Y$6,659-$3,341 (-33.4%)-7.8% CAGR

10Y$1,217-$8,783 (-87.8%)-19.0% CAGR

15Y$364-$9,636 (-96.4%)-19.8% CAGR

20Y$364-$9,636 (-96.4%)-15.3% CAGR

30Y$364-$9,636 (-96.4%)-10.5% CAGR

Soleno Therapeutics, Inc. did not pay dividends during this period. Total return = price return.

Loading SLNO total return...

As of 2026-05-07

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	+12.23%	—	+12.23%	—	$11,223
1Y	-28.18%	-28.18%	-28.18%	—	$7,182
3Y	+152.10%	36.10%	+152.10%	—	$25,210
5Y	-33.41%	-7.81%	-33.41%	—	$6,659
10Y	-87.83%	-18.99%	-87.83%	—	$1,217
15Y	-96.36%	-19.82%	-96.36%	—	$364
20Y	-96.36%	-15.27%	-96.36%	—	$364
30Y	-96.36%	-10.46%	-96.36%	—	$364

Risk & Highlights

Best Year+267.58%2023

Worst Year-79.60%2021

Max Drawdown-66.04%2025-07-09 → 2026-03-27

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	-17.17%	-17.17%	—	+0.41%	-17.6pp
2025	+1.29%	+1.29%	—	+16.64%	-15.3pp
2024	+18.45%	+18.45%	—	+24.00%	-5.6pp
2023	+267.58%	+267.58%	—	+24.81%	+242.8pp
2022	-70.09%	-70.09%	—	-19.95%	-50.1pp

SLNO underperformed the S&P 500 by 59.50pp over the past year (-28.18% vs +31.32%).

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SLNO Peers' Total Return

Accurate peer set · 10 comparable names

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
SLNOSoleno Therapeutics, Inc.	$2.8B	+1.3%	+12.2%	-28.2%	—	+152.1%	-33.4%	-87.8%
RAREUltragenyx Pharmaceutical Inc.	$2.5B	+13.4%	+9.9%	-26.0%	—	-44.9%	-77.6%	-58.9%
ACADACADIA Pharmaceuticals Inc.	$3.7B	-3.8%	-17.9%	+47.7%	—	-0.3%	+2.5%	-22.3%
RYTMRhythm Pharmaceuticals, Inc.	$6.6B	+11.1%	-8.0%	+54.1%	—	+479.5%	+349.3%	+222.0%
MDGLMadrigal Pharmaceuticals, Inc.	$12.4B	+1.1%	-9.1%	+82.9%	—	+74.7%	+326.0%	+3755.2%
PTCTPTC Therapeutics, Inc.	$5.5B	-3.3%	-13.2%	+84.1%	—	+19.9%	+65.2%	+839.5%
ANABAnaptysBio, Inc.	$2.9B	+61.9%	+124.8%	+402.3%	—	+377.4%	+294.8%	+494.5%
FOLDAmicus Therapeutics, Inc.	$4.5B	+0.3%	+1.5%	+134.1%	—	+19.0%	+50.9%	+125.0%
KRYSKrystal Biotech, Inc.	$8.5B	+10.3%	+17.0%	+107.1%	—	+229.6%	+310.3%	+2615.2%
IMVTImmunovant, Inc.	$5.8B	+15.2%	+10.7%	+107.2%	—	+48.4%	+73.9%	+188.1%
LGNDLigand Pharmaceuticals Incorporated	$4.6B	+14.2%	+22.3%	+125.1%	—	+200.3%	+83.9%	+95.1%

Compare:SLNO vs RARE SLNO vs ACAD SLNO vs RYTM SLNO vs RARE vs ACAD

About SLNO Dividend Returns

Soleno Therapeutics, Inc. (SLNO) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of SLNO over the past year?

Soleno Therapeutics, Inc. (SLNO) delivered a return of -28.18% over the past year. Since SLNO does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in SLNO be worth today?

A $10,000 investment in Soleno Therapeutics, Inc. one year ago would be worth $7,182 today, representing a loss of $2,818.

Q3Does SLNO pay dividends?

Soleno Therapeutics, Inc. (SLNO) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For SLNO, the total return equals the price-only return.

Q4Did SLNO beat the S&P 500?

No, Soleno Therapeutics, Inc. (SLNO) underperformed the S&P 500 by 59.50 percentage points over the past year. SLNO delivered a total return of -28.18%, compared to the S&P 500's 31.32%. This means a passive S&P 500 index fund outperformed SLNO by 59.50pp during this period.

Q5What is SLNO's worst drawdown?

Soleno Therapeutics, Inc. (SLNO) experienced a maximum drawdown of -66.04% over the past year, declining from its peak on 2025-07-09 to its trough on 2026-03-27. The stock has not yet fully recovered to its prior peak. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is SLNO's long-term total return over 10, 20, or 30 years?

Here are Soleno Therapeutics, Inc. (SLNO)'s long-term returns with dividends reinvested. Over 10 years, the total return is -87.8% (-19.0% CAGR) — $10,000 would have grown to $1,217. Over 20 years: -96.4% total return (-15.3% CAGR) — $10,000 → $364. Over 30 years: -96.4% total return (-10.5% CAGR) — $10,000 → $364. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was SLNO's best and worst year?

Soleno Therapeutics, Inc.'s best calendar year was 2023 with a total return of 267.6%. Its worst year was 2021 with a total return of -79.6%. This range shows the volatility investors should expect — the difference between the best and worst year is 347.2 percentage points.