Spero Therapeutics, Inc. (SPRO) — Estimates & Forecasts
Proprietary EPS, revenue & margin forecasts — FY+1 to FY+4
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Proprietary EPS, revenue & margin forecasts — FY+1 to FY+4
| Metric | 2022 | 2023 | 2024 | 2026E | 2027E | 2028E |
|---|---|---|---|---|---|---|
| Net Income | $-46M | $23M | $-69M | $16M | $31M | $36M |
| EPS (Diluted) | $-1.23 | $0.43 | $-1.27 | $0.28 | $0.54 | $0.61 |
| YoY Growth | — | — | -400.6% | — | +97.5% | +14.4% |
| Net Margin | -95.5% | 22.0% | -142.9% | 34.3% | 50.0% | 50.0% |
| Metric | 2024A | 2025E | 2026E | 2027E | 2028E |
|---|---|---|---|---|---|
| Revenue | $48M | $37M | $46M | $62M | $71M |
| Net Income | $-69M | $-7M | $16M | $31M | $36M |
| EPS (Diluted) | $-1.27 | $-0.12 | $0.28 | $0.54 | $0.61 |
| Free Cash Flow | $-23M | $-4M | $7M | $9M | $11M |
Treat point estimates cautiously; use wider scenario ranges and position sizing discipline.
Spero Therapeutics, Inc.'s projected EPS for the next fiscal year is $-0.12. This estimate blends our quantitative model with Wall Street analyst consensus and carries a confidence score of 29/100. The model factors in revenue trajectory, margin path, and share buyback trends to arrive at this figure.
Our scenario-based model produces three price targets for Spero Therapeutics, Inc.: Bear case $N/A, Base case $N/A, and Bull case $N/A. These targets are derived by applying the median historical P/E ratio to forward EPS estimates under each growth scenario. They are not buy/sell recommendations.
Spero Therapeutics, Inc.'s projected revenue growth for the next fiscal year is 4.4%, reaching approximately $0.0B in total revenue. Growth estimates are probability-weighted and blend analyst consensus with our CAGR extrapolation model. Outer years (FY+3, FY+4) fade toward industry median growth rates.
Accuracy depends on several measurable factors. Our model confidence score of 29/100 is computed from revenue predictability (25% weight), margin stability (20%), historical earnings beat rate (20%), data depth (15%), analyst coverage (10%), and model-consensus agreement (10%). Currently expanding margins support higher forecast reliability. No forecast model is perfect — always cross-reference with your own analysis.
Spero Therapeutics, Inc.'s forward operating margin is estimated at -42.2% for the next fiscal year. The margin trend is currently "expanding". Our model tracks margin mean-reversion patterns and adjusts for sector-specific cost dynamics. Operating leverage is a key driver of EPS growth beyond top-line revenue expansion.
The v2 model uses a multi-step process: (1) Revenue is projected via blended CAGR with probability weighting, (2) Operating and net margins follow a mean-reversion path calibrated to sector norms, (3) EPS is derived from net income divided by projected diluted shares (accounting for buyback trends), (4) For FY+1 and FY+2, estimates are blended with analyst consensus based on coverage depth, (5) Price targets apply median historical P/E to forward EPS under bear/base/bull growth scenarios. All inputs are from public filings and third-party data providers.
The bear case ($N/A) assumes P25 revenue growth, worst-case margins, and multiple compression. Key risks include: unexpected margin contraction, revenue deceleration below model floor, regulatory headwinds, macro deterioration, or competitive disruption. A confidence score below 60 suggests higher estimate volatility. Always size positions according to the full scenario range, not just the base case.
Our model is below Wall Street consensus with a 118.5% gap. For FY+1, analyst estimates blend with our model at 15% analyst weight. By FY+3 and FY+4, estimates are purely model-driven as analyst coverage thins out at longer horizons.